UniProt Accession

 B4DJC7_HUMAN; B4DJC7 

Genbank Protein ID

 AC009948; AK296019 

Genbank Nucleotide ID

 BAG58789.1 

Protein Name

 Interferon-inducible double stranded RNA-dependent protein kinase activator A 

Protein Synonyms/Alias

 cDNA FLJ60590, highly similar to Interferon-inducible double strandedRNA-dependent protein kinase activator A 

Gene Name

 PRKRA 

Gene Synonyms/Alias

  

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
60	ESFMETGKGASKKQA	ubiquitination	[1]
64	ETGKGASKKQAKRNA	ubiquitination	[1]
74	AKRNAAEKFLAKFSN	ubiquitination	[1, 2]

Reference

 [1] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961]
 [2] Methods for quantification of in vivo changes in protein ubiquitination following proteasome and deubiquitinase inhibition.
 Udeshi ND, Mani DR, Eisenhaure T, Mertins P, Jaffe JD, Clauser KR, Hacohen N, Carr SA.
 Mol Cell Proteomics. 2012 May;11(5):148-59. [PMID: 22505724] 

Functional Description

  

Sequence Annotation

  

Keyword

 Complete proteome; Kinase; Reference proteome; Transferase. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 200 AA 

Protein Sequence

Gene Ontology

 GO:0005622; C:intracellular; IEA:Compara.
 GO:0003725; F:double-stranded RNA binding; IEA:InterPro.
 GO:0016301; F:kinase activity; IEA:UniProtKB-KW.
 GO:0006917; P:induction of apoptosis; IEA:Compara.
 GO:0042474; P:middle ear morphogenesis; IEA:Compara.
 GO:0042473; P:outer ear morphogenesis; IEA:Compara.
 GO:0006468; P:protein phosphorylation; IEA:Compara.
 GO:0006950; P:response to stress; IEA:Compara.
 GO:0048705; P:skeletal system morphogenesis; IEA:Compara. 

Interpro

 IPR001159; Ds-RNA-bd.
 IPR014720; dsRNA-bd-like_dom. 

Pfam

 PF00035; dsrm 

SMART

 SM00358; DSRM 

PROSITE

 PS50137; DS_RBD 

PRINTS