CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-037585
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
  
Protein Name
 PHD and RING finger domain-containing protein 1 
Protein Synonyms/Alias
  
Gene Name
 PHRF1 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
149PVDRTLFKCICIRAQubiquitination[1]
160IRAQFGGKILRKIPVubiquitination[1, 2]
171KIPVENTKASEEEEDubiquitination[2]
552SRGEEGFKGCLQPRAubiquitination[1, 2]
664VVPGPPLKPAPRRTDubiquitination[1, 2]
764PLGPSRGKGVGSTFEubiquitination[1, 2]
817SPLFSIKKTKQLRSEubiquitination[1]
865TISINSPKAQTVQAVubiquitination[1, 2]
1575EEVKLAIKPFYQKREubiquitination[3]
Reference
 [1] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961]
 [2] Integrated proteomic analysis of post-translational modifications by serial enrichment.
 Mertins P, Qiao JW, Patel J, Udeshi ND, Clauser KR, Mani DR, Burgess MW, Gillette MA, Jaffe JD, Carr SA.
 Nat Methods. 2013 Jul;10(7):634-7. [PMID: 23749302]
 [3] A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles.
 Wagner SA, Beli P, Weinert BT, Nielsen ML, Cox J, Mann M, Choudhary C.
 Mol Cell Proteomics. 2011 Oct;10(10):M111.013284. [PMID: 21890473
Functional Description
  
Sequence Annotation
  
Keyword
 Complete proteome; Metal-binding; Reference proteome; Zinc; Zinc-finger. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 1645 AA 
Protein Sequence
MDDDSLDELV ARSPGPDGHP QVGPADPAES SVGSSGDSGD DSDSEHGDGT DGEDEGASEE 60
EDLEDRSGSE DSEDDGETLL EVAGTQGKLE AAGSFNSDDD AESCPICLNA FRDQAVGTPE 120
NCAHYFCLDC IVEWSKNANS CPVDRTLFKC ICIRAQFGGK ILRKIPVENT KASEEEEDPT 180
FCEVCGRSDR EDRLLLCDGC DAGYHMECLD PPLQEVPVDE WFCPECAAPG VVLAADAGPV 240
SEEEVSLLLA DVVPTTSRLR PRAGRTRAIA RTRQSERVRA TVNRNRISTA RRVQHTPGRL 300
GSSLLDEAIE AVATGLSTAV YQRPLTPRTP ARRKRKTRRR KKVPGRKKTP SGPSAKSKSS 360
ATRSKKRQHR VKKRRGKKVK SEATTRSRIA RTLGLRRPVH SSCIPSVLKP VEPSLGLLRA 420
DIGAASLSLF GDPYELDPFD SSEELSANPL SPLSAKRRAL SRSALQSHQP VARPVSVGLS 480
RRRLPAAVPE PDLEEEPVPD LLGSILSGQS LLMLGSSDVI IHRDGSLSAK RAAPVSFQRN 540
SGSLSRGEEG FKGCLQPRAL PSGSPAQGPS GNRPQSTGLS CQGRSRTPAR TAGAPVRLDL 600
PAAPGAVQAR NLSNGSVPGF RQSHSPWFNG TNKHTLPLAS AASKISSRDS KPPCRSVVPG 660
PPLKPAPRRT DISELPRIPK IRRDDGGGRR DAAPAHGQSI EIPSACISRL TGREGTGQPG 720
RGTRAESEAS SRVPREPGVH TGSSRPPAPS SHGSLAPLGP SRGKGVGSTF ESFRINIPGN 780
MAHSSQLSSP GFCNTFRPVD DKEQRKENPS PLFSIKKTKQ LRSEVYDPSD PTGSDSSAPG 840
SSPERSGPGL LPSEITRTIS INSPKAQTVQ AVRCVTSYTV ESIFGTEPEP PLGPSSAMSK 900
LRGAVAAEGA SDTEREEPTE SQGLAARLRR PSPPEPWDEE DGASCSTFFG SEERTVTCVT 960
VVEPEAPPSP DVLQAATHRV VELRPPSRSR STSSSRSRKK AKRKRVSREH GRTRSGTRSE 1020
SRDRSSRSAS PSVGEERPRR QRSKAKSRRS SSDRSSSRER AKRKKAKDKS REHRRGPWGH 1080
SRRTSRSRSG SPGSSSYEHY ESRKKKKRRS ASRPRGRECS PTSSLERLCR HKHQRERSHE 1140
RPDRKESVAW PRDRRKRRSR SPSSEHRARE HRRPRSREKW PQTRSHSPER KGAVREASPA 1200
PLAQGEPGRE DLPTRLPALG EAHVSPEVAT ADKAPLQAPP VLEVAAECEP DDLDLDYGDS 1260
VEAGHVFDDF SSDAVFIQLD DMSSPPSPES TDSSPERDFP LKPALPPASL AVAAIQREVS 1320
LMHDEDPSQP PPLPEGTQEP HLLRPDAAEK AEAPSSPDVA PAGKEDSPSA SGRVQEAARP 1380
EEVVSQTPLL RSRALVKRVT WNLQESESSA PAEDRAPRAP LHRPQKPREG AWDMEDVAPT 1440
GVRQVFSELP FPSHVLPEPG FPDTDPSQVY SPGLPPAPAQ PSSIPPCALV SQPTVQFILQ 1500
GSLPLVGCGA AQTLAPVPAA LTPASEPASQ ATAASNSEEK TPAPRLAAEK TKKEEYMKKL 1560
HMQERAVEEV KLAIKPFYQK REVTKEEYKD ILRKAVQKIC HSKSGEINPV KVANLVKAYV 1620
DKYRHMRRHK KPEAGEEPPT QGAEG 1645 
Gene Ontology
 GO:0008270; F:zinc ion binding; IEA:InterPro. 
Interpro
 IPR019786; Zinc_finger_PHD-type_CS.
 IPR011011; Znf_FYVE_PHD.
 IPR001965; Znf_PHD.
 IPR019787; Znf_PHD-finger.
 IPR001841; Znf_RING.
 IPR013083; Znf_RING/FYVE/PHD.
 IPR017907; Znf_RING_CS. 
Pfam
 PF00628; PHD
 PF13639; zf-RING_2 
SMART
 SM00249; PHD
 SM00184; RING 
PROSITE
 PS01359; ZF_PHD_1
 PS50016; ZF_PHD_2
 PS00518; ZF_RING_1
 PS50089; ZF_RING_2 
PRINTS