UniProt Accession

 KBRS1_HUMAN; Q9NYS0; Q96K18 

Genbank Protein ID

 AF229839; AK027749; DQ314881; BC066940; BC012145 

Genbank Nucleotide ID

 AAF34998.1; BAB55341.1; ABC40740.1; AAH66940.1; AAH12145.1 

Protein Name

 NF-kappa-B inhibitor-interacting Ras-like protein 1 

Protein Synonyms/Alias

 I-kappa-B-interacting Ras-like protein 1; Kappa B-Ras protein 1; KappaB-Ras1 

Gene Name

 NKIRAS1 

Gene Synonyms/Alias

 KBRAS1 

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
140	EVAQQWAKSEKVRLW	ubiquitination	[1]
167	PFTLLASKLSQPQSK	ubiquitination	[1]

Reference

 [1] Systematic and quantitative assessment of the ubiquitin-modified proteome.
 Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
 Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983] 

Functional Description

 Atypical Ras-like protein that acts as a potent regulator of NF-kappa-B activity by preventing the degradation of NF-kappa-B inhibitor beta (NFKBIB) by most signals, explaining why NFKBIB is more resistant to degradation. May act by blocking phosphorylation of NFKBIB and mediating cytoplasmic retention of p65/RELA NF-kappa-B subunit. It is unclear whether it acts as a GTPase. Both GTP- and GDP-bound forms block phosphorylation of NFKBIB. 

Sequence Annotation

 NP_BIND 11 18 GTP (By similarity).
 NP_BIND 61 65 GTP (By similarity).
 NP_BIND 120 123 GTP (By similarity).
 REGION 58 93 Interactions with NFKBIA and NFKBIB.
 MOTIF 35 43 Effector region.  

Keyword

 Complete proteome; Cytoplasm; GTP-binding; Nucleotide-binding; Reference proteome. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 192 AA 

Protein Sequence

Gene Ontology

 GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
 GO:0016020; C:membrane; IEA:InterPro.
 GO:0005525; F:GTP binding; IEA:UniProtKB-KW.
 GO:0003924; F:GTPase activity; NAS:UniProtKB.
 GO:0007249; P:I-kappaB kinase/NF-kappaB cascade; NAS:UniProtKB.
 GO:0007264; P:small GTPase mediated signal transduction; IEA:InterPro. 

Interpro

 IPR027417; P-loop_NTPase.
 IPR005225; Small_GTP-bd_dom.
 IPR001806; Small_GTPase.
 IPR020849; Small_GTPase_Ras. 

Pfam

 PF00071; Ras 

SMART

  

PROSITE

 PS51419; RAB 

PRINTS

 PR00449; RASTRNSFRMNG.