CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-012479
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Membrane protein MLC1 
Protein Synonyms/Alias
  
Gene Name
 MLC1 
Gene Synonyms/Alias
 KIAA0027; WKL1 
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
360EVARSPLKEFDKEKAubiquitination[1, 2]
Reference
 [1] A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles.
 Wagner SA, Beli P, Weinert BT, Nielsen ML, Cox J, Mann M, Choudhary C.
 Mol Cell Proteomics. 2011 Oct;10(10):M111.013284. [PMID: 21890473]
 [2] hCKSAAP_UbSite: improved prediction of human ubiquitination sites by exploiting amino acid pattern and properties.
 Chen Z, Zhou Y, Song J, Zhang Z.
 Biochim Biophys Acta. 2013 Aug;1834(8):1461-7. [PMID: 23603789] 
Functional Description
 Regulates the response of astrocytes to hypo-osmosis by promoting calcium influx. 
Sequence Annotation
  
Keyword
 Cell membrane; Complete proteome; Cytoplasm; Direct protein sequencing; Disease mutation; Endoplasmic reticulum; Ion channel; Ion transport; Membrane; Polymorphism; Reference proteome; Transmembrane; Transmembrane helix; Transport. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 377 AA 
Protein Sequence
MTQEPFREEL AYDRMPTLER GRQDPASYAP DAKPSDLQLS KRLPPCFSHK TWVFSVLMGS 60
CLLVTSGFSL YLGNVFPAEM DYLRCAAGSC IPSAIVSFTV SRRNANVIPN FQILFVSTFA 120
VTTTCLIWFG CKLVLNPSAI NINFNLILLL LLELLMAATV IIAARSSEED CKKKKGSMSD 180
SANILDEVPF PARVLKSYSV VEVIAGISAV LGGIIALNVD DSVSGPHLSV TFFWILVACF 240
PSAIASHVAA ECPSKCLVEV LIAISSLTSP LLFTASGYLS FSIMRIVEMF KDYPPAIKPS 300
YDVLLLLLLL VLLLQAGLNT GTAIQCVRFK VSARLQGASW DTQNGPQERL AGEVARSPLK 360
EFDKEKAWRA VVVQMAQ 377 
Gene Ontology
 GO:0016324; C:apical plasma membrane; IEA:Compara.
 GO:0016323; C:basolateral plasma membrane; IDA:UniProtKB.
 GO:0005901; C:caveola; ISS:UniProtKB.
 GO:0005911; C:cell-cell junction; IEA:Compara.
 GO:0031410; C:cytoplasmic vesicle; IDA:UniProtKB.
 GO:0005769; C:early endosome; ISS:UniProtKB.
 GO:0005783; C:endoplasmic reticulum; IDA:UniProtKB.
 GO:0016021; C:integral to membrane; IDA:UniProtKB.
 GO:0005764; C:lysosome; ISS:UniProtKB.
 GO:0048471; C:perinuclear region of cytoplasm; IDA:UniProtKB.
 GO:0055037; C:recycling endosome; ISS:UniProtKB.
 GO:0032403; F:protein complex binding; IDA:UniProtKB.
 GO:0008565; F:protein transporter activity; ISS:UniProtKB.
 GO:0072584; P:caveolin-mediated endocytosis; ISS:UniProtKB.
 GO:0071397; P:cellular response to cholesterol; ISS:UniProtKB.
 GO:0006811; P:ion transport; IEA:UniProtKB-KW.
 GO:0032388; P:positive regulation of intracellular transport; IDA:UniProtKB.
 GO:0051259; P:protein oligomerization; IDA:UniProtKB.
 GO:0047484; P:regulation of response to osmotic stress; IMP:UniProtKB. 
Interpro
  
Pfam
  
SMART
  
PROSITE
  
PRINTS