CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-011510
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Sperm-associated antigen 1 
Protein Synonyms/Alias
 HSD-3.8; Infertility-related sperm protein Spag-1 
Gene Name
 SPAG1 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
705ALAHKGLKNYQKSLImethylation[1]
709KGLKNYQKSLIDLNKmethylation[1]
Reference
 [1] Large-scale global identification of protein lysine methylation in vivo.
 Cao XJ, Arnaudo AM, Garcia BA.
 Epigenetics. 2013 May 1;8(5):477-85. [PMID: 23644510] 
Functional Description
 Plays a role in fertilization. Binds GTP and has GTPase activity. 
Sequence Annotation
 REPEAT 209 242 TPR 1.
 REPEAT 244 275 TPR 2.
 REPEAT 276 309 TPR 3.
 REPEAT 445 478 TPR 4.
 REPEAT 487 520 TPR 5.
 REPEAT 522 554 TPR 6.
 REPEAT 623 656 TPR 7.
 REPEAT 657 690 TPR 8.
 REPEAT 692 724 TPR 9.
 NP_BIND 781 788 GTP (Potential).
 MOD_RES 347 347 Phosphoserine.
 MOD_RES 791 791 Phosphoserine.  
Keyword
 Complete proteome; Cytoplasm; Fertilization; GTP-binding; Hydrolase; Nucleotide-binding; Phosphoprotein; Polymorphism; Reference proteome; Repeat; TPR repeat. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 926 AA 
Protein Sequence
MTTKDYPSLW GFGTTKTFKI PIEHLDFKYI EKCSDVKHLE KILCVLRSGE EGYYPELTEF 60
CEKHLQALAP ESRALRKDKP AATAASFTAE EWEKIDGDIK SWVSEIKKEE DKMHFHETET 120
FPAMKDNLPP VRGSNSCLHV GKEKYSKRPT KKKTPRDYAE WDKFDVEKEC LKIDEDYKEK 180
TVIDKSHLSK IETRIDTAGL TEKEKDFLAT REKEKGNEAF NSGDYEEAVM YYTRSISALP 240
TVVAYNNRAQ AEIKLQNWNS AFQDCEKVLE LEPGNVKALL RRATTYKHQN KLREATEDLS 300
KVLDVEPDND LAKKTLSEVE RDLKNSEAAS ETQTKGKRMV IQEIENSEDE EGKSGRKHED 360
GGGDKKPAEP AGAARAAQPC VMGNIQKKLT GKAEGGKRPA RGAPQRGQTP EAGADKRSPR 420
RASAAAAAGG GATGHPGGGQ GAENPAGLKS QGNELFRSGQ FAEAAGKYSA AIALLEPAGS 480
EIADDLSILY SNRAACYLKE GNCSGCIQDC NRALELHPFS MKPLLRRAMA YETLEQYGKA 540
YVDYKTVLQI DCGLQLANDS VNRLSRILME LDGPNWREKL SPIPAVPASV PLQAWHPAKE 600
MISKQAGDSS SHRQQGITDE KTFKALKEEG NQCVNDKNYK DALSKYSECL KINNKECAIY 660
TNRALCYLKL CQFEEAKQDC DQALQLADGN VKAFYRRALA HKGLKNYQKS LIDLNKVILL 720
DPSIIEAKME LEEVTRLLNL KDKTAPFNKE KERRKIEIQE VNEGKEEPGR PAGEVSMGCL 780
ASEKGGKSSR SPEDPEKLPI AKPNNAYEFG QIINALSTRK DKEACAHLLA ITAPKDLPMF 840
LSNKLEGDTF LLLIQSLKNN LIEKDPSLVY QHLLYLSKAE RFKMMLTLIS KGQKELIEQL 900
FEDLSDTPNN HFTLEDIQAL KRQYEL 926 
Gene Ontology
 GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
 GO:0005525; F:GTP binding; IEA:UniProtKB-KW.
 GO:0016787; F:hydrolase activity; IEA:UniProtKB-KW.
 GO:0007338; P:single fertilization; TAS:ProtInc. 
Interpro
 IPR025986; RPAP3-like_C.
 IPR001440; TPR-1.
 IPR013026; TPR-contain_dom.
 IPR011990; TPR-like_helical.
 IPR019734; TPR_repeat. 
Pfam
 PF13877; RPAP3_C
 PF00515; TPR_1 
SMART
 SM00028; TPR 
PROSITE
 PS50005; TPR
 PS50293; TPR_REGION 
PRINTS