CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-005112
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Calcium-transporting ATPase sarcoplasmic/endoplasmic reticulum type 
Protein Synonyms/Alias
 Calcium ATPase at 60A; Calcium pump 
Gene Name
 Ca-P60A 
Gene Synonyms/Alias
 CG3725 
Created Date
 July 27, 2013 
Organism
 Drosophila melanogaster (Fruit fly) 
NCBI Taxa ID
 7227 
Lysine Modification
Position
Peptide
Type
References
30GLTLDQIKANQKKYGacetylation[1]
Reference
 [1] Proteome-wide mapping of the Drosophila acetylome demonstrates a high degree of conservation of lysine acetylation.
 Weinert BT, Wagner SA, Horn H, Henriksen P, Liu WR, Olsen JV, Jensen LJ, Choudhary C.
 Sci Signal. 2011 Jul 26;4(183):ra48. [PMID: 21791702] 
Functional Description
 This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of calcium. 
Sequence Annotation
 ACT_SITE 351 351 4-aspartylphosphate intermediate (By
 METAL 304 304 Calcium 2; via carbonyl oxygen (By
 METAL 305 305 Calcium 2; via carbonyl oxygen (By
 METAL 307 307 Calcium 2; via carbonyl oxygen (By
 METAL 309 309 Calcium 2 (By similarity).
 METAL 703 703 Magnesium (By similarity).
 METAL 707 707 Magnesium (By similarity).
 METAL 768 768 Calcium 1 (By similarity).
 METAL 771 771 Calcium 1 (By similarity).
 METAL 796 796 Calcium 2 (By similarity).
 METAL 799 799 Calcium 1 (By similarity).
 METAL 800 800 Calcium 1 (By similarity).
 METAL 800 800 Calcium 2 (By similarity).
 METAL 908 908 Calcium 1 (By similarity).
 MOD_RES 240 240 Phosphoserine.  
Keyword
 Alternative splicing; ATP-binding; Calcium; Calcium transport; Complete proteome; Endoplasmic reticulum; Hydrolase; Ion transport; Magnesium; Membrane; Metal-binding; Nucleotide-binding; Phosphoprotein; Reference proteome; Sarcoplasmic reticulum; Transmembrane; Transmembrane helix; Transport. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 1020 AA 
Protein Sequence
MEDGHSKTVE QSLNFFGTDP ERGLTLDQIK ANQKKYGPNE LPTEEGKSIW QLVLEQFDDL 60
LVKILLLAAI ISFVLALFEE HEETFTAFVE PLVILLILIA NAVVGVWQER NAESAIEALK 120
EYEPEMGKVV RQDKSGIQKV RAKEIVPGDL VEVSVGDKIP ADIRITHIYS TTLRIDQSIL 180
TGESVSVIKH TDAIPDPRAV NQDKKNILFS GTNVAAGKAR GVVIGTGLST AIGKIRTEMS 240
ETEEIKTPLQ QKLDEFGEQL SKVISVICVA VWAINIGHFN DPAHGGSWIK GAIYYFKIAV 300
ALAVAAIPEG LPAVITTCLA LGTRRMAKKN AIVRSLPSVE TLGCTSVICS DKTGTLTTNQ 360
MSVSRMFIFD KVEGNDSSFL EFEMTGSTYE PIGEVFLNGQ RIKAADYDTL QELSTICIMC 420
NDSAIDYNEF KQAFEKVGEA TETALIVLAE KLNSFSVNKS GLDRRSAAIA CRGEIETKWK 480
KEFTLEFSRD RKSMSSYCTP LKASRLGTGP KLFVKGAPEG VLERCTHARV GTTKVPLTSA 540
LKAKILALTG QYGTGRDTLR CLALAVADSP MKPDEMDLGD STKFYQYEVN LTFVGVVGML 600
DPPRKEVFDS IVRCRAAGIR VIVITGDNKA TAEAICRRIG VFAEDEDTTG KSYSGREFDD 660
LSPTEQKAAV ARSRLFSRVE PQHKSKIVEF LQSMNEISAM TGDGVNDAPA LKKAEIGIAM 720
GSGTAVAKSA AEMVLADDNF SSIVSAVEEG RAIYNNMKQF IRYLISSNIG EVVSIFLTAA 780
LGLPEALIPV QLLWVNLVTD GLPATALGFN PPDLDIMEKP PRKADEGLIS GWLFFRYMAI 840
GFYVGAATVG AAAWWFVFSD EGPKLSYWQL THHLSCLGGG DEFKGVDCKI FSDPHAMTMA 900
LSVLVTIEML NAMNSLSENQ SLITMPPWCN LWLIGSMALS FTLHFVILYV DVLSTVFQVT 960
PLSAEEWITV MKFSIPVVLL DETLKFVARK IADGESPIYK MHGIVLMWAV FFGLLYAMML 1020 
Gene Ontology
 GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.
 GO:0005811; C:lipid particle; IDA:FlyBase.
 GO:0005635; C:nuclear envelope; IDA:FlyBase.
 GO:0016529; C:sarcoplasmic reticulum; ISS:UniProtKB.
 GO:0033017; C:sarcoplasmic reticulum membrane; IEA:UniProtKB-SubCell.
 GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
 GO:0005388; F:calcium-transporting ATPase activity; ISS:FlyBase.
 GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
 GO:0006874; P:cellular calcium ion homeostasis; IMP:FlyBase.
 GO:0007629; P:flight behavior; IGI:FlyBase.
 GO:0007274; P:neuromuscular synaptic transmission; IMP:FlyBase.
 GO:0051282; P:regulation of sequestering of calcium ion; IMP:FlyBase.
 GO:0030322; P:stabilization of membrane potential; IGI:FlyBase. 
Interpro
 IPR005782; ATPase_P-typ_Ca-transp_IIA.
 IPR006068; ATPase_P-typ_cation-transptr_C.
 IPR004014; ATPase_P-typ_cation-transptr_N.
 IPR023299; ATPase_P-typ_cyto_domN.
 IPR018303; ATPase_P-typ_P_site.
 IPR023298; ATPase_P-typ_TM_dom.
 IPR008250; ATPase_P-typ_transduc_dom_A.
 IPR001757; Cation_transp_P_typ_ATPase.
 IPR023214; HAD-like_dom. 
Pfam
 PF00689; Cation_ATPase_C
 PF00690; Cation_ATPase_N
 PF00122; E1-E2_ATPase
 PF00702; Hydrolase 
SMART
 SM00831; Cation_ATPase_N 
PROSITE
 PS00154; ATPASE_E1_E2 
PRINTS
 PR00119; CATATPASE.