CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-035125
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Protein Med1 
Protein Synonyms/Alias
 Similar to peroxisome proliferator-activated receptor binding protein (Predicted), isoform CRA_b 
Gene Name
 Med1 
Gene Synonyms/Alias
 RGD1559552_predicted; rCG_35233 
Created Date
 July 27, 2013 
Organism
 Rattus norvegicus (Rat) 
NCBI Taxa ID
 10116 
Lysine Modification
Position
Peptide
Type
References
684SSRVPPDKPKHQTEDacetylation[1]
950LTTGELGKEKTQKRVacetylation[1]
1060KGTVMVGKPSSHSQYacetylation[1]
1099SSASTSGKMKSSKSEacetylation[1]
1174LMNPSISKPNISPSHacetylation[1]
1196DKLASPMKPVPGTPPacetylation[1]
1285GKSPSRNKKPSLTAVacetylation[1]
1295SLTAVIDKLKHGVVTacetylation[1]
1398KAKVTLQKPGDSGGEacetylation[1]
1515KKKSHSIKPENWSKSacetylation[1]
Reference
 [1] Proteomic analysis of lysine acetylation sites in rat tissues reveals organ specificity and subcellular patterns.
 Lundby A, Lage K, Weinert BT, Bekker-Jensen DB, Secher A, Skovgaard T, Kelstrup CD, Dmytriyev A, Choudhary C, Lundby C, Olsen JV.
 Cell Rep. 2012 Aug 30;2(2):419-31. [PMID: 22902405] 
Functional Description
  
Sequence Annotation
  
Keyword
 Complete proteome; Receptor; Reference proteome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 1567 AA 
Protein Sequence
MSSLLDRLHA KFNQSRPWSE TIKLVRQVME KRVVMSSGGH QHLVSCLETL QKALKVTSLP 60
AMTDRLESIA RQNGLGSHLS ASGTECYITS DMFYVEVQLD PAGQLCDVKV AHHGENPVSC 120
PELVQQLREK NFDEFSKHLK GLVNLYNLPG DNKLKTKMYL ALQSLEQDLS KMAIMYWKAT 180
NATPLDKILH GSVGYLTPRS GGHLMNMKYY ASPSDLLHDT TASPITLHEK NVPRSLGMNA 240
SVTIEGTSAM YKLPIAPLIM GSHPADNKWT PSFSAVTSAN SVDLPACFFL KFPQPIPVSK 300
AFVQKLQNCT GIPLFETPPT YLPLYELITQ FELSKDPDPL PLNHNMRFYA ALPGQQHCYF 360
LNKDAPLPDG QSLQGTLVSK ITFQHPGRVP LILNMIRHQV AYNTLIGSCV KRTILKEDSP 420
GLLQFEVCPL SESRFSVSFQ HPVNDSLVCV VMDVQDSTHV SCKLYKGLSD ALICTDDFIA 480
KVVQRCMSIP VTMRAIRRKA ETIQADTPAL SLIAETVEDM VKKNLPPASS PGYGMTTGSN 540
PMSGTTTPTN TFPGGPITTL FNMSMSIKDR HESVGHGEDF SKVSQNPILT SLLQITGNGG 600
STIGSSPTPP HHTPPPVSSM AGNTKNHPML MNLLKDNPAQ DFSTLYGSSP LERQNSSSGS 660
PRMEMCSGSN KTKKNKSSRV PPDKPKHQTE DDFQRELFSM DVDSQNPMFD VSMTADALDT 720
PHITPAPSQC STPPTTYPQP VSHPQPSIQR MGRLSSSDSI GPDVTDILSD IAEEASKLPS 780
TSDDCPPIGT PVRDSSSSGH SQSALFDSDV FQTNNNENPY TDPADLIADA AGSPSSDSPT 840
NHFFPDGVDF NPDLLNSQSQ SGFGEEYFDE SSQSGDNDDF KGFASQALNT LGMPMLGGDN 900
GESKLKGSSQ ADTVDFSILS VAGKALGAAD LLEHHSGSQS PLLTTGELGK EKTQKRVKEG 960
NGMGASSGSG PGSDSKPGKR SRTPSNDGKS KDKPPKRKKA DTEGKSPSHS SNRPFTPPTS 1020
TGGSKSPGSS GRCQTPPGVA TPPIPKITIQ IPKGTVMVGK PSSHSQYSSS GSVSSSGSKS 1080
HHSHSSSSSS LSSASTSGKM KSSKSEGSSS AKLSGSMYSS QGSSGSSQSK NSSQTGGKPG 1140
SSPITKHGLS SGSSSTKMKP QGKPSSLMNP SISKPNISPS HSRPPGGSDK LASPMKPVPG 1200
TPPSSKAKSP ISSGSGSSHV SGTSSSSGMK SSSGSGSSGS LSQKTPPASN SCTPSSSSFS 1260
SSGSSMSSSQ NQHGSSKGKS PSRNKKPSLT AVIDKLKHGV VTSGPGGEDP IDSQMGASTN 1320
SSNHPMSSKH NMSGGEFQSK REKSDKDKSK VSTSGGSVDS SKKTSESKNV GSTGVAKIII 1380
SKHDGGSPSI KAKVTLQKPG DSGGEGLRPQ IASSKNYGSP LISGSTPKHE RGSPSHSKSP 1440
AYTPQNVDSE SESGSSIAER SYQNSPSSDD GVRPLPEYST EKHKKHKKEK KKVKDKDRDR 1500
DRDKDRDKKK SHSIKPENWS KSPISSDQTS SMTNNPILSA DRPSRLSPDF MIGEEDDDLM 1560
DVALIGN 1567 
Gene Ontology
 GO:0000785; C:chromatin; IDA:RGD.
 GO:0016592; C:mediator complex; IEA:Compara.
 GO:0005730; C:nucleolus; IEA:Compara.
 GO:0005634; C:nucleus; IDA:RGD.
 GO:0032993; C:protein-DNA complex; IDA:RGD.
 GO:0031490; F:chromatin DNA binding; IDA:RGD.
 GO:0001047; F:core promoter binding; IEA:Compara.
 GO:0032403; F:protein complex binding; IDA:RGD.
 GO:0004872; F:receptor activity; IEA:Compara.
 GO:0000978; F:RNA polymerase II core promoter proximal region sequence-specific DNA binding; IDA:RGD.
 GO:0001104; F:RNA polymerase II transcription cofactor activity; IDA:RGD.
 GO:0000981; F:sequence-specific DNA binding RNA polymerase II transcription factor activity; IEA:Compara.
 GO:0046966; F:thyroid hormone receptor binding; IDA:RGD.
 GO:0030375; F:thyroid hormone receptor coactivator activity; IEA:Compara.
 GO:0042809; F:vitamin D receptor binding; IDA:RGD.
 GO:0006702; P:androgen biosynthetic process; IEA:Compara.
 GO:0030521; P:androgen receptor signaling pathway; IEA:Compara.
 GO:0001525; P:angiogenesis; IEA:Compara.
 GO:0007420; P:brain development; IEP:RGD.
 GO:0000902; P:cell morphogenesis; IEA:Compara.
 GO:0071364; P:cellular response to epidermal growth factor stimulus; IEA:Compara.
 GO:0035729; P:cellular response to hepatocyte growth factor stimulus; IEA:Compara.
 GO:0071383; P:cellular response to steroid hormone stimulus; IEA:Compara.
 GO:0097067; P:cellular response to thyroid hormone stimulus; IDA:RGD.
 GO:0006260; P:DNA replication; IEA:Compara.
 GO:0035050; P:embryonic heart tube development; IEA:Compara.
 GO:0035162; P:embryonic hemopoiesis; IEA:Compara.
 GO:0035116; P:embryonic hindlimb morphogenesis; IEA:Compara.
 GO:0001892; P:embryonic placenta development; IEA:Compara.
 GO:0048822; P:enucleate erythrocyte development; IEA:Compara.
 GO:0060750; P:epithelial cell proliferation involved in mammary gland duct elongation; IEA:Compara.
 GO:0070371; P:ERK1 and ERK2 cascade; IEA:Compara.
 GO:0045444; P:fat cell differentiation; IEA:Compara.
 GO:0030216; P:keratinocyte differentiation; IEA:Compara.
 GO:0007595; P:lactation; IEA:Compara.
 GO:0002088; P:lens development in camera-type eye; IEA:Compara.
 GO:0001889; P:liver development; IEA:Compara.
 GO:0060745; P:mammary gland branching involved in pregnancy; IEA:Compara.
 GO:0060744; P:mammary gland branching involved in thelarche; IEA:Compara.
 GO:0035855; P:megakaryocyte development; IEA:Compara.
 GO:0030224; P:monocyte differentiation; IEA:Compara.
 GO:0042789; P:mRNA transcription from RNA polymerase II promoter; IEA:Compara.
 GO:0043066; P:negative regulation of apoptotic process; IEA:Compara.
 GO:0010839; P:negative regulation of keratinocyte proliferation; IEA:Compara.
 GO:0045665; P:negative regulation of neuron differentiation; IEA:Compara.
 GO:0000122; P:negative regulation of transcription from RNA polymerase II promoter; IEA:Compara.
 GO:0031100; P:organ regeneration; IEA:Compara.
 GO:0035357; P:peroxisome proliferator activated receptor signaling pathway; IEA:Compara.
 GO:0070318; P:positive regulation of G0 to G1 transition; IEA:Compara.
 GO:2000347; P:positive regulation of hepatocyte proliferation; IEA:Compara.
 GO:0060335; P:positive regulation of interferon-gamma-mediated signaling pathway; IEA:Compara.
 GO:0033148; P:positive regulation of intracellular estrogen receptor signaling pathway; IEA:Compara.
 GO:0045618; P:positive regulation of keratinocyte differentiation; IEA:Compara.
 GO:0033601; P:positive regulation of mammary gland epithelial cell proliferation; IEA:Compara.
 GO:0033160; P:positive regulation of protein import into nucleus, translocation; IEA:Compara.
 GO:0045944; P:positive regulation of transcription from RNA polymerase II promoter; IDA:RGD.
 GO:0006356; P:regulation of transcription from RNA polymerase I promoter; IEA:Compara.
 GO:0070562; P:regulation of vitamin D receptor signaling pathway; IEA:Compara.
 GO:0003406; P:retinal pigment epithelium development; IEA:Compara.
 GO:0006590; P:thyroid hormone generation; IEA:Compara.
 GO:0002154; P:thyroid hormone mediated signaling pathway; IEA:Compara.
 GO:0006367; P:transcription initiation from RNA polymerase II promoter; IEA:Compara.
 GO:0003222; P:ventricular trabecula myocardium morphogenesis; IEA:Compara. 
Interpro
 IPR019680; Mediator_Med1_met/fun. 
Pfam
 PF10744; Med1 
SMART
  
PROSITE
  
PRINTS