UniProt Accession

 EFTS_HUMAN; P43897; B4E391; F5H2T7; Q561V7; Q8TBC2; Q9UQK0 

Genbank Protein ID

 AF110399; AK304621; AK308981; AC025165; CH471054; BC022862; BC093068; L37936 

Genbank Nucleotide ID

 AAD20224.1; BAG65403.1; EAW97075.1; AAH22862.1; AAH93068.1; AAC37577.1 

Protein Name

 Elongation factor Ts, mitochondrial 

Protein Synonyms/Alias

 EF-Ts; EF-TsMt 

Gene Name

 TSFM 

Gene Synonyms/Alias

  

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
161	DQPSAYSKGFLNSSE	ubiquitination	[1, 2]
192	QLALAIGKLGENMIL	ubiquitination	[3]
200	LGENMILKRAAWVKV	ubiquitination	[2]

Reference

 [1] Systematic and quantitative assessment of the ubiquitin-modified proteome.
 Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
 Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983]
 [2] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961]
 [3] A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles.
 Wagner SA, Beli P, Weinert BT, Nielsen ML, Cox J, Mann M, Choudhary C.
 Mol Cell Proteomics. 2011 Oct;10(10):M111.013284. [PMID: 21890473] 

Functional Description

 Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome (By similarity). 

Sequence Annotation

 MOD_RES 324 324 Phosphothreonine.  

Keyword

 3D-structure; Alternative splicing; Cardiomyopathy; Complete proteome; Disease mutation; Elongation factor; Mitochondrion; Phosphoprotein; Protein biosynthesis; Reference proteome; Transit peptide. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 325 AA 

Protein Sequence

Gene Ontology

 GO:0005739; C:mitochondrion; IDA:HPA.
 GO:0005634; C:nucleus; IDA:HPA.
 GO:0003746; F:translation elongation factor activity; IEA:HAMAP.
 GO:0032784; P:regulation of DNA-dependent transcription, elongation; TAS:ProtInc.
 GO:0006414; P:translational elongation; TAS:ProtInc. 

Interpro

 IPR001816; Transl_elong_EFTs/EF1B.
 IPR014039; Transl_elong_EFTs/EF1B_dimer.
 IPR018101; Transl_elong_Ts_CS.
 IPR009060; UBA-like.
 IPR000449; UBA/transl_elong_EF1B_N. 

Pfam

 PF00889; EF_TS
 PF00627; UBA 

SMART

  

PROSITE

 PS01126; EF_TS_1
 PS01127; EF_TS_2 

PRINTS