| Tag | Content |
|---|
| CPLM ID | CPLM-001443 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | Myocyte-specific enhancer factor 2D |
Protein Synonyms/Alias | |
Gene Name | Mef2d |
Gene Synonyms/Alias | |
Created Date | July 27, 2013 |
Organism | Rattus norvegicus (Rat) |
NCBI Taxa ID | 10116 |
Lysine Modification | Position | Peptide | Type | References |
|---|
| 279 | VITSQGGKGLMHHLN | acetylation | [1] | | 497 | EAEGSAVKRMRLDTW | acetylation | [1] |
|
Reference | [1] Proteomic analysis of lysine acetylation sites in rat tissues reveals organ specificity and subcellular patterns. Lundby A, Lage K, Weinert BT, Bekker-Jensen DB, Secher A, Skovgaard T, Kelstrup CD, Dmytriyev A, Choudhary C, Lundby C, Olsen JV. Cell Rep. 2012 Aug 30;2(2):419-31. [ PMID: 22902405] |
Functional Description | Transcriptional activator which binds specifically to the MEF2 element, 5'-YTA[AT](4)TAR-3', found in numerous muscle- specific, growth factor- and stress-induced genes. Mediates cellular functions not only in skeletal and cardiac muscle development, but also in neuronal differentiation and survival. Plays diverse roles in the control of cell growth, survival and apoptosis via p38 MAPK signaling in muscle-specific and/or growth factor-related transcription. Plays a critical role in the regulation of neuronal apoptosis (By similarity). |
Sequence Annotation | DOMAIN 3 57 MADS-box.
DNA_BIND 58 86 Mef2-type (Potential).
MOD_RES 121 121 Phosphoserine; by PKA (By similarity).
MOD_RES 180 180 Phosphoserine; by MAPK7 (By similarity).
MOD_RES 190 190 Phosphoserine; by PKA (By similarity).
MOD_RES 231 231 Phosphoserine (By similarity).
MOD_RES 245 245 N6-acetyllysine (By similarity).
MOD_RES 251 251 Phosphoserine (By similarity).
MOD_RES 425 425 N6-acetyllysine; alternate.
MOD_RES 430 430 Phosphoserine (By similarity).
CROSSLNK 425 425 Glycyl lysine isopeptide (Lys-Gly) |
Keyword | Acetylation; Activator; Apoptosis; Complete proteome; Developmental protein; Differentiation; DNA-binding; Isopeptide bond; Neurogenesis; Nucleus; Phosphoprotein; Reference proteome; Transcription; Transcription regulation; Ubl conjugation. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 507 AA |
Protein Sequence | MGRKKIQIQR ITDERNRQVT FTKRKFGLMK KAYELSVLCD CEIALIIFNH SNKLFQYAST 60
DMDKVLLKYT EYNEPHESRT NADIIETLRK KGFNGCDSPE PDGEDSLEQS PLLEDKYRRA 120
SEELDGLFRR YGSSVPAPNF AMPVTVPVSN QSSMQFSNPS SSLVTPSLVT SSLTDPRLLS 180
PQQPALQRNS VSPGLPQRPA SAGAMLGRDL NSANGACPNP VGNGYVSARA SPGLLPVANG 240
NGLNKVIPAK SPPPPTHNTQ LGAPSRKPDL RVITSQGGKG LMHHLNNAQR LGVSQSTHSL 300
TTPVVSVATP SLLSQGLPFS SMPTAYNTDY QLPSAELSSL PAFSSPAGLA LGNVTAWQQP 360
QQPQQPQPPQ PPQSQPQPPQ PQPQQPPQQQ PHLVPVSLSN LIPGSPLPHV GAALTVTTHP 420
HISIKSEPVS PSRERSPAPP PPAVFPAARP EPGEGLSSPA GGSYETGDRD DGRGDFGPTL 480
GLLRPAPEPE AEGSAVKRMR LDTWTLK 507 |
Gene Ontology | GO:0005634; C:nucleus; IDA:UniProtKB. GO:0000977; F:RNA polymerase II regulatory region sequence-specific DNA binding; IEA:Compara. GO:0000981; F:sequence-specific DNA binding RNA polymerase II transcription factor activity; IEA:Compara. GO:0007512; P:adult heart development; IEA:Compara. GO:0006915; P:apoptotic process; IEA:UniProtKB-KW. GO:0002062; P:chondrocyte differentiation; IEA:Compara. GO:0001958; P:endochondral ossification; IEA:Compara. GO:0007399; P:nervous system development; IEA:UniProtKB-KW. GO:0001649; P:osteoblast differentiation; IEA:Compara. GO:0045944; P:positive regulation of transcription from RNA polymerase II promoter; IEA:Compara. GO:0045893; P:positive regulation of transcription, DNA-dependent; IMP:UniProtKB. |
Interpro | |
Pfam | |
SMART | |
PROSITE | |
PRINTS | |