UniProt Accession

 ANXA6_RAT; P48037 

Genbank Protein ID

 X86086 

Genbank Nucleotide ID

 CAA60040.1 

Protein Name

 Annexin A6 

Protein Synonyms/Alias

 Annexin VI; Annexin-6; Calcium-binding protein 65/67; CBP 65/67 

Gene Name

 Anxa6 

Gene Synonyms/Alias

 Anx6 

Created Date

 July 27, 2013 

Organism

 Rattus norvegicus (Rat) 

NCBI Taxa ID

 10116 

Lysine Modification

Position	Peptide	Type	References
3	*****MAKIAQGAMY	acetylation	[1]
3	*****MAKIAQGAMY	ubiquitination	[2]
40	MKGFGSDKESILELI	acetylation	[1]
135	HQLVAAYKDAYERDL	ubiquitination	[2]
478	RAINEAYKEDYHKSL	ubiquitination	[2]

Reference

 [1] Proteomic analysis of lysine acetylation sites in rat tissues reveals organ specificity and subcellular patterns.
 Lundby A, Lage K, Weinert BT, Bekker-Jensen DB, Secher A, Skovgaard T, Kelstrup CD, Dmytriyev A, Choudhary C, Lundby C, Olsen JV.
 Cell Rep. 2012 Aug 30;2(2):419-31. [PMID: 22902405]
 [2] Synaptic protein ubiquitination in rat brain revealed by antibody-based ubiquitome analysis.
 Na CH, Jones DR, Yang Y, Wang X, Xu Y, Peng J.
 J Proteome Res. 2012 Sep 7;11(9):4722-32. [PMID: 22871113] 

Functional Description

 May associate with CD21. May regulate the release of Ca(2+) from intracellular stores. 

Sequence Annotation

 REPEAT 29 89 Annexin 1.
 REPEAT 101 161 Annexin 2.
 REPEAT 185 245 Annexin 3.
 REPEAT 260 320 Annexin 4.
 REPEAT 372 432 Annexin 5.
 REPEAT 444 504 Annexin 6.
 REPEAT 533 593 Annexin 7.
 REPEAT 608 668 Annexin 8.
 MOD_RES 2 2 N-acetylalanine (By similarity).
 MOD_RES 30 30 Phosphotyrosine (By similarity).
 MOD_RES 63 63 N6-acetyllysine (By similarity).
 MOD_RES 68 68 N6-acetyllysine (By similarity).
 MOD_RES 75 75 N6-acetyllysine (By similarity).
 MOD_RES 81 81 N6-acetyllysine (By similarity).
 MOD_RES 201 201 Phosphotyrosine (By similarity).
 MOD_RES 306 306 N6-acetyllysine (By similarity).
 MOD_RES 370 370 N6-acetyllysine (By similarity).
 MOD_RES 418 418 N6-acetyllysine (By similarity).
 MOD_RES 483 483 N6-acetyllysine (By similarity).
 MOD_RES 620 620 N6-acetyllysine (By similarity).  

Keyword

 Acetylation; Annexin; Calcium; Calcium/phospholipid-binding; Complete proteome; Cytoplasm; Direct protein sequencing; Phosphoprotein; Reference proteome; Repeat. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 673 AA 

Protein Sequence

Gene Ontology

 GO:0016324; C:apical plasma membrane; IDA:RGD.
 GO:0005737; C:cytoplasm; IDA:RGD.
 GO:0042470; C:melanosome; IEA:UniProtKB-SubCell.
 GO:0043234; C:protein complex; IDA:RGD.
 GO:0005509; F:calcium ion binding; IEA:InterPro.
 GO:0005544; F:calcium-dependent phospholipid binding; IDA:RGD.
 GO:0046903; P:secretion; TAS:RGD. 

Interpro

 IPR001464; Annexin.
 IPR018502; Annexin_repeat.
 IPR018252; Annexin_repeat_CS.
 IPR002393; AnnexinVI. 

Pfam

 PF00191; Annexin 

SMART

 SM00335; ANX 

PROSITE

 PS00223; ANNEXIN 

PRINTS

 PR00196; ANNEXIN.
 PR00202; ANNEXINVI.