CPLM-024616

Genbank Nucleotide ID

CDGSH iron-sulfur domain-containing protein 3, mitochondrial

Protein Synonyms/Alias

Melanoma nuclear protein 13

Mus musculus (Mouse)

Position	Peptide	Type	References
65	RLELVAGKTYRWCVC	acetylation	[1]
65	RLELVAGKTYRWCVC	succinylation	[1]
96	RTGLSPLKFKAQETR	acetylation	[1, 2, 3, 4, 5]
96	RTGLSPLKFKAQETR	succinylation	[1]
98	GLSPLKFKAQETRTV	acetylation	[3, 4, 5]
124	PYCDGTHKSEQVQKA	acetylation	[1, 2, 3, 4, 5, 6, 7]
124	PYCDGTHKSEQVQKA	succinylation	[1]
130	HKSEQVQKAEVGSPL	acetylation	[2, 4]

[1] SIRT5-Mediated Lysine Desuccinylation Impacts Diverse Metabolic Pathways.
Park J, Chen Y, Tishkoff DX, Peng C, Tan M, Dai L, Xie Z, Zhang Y, Zwaans BM, Skinner ME, Lombard DB, Zhao Y.
Mol Cell. 2013 Jun 27;50(6):919-30. [PMID: 23806337]
[2] Proteomic analysis of lysine acetylation sites in rat tissues reveals organ specificity and subcellular patterns.
Lundby A, Lage K, Weinert BT, Bekker-Jensen DB, Secher A, Skovgaard T, Kelstrup CD, Dmytriyev A, Choudhary C, Lundby C, Olsen JV.
Cell Rep. 2012 Aug 30;2(2):419-31. [PMID: 22902405]
[3] Calorie restriction and SIRT3 trigger global reprogramming of the mitochondrial protein acetylome.
Hebert AS, Dittenhafer-Reed KE, Yu W, Bailey DJ, Selen ES, Boersma MD, Carson JJ, Tonelli M, Balloon AJ, Higbee AJ, Westphall MS, Pagliarini DJ, Prolla TA, Assadi-Porter F, Roy S, Denu JM, Coon JJ.
Mol Cell. 2013 Jan 10;49(1):186-99. [PMID: 23201123]
[4] Label-free quantitative proteomics of the lysine acetylome in mitochondria identifies substrates of SIRT3 in metabolic pathways.
Rardin MJ, Newman JC, Held JM, Cusack MP, Sorensen DJ, Li B, Schilling B, Mooney SD, Kahn CR, Verdin E, Gibson BW.
Proc Natl Acad Sci U S A. 2013 Apr 16;110(16):6601-6. [PMID: 23576753]
[5] Quantification of mitochondrial acetylation dynamics highlights prominent sites of metabolic regulation.
Still AJ, Floyd BJ, Hebert AS, Bingman CA, Carson JJ, Gunderson DR, Dolan BK, Grimsrud PA, Dittenhafer-Reed KE, Stapleton DS, Keller MP, Westphall MS, Denu JM, Attie AD, Coon JJ, Pagliarini DJ.
J Biol Chem. 2013 Jul 17;. [PMID: 23864654]
[6] Quantitative assessment of the impact of the gut microbiota on lysine epsilon-acetylation of host proteins using gnotobiotic mice.
Simon GM, Cheng J, Gordon JI.
Proc Natl Acad Sci U S A. 2012 Jul 10;109(28):11133-8. [PMID: 22733758]
[7] Circadian acetylome reveals regulation of mitochondrial metabolic pathways.
Masri S, Patel VR, Eckel-Mahan KL, Peleg S, Forne I, Ladurner AG, Baldi P, Imhof A, Sassone-Corsi P.
Proc Natl Acad Sci U S A. 2013 Feb 26;110(9):3339-44. [PMID: 23341599]

Functional Description

METAL 70 70 Iron-sulfur 1 (2Fe-2S) (By similarity).
METAL 72 72 Iron-sulfur 1 (2Fe-2S) (By similarity).
METAL 81 81 Iron-sulfur 1 (2Fe-2S) (By similarity).
METAL 85 85 Iron-sulfur 1 (2Fe-2S); via pros nitrogen
METAL 108 108 Iron-sulfur 2 (2Fe-2S) (By similarity).
METAL 110 110 Iron-sulfur 2 (2Fe-2S) (By similarity).
METAL 119 119 Iron-sulfur 2 (2Fe-2S) (By similarity).
METAL 123 123 Iron-sulfur 2 (2Fe-2S); via pros nitrogen
MOD_RES 65 65 N6-acetyllysine (By similarity).

2Fe-2S; Acetylation; Complete proteome; Iron; Iron-sulfur; Metal-binding; Mitochondrion; Reference proteome; Transit peptide.

UniProt (SWISSPROT/TrEMBL); GenBank; EMBL

GO:0005739; C:mitochondrion; IDA:MGI.
GO:0051537; F:2 iron, 2 sulfur cluster binding; IEA:UniProtKB-KW.
GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.

IPR018967; FeS-contain_CDGSH-typ.
IPR006622; FeS-contain_CDGSH-typ_subfam.