| Tag | Content |
|---|
| CPLM ID | CPLM-007993 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | LIM and senescent cell antigen-like-containing domain protein 1 |
Protein Synonyms/Alias | Particularly interesting new Cys-His protein 1; PINCH-1; Renal carcinoma antigen NY-REN-48 |
Gene Name | LIMS1 |
Gene Synonyms/Alias | PINCH; PINCH1 |
Created Date | July 27, 2013 |
Organism | Homo sapiens (Human) |
NCBI Taxa ID | 9606 |
Lysine Modification | Position | Peptide | Type | References |
|---|
| 132 | EKARGLGKYICQKCH | ubiquitination | [1] |
|
Reference | [1] Systems-wide analysis of ubiquitylation dynamics reveals a key role for PAF15 ubiquitylation in DNA-damage bypass. Povlsen LK, Beli P, Wagner SA, Poulsen SL, Sylvestersen KB, Poulsen JW, Nielsen ML, Bekker-Jensen S, Mailand N, Choudhary C. Nat Cell Biol. 2012 Oct;14(10):1089-98. [ PMID: 23000965] |
Functional Description | Adapter protein in a cytoplasmic complex linking beta- integrins to the actin cytoskeleton, bridges the complex to cell surface receptor tyrosine kinases and growth factor receptors. Involved in the regulation of cell survival, cell proliferation and cell differentiation. |
Sequence Annotation | DOMAIN 10 62 LIM zinc-binding 1.
DOMAIN 71 121 LIM zinc-binding 2.
DOMAIN 135 184 LIM zinc-binding 3.
DOMAIN 193 243 LIM zinc-binding 4.
DOMAIN 252 303 LIM zinc-binding 5.
MOD_RES 2 2 N-acetylalanine. |
Keyword | 3D-structure; Acetylation; Alternative splicing; Cell junction; Cell membrane; Complete proteome; Direct protein sequencing; LIM domain; Membrane; Metal-binding; Reference proteome; Repeat; Zinc. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 325 AA |
Protein Sequence | MANALASATC ERCKGGFAPA EKIVNSNGEL YHEQCFVCAQ CFQQFPEGLF YEFEGRKYCE 60
HDFQMLFAPC CHQCGEFIIG RVIKAMNNSW HPECFRCDLC QEVLADIGFV KNAGRHLCRP 120
CHNREKARGL GKYICQKCHA IIDEQPLIFK NDPYHPDHFN CANCGKELTA DARELKGELY 180
CLPCHDKMGV PICGACRRPI EGRVVNAMGK QWHVEHFVCA KCEKPFLGHR HYERKGLAYC 240
ETHYNQLFGD VCFHCNRVIE GDVVSALNKA WCVNCFACST CNTKLTLKNK FVEFDMKPVC 300
KKCYEKFPLE LKKRLKKLAE TLGRK 325 |
Gene Ontology | GO:0005829; C:cytosol; TAS:Reactome. GO:0005925; C:focal adhesion; IDA:UniProtKB. GO:0048471; C:perinuclear region of cytoplasm; IDA:UniProtKB. GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell. GO:0008270; F:zinc ion binding; IDA:UniProtKB. GO:0007569; P:cell aging; TAS:ProtInc. GO:0034329; P:cell junction assembly; TAS:Reactome. GO:0071560; P:cellular response to transforming growth factor beta stimulus; IEP:UniProtKB. GO:0045892; P:negative regulation of transcription, DNA-dependent; IDA:UniProtKB. |
Interpro | |
Pfam | |
SMART | |
PROSITE | |
PRINTS | |