CPLM 1.0 - Compendium of Protein Lysine Modification
Tag
Content
CPLM ID
CPLM-024262
UniProt Accession
Y5435_MYCS2
;
A0R3D6
;
I7G7N1
Genbank Protein ID
CP000480
;
CP001663
Genbank Nucleotide ID
ABK72855.1
;
AFP41727.1
Protein Name
Putative ligase MSMEG_5435/MSMEI_5285
Protein Synonyms/Alias
Gene Name
MSMEG_5435, MSMEI_5285
Gene Synonyms/Alias
Created Date
July 27, 2013
Organism
Mycobacterium smegmatis (strain ATCC 700084 / mc(2)155)
NCBI Taxa ID
246196
Lysine Modification
Position
Peptide
Type
References
528
LGPGSIP
K
TPSGKLR
pupylation
[1]
Reference
[1] Expansion of the mycobacterial "PUPylome".
Watrous J, Burns K, Liu WT, Patel A, Hook V, Bafna V, Barry CE 3rd, Bark S, Dorrestein PC.
Mol Biosyst. 2010 Feb;6(2):376-85. [
PMID: 20094657
]
Functional Description
Sequence Annotation
CROSSLNK 528 528 Isoglutamyl lysine isopeptide (Lys-Gln)
Keyword
Complete proteome; Isopeptide bond; Ligase; Reference proteome; Ubl conjugation.
Sequence Source
UniProt (SWISSPROT/TrEMBL); GenBank; EMBL
Protein Length
545 AA
Protein Sequence
MSRFTEKMYR NARTVTTGMV TGEPHEPVRH TWGEVHERAR RIAGGLAAAG IGHGDAVGVL 60
AGFPVEIAPT AQGVWMRGAS LTMLHQPTPR TDLAVWAEDT MNVIGMIELK AVIISEPFLV 120
ATPVLEEKGI LVLKVADLLA ADPIDPVETG EDDLALMQLT SGSTGSPKAV QITHRNIHSN 180
AEAMFVGAKY DVEKDVMVSW LPCFHDMGMV GFLTIPMYFG AELVKVTPMD FLRDTLLWAK 240
LIDKYKGTMT AAPNFAYALL AKRLRRQAKP GDFDLSTLRF ALSGAEPVEP ADVEDFLDAG 300
KPFGLRPEAI LPAYGMAETT LAVSFSPCGE GLVVDEVDAD LLAALRRAVP ATKGNTKRLA 360
SLGPLLNDLE ARVVDENGEV MPARGVGVIE LRGEPVTPGY ITMGGFVPAQ DEYGWYDTGD 420
LGYITEEGNI VVCGRVKDVI IMAGRNIYPT DIERAAGRVE GVRPGCAVAV RLDAGHSRET 480
FAVAVESNAW QDPAEVRRIE HQVAHEVVSE VDVRPRNVVV LGPGSIPKTP SGKLRRANSV 540
SLVTQ 545
Gene Ontology
GO:0016874
; F:ligase activity; IEA:UniProtKB-KW.
Interpro
IPR020845
; AMP-binding_CS.
IPR000873
; AMP-dep_Synth/Lig.
Pfam
PF00501
; AMP-binding
SMART
PROSITE
PS00455
; AMP_BINDING
PRINTS