CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-021261
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 B-cell lymphoma/leukemia 11A 
Protein Synonyms/Alias
 BCL-11A; B-cell CLL/lymphoma 11A; COUP-TF-interacting protein 1; Ecotropic viral integration site 9 protein homolog; EVI-9; Zinc finger protein 856 
Gene Name
 BCL11A 
Gene Synonyms/Alias
 CTIP1; EVI9; KIAA1809; ZNF856 
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
123SSRGICPKQEHIADKubiquitination[1]
130KQEHIADKLLHWRGLubiquitination[2]
Reference
 [1] Integrated proteomic analysis of post-translational modifications by serial enrichment.
 Mertins P, Qiao JW, Patel J, Udeshi ND, Clauser KR, Mani DR, Burgess MW, Gillette MA, Jaffe JD, Carr SA.
 Nat Methods. 2013 Jul;10(7):634-7. [PMID: 23749302]
 [2] A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles.
 Wagner SA, Beli P, Weinert BT, Nielsen ML, Cox J, Mann M, Choudhary C.
 Mol Cell Proteomics. 2011 Oct;10(10):M111.013284. [PMID: 21890473] 
Functional Description
 Functions as a myeloid and B-cell proto-oncogene. May play important roles in leukemogenesis and hematopoiesis. An essential factor in lymphopoiesis, is required for B-cell formation in fetal liver. May function as a modulator of the transcriptional repression activity of ARP1 (By similarity). 
Sequence Annotation
 ZN_FING 170 193 C2H2-type 1.
 ZN_FING 377 399 C2H2-type 2.
 ZN_FING 405 429 C2H2-type 3.
 ZN_FING 742 764 C2H2-type 4.
 ZN_FING 770 792 C2H2-type 5.
 ZN_FING 800 823 C2H2-type 6.
 REGION 1 210 Required for nuclear body formation and
 MOD_RES 205 205 Phosphoserine.
 MOD_RES 332 332 Phosphoserine.
 MOD_RES 608 608 Phosphoserine.
 MOD_RES 625 625 Phosphoserine.
 MOD_RES 630 630 Phosphoserine.
 MOD_RES 701 701 Phosphothreonine.
 CROSSLNK 634 634 Glycyl lysine isopeptide (Lys-Gly)  
Keyword
 Alternative splicing; Chromosomal rearrangement; Complete proteome; Cytoplasm; Isopeptide bond; Metal-binding; Nucleus; Phosphoprotein; Polymorphism; Reference proteome; Repeat; Repressor; Transcription; Transcription regulation; Ubl conjugation; Zinc; Zinc-finger. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 835 AA 
Protein Sequence
MSRRKQGKPQ HLSKREFSPE PLEAILTDDE PDHGPLGAPE GDHDLLTCGQ CQMNFPLGDI 60
LIFIEHKRKQ CNGSLCLEKA VDKPPSPSPI EMKKASNPVE VGIQVTPEDD DCLSTSSRGI 120
CPKQEHIADK LLHWRGLSSP RSAHGALIPT PGMSAEYAPQ GICKDEPSSY TCTTCKQPFT 180
SAWFLLQHAQ NTHGLRIYLE SEHGSPLTPR VGIPSGLGAE CPSQPPLHGI HIADNNPFNL 240
LRIPGSVSRE ASGLAEGRFP PTPPLFSPPP RHHLDPHRIE RLGAEEMALA THHPSAFDRV 300
LRLNPMAMEP PAMDFSRRLR ELAGNTSSPP LSPGRPSPMQ RLLQPFQPGS KPPFLATPPL 360
PPLQSAPPPS QPPVKSKSCE FCGKTFKFQS NLVVHRRSHT GEKPYKCNLC DHACTQASKL 420
KRHMKTHMHK SSPMTVKSDD GLSTASSPEP GTSDLVGSAS SALKSVVAKF KSENDPNLIP 480
ENGDEEEEED DEEEEEEEEE EEEELTESER VDYGFGLSLE AARHHENSSR GAVVGVGDES 540
RALPDVMQGM VLSSMQHFSE AFHQVLGEKH KRGHLAEAEG HRDTCDEDSV AGESDRIDDG 600
TVNGRGCSPG ESASGGLSKK LLLGSPSSLS PFSKRIKLEK EFDLPPAAMP NTENVYSQWL 660
AGYAASRQLK DPFLSFGDSR QSPFASSSEH SSENGSLRFS TPPGELDGGI SGRSGTGSGG 720
STPHISGPGP GRPSSKEGRR SDTCEYCGKV FKNCSNLTVH RRSHTGERPY KCELCNYACA 780
QSSKLTRHMK THGQVGKDVY KCEICKMPFS VYSTLEKHMK KWHSDRVLNN DIKTE 835 
Gene Ontology
 GO:0005737; C:cytoplasm; ISS:BHF-UCL.
 GO:0005634; C:nucleus; IDA:BHF-UCL.
 GO:0003676; F:nucleic acid binding; IEA:InterPro.
 GO:0042803; F:protein homodimerization activity; TAS:BHF-UCL.
 GO:0003714; F:transcription corepressor activity; IEA:Compara.
 GO:0008270; F:zinc ion binding; IEA:InterPro.
 GO:0030183; P:B cell differentiation; IEA:Compara.
 GO:0030097; P:hemopoiesis; NAS:UniProtKB.
 GO:0030517; P:negative regulation of axon extension; ISS:BHF-UCL.
 GO:0048671; P:negative regulation of collateral sprouting; IMP:BHF-UCL.
 GO:2000171; P:negative regulation of dendrite development; IMP:BHF-UCL.
 GO:0010629; P:negative regulation of gene expression; IEA:Compara.
 GO:0032463; P:negative regulation of protein homooligomerization; IC:BHF-UCL.
 GO:0048672; P:positive regulation of collateral sprouting; IMP:BHF-UCL.
 GO:0010976; P:positive regulation of neuron projection development; IDA:BHF-UCL.
 GO:0045944; P:positive regulation of transcription from RNA polymerase II promoter; ISS:BHF-UCL.
 GO:0016925; P:protein sumoylation; ISS:UniProtKB.
 GO:0050773; P:regulation of dendrite development; IMP:BHF-UCL.
 GO:0006355; P:regulation of transcription, DNA-dependent; IEA:UniProtKB-KW.
 GO:0030217; P:T cell differentiation; IEA:Compara.
 GO:0006351; P:transcription, DNA-dependent; IEA:UniProtKB-KW. 
Interpro
 IPR007087; Znf_C2H2.
 IPR015880; Znf_C2H2-like.
 IPR013087; Znf_C2H2/integrase_DNA-bd. 
Pfam
 PF00096; zf-C2H2 
SMART
 SM00355; ZnF_C2H2 
PROSITE
 PS00028; ZINC_FINGER_C2H2_1
 PS50157; ZINC_FINGER_C2H2_2 
PRINTS