CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-016040
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Plexin-A4 
Protein Synonyms/Alias
  
Gene Name
 Plxna4 
Gene Synonyms/Alias
 Kiaa1550 
Created Date
 July 27, 2013 
Organism
 Mus musculus (Mouse) 
NCBI Taxa ID
 10090 
Lysine Modification
Position
Peptide
Type
References
1414LLADLIDKNLESKNHubiquitination[1]
1801SNKLLYAKDIPSYKNubiquitination[1]
Reference
 [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023] 
Functional Description
 Coreceptor for SEMA3A. Necessary for signaling by class 3 semaphorins and subsequent remodeling of the cytoskeleton. Plays a role in axon guidance in the developing nervous system. Class 3 semaphorins bind to a complex composed of a neuropilin and a plexin. The plexin modulates the affinity of the complex for specific semaphorins, and its cytoplasmic domain is required for the activation of down-stream signaling events in the cytoplasm. 
Sequence Annotation
 DOMAIN 24 506 Sema.
 DOMAIN 508 558 PSI 1.
 DOMAIN 654 701 PSI 2.
 DOMAIN 802 855 PSI 3.
 DOMAIN 857 951 IPT/TIG 1.
 DOMAIN 953 1036 IPT/TIG 2.
 DOMAIN 1039 1138 IPT/TIG 3.
 DOMAIN 1141 1229 IPT/TIG 4.
 MOD_RES 1349 1349 N6-acetyllysine (By similarity).
 CARBOHYD 654 654 N-linked (GlcNAc...) (Potential).
 CARBOHYD 1006 1006 N-linked (GlcNAc...) (Potential).
 CARBOHYD 1131 1131 N-linked (GlcNAc...) (Potential).
 CARBOHYD 1179 1179 N-linked (GlcNAc...) (Potential).
 DISULFID 94 103 By similarity.
 DISULFID 129 137 By similarity.
 DISULFID 283 404 By similarity.
 DISULFID 299 355 By similarity.
 DISULFID 373 392 By similarity.
 DISULFID 509 526 By similarity.
 DISULFID 515 557 By similarity.
 DISULFID 518 535 By similarity.
 DISULFID 529 541 By similarity.
 DISULFID 592 611 By similarity.  
Keyword
 Acetylation; Cell membrane; Complete proteome; Disulfide bond; Glycoprotein; Membrane; Receptor; Reference proteome; Repeat; Signal; Transmembrane; Transmembrane helix. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 1893 AA 
Protein Sequence
MKAMPWNWTC LLSHLLVVGM GSSTLLPRQP PQLSQKPSFV TFRGEPAEGF NHLVVDERTG 60
HIYLGAVNRI YKLSSDLKVL VTHQTGPDED NPKCYPPRIV QTCNEPLAST NNVNKMLLID 120
YKENRLIACG SLYQGICKLL RLEDLFKLGE PFHKKEHYLS GVNESGSVFG VIVSYSNFDD 180
KLFIATAVDG KPEYFPTISS RKLTKNSEAD GMFAYVFHDE FVASMIKIPS DTFTVIPDFD 240
IYYVYGFSSG NFVYFLTLQP EMVSPPGSTT KEQVYTSKLV RLCKEDTAFN SYVEVPIGCE 300
RNGVEYRLLQ AAYLSKAGAV LGRTLGVRPD DDLLFTVFSK GQKRKMKSLD ESALCIFILK 360
QINDRIKDRL QSCYRGEGTL DLAWLKVKDI PCSSALLTID DNFCGLDMNA PLGVSEMVRG 420
IPVFTEDRDR MTSVIAYVYK NHSLAFVGTK SGKLKKIRVD GPKGNALQYE TVQVVDSGPV 480
LRDMAFSKDH EQLYIMSERQ LTRVPVESCG QYRSCGECLG SGDPHCGWCV LHNTCTRKER 540
CERSREPRRF ASEMKQCVRL TVHPNNISVS QYNVLLVLET YNVPELSAGV NCTFEDLSEM 600
DGLVIGNQIQ CYSPAAKEVP RIITENGDHH VVQLQLKSKE TGMTFASTSF VFYNCSVHNS 660
CLSCVESPYR CHWCKYRHVC THDPNTCSFQ EGRVKLPEDC PQLLRVDKIL VPVEVIKPIT 720
LKAKNLPQPQ SGQRGYECIL NIQGIEQRVP ALRFNSSSVQ CQNTSYSYEG MEINNLPVEL 780
TVVWNGHFNI DNPAQNKVYL YKCGAMRESC GLCLKADPDF ECGWCQSPGQ CTLRQHCPAH 840
ESRWLELSGA NSKCTNPRIT EIIPVTGPRE GGTKVTIRGE NLGLEFRDIA SHVKVAGVEC 900
SPLVDGYIPA EQIVCEMGEA KPSQHAGFVE ICVAVCRPEF MARSSQLYYF MTLTLADLKP 960
NRGPMSGGTQ VTITGTNLNA GSNVVVMFGS QPCLFHRRSP SYIICNTTSS EEVLDMKVTV 1020
QVDRARIRQD LVFQYVEDPT IVRIEPEWSI VSGNTPIAVW GTHLDLIQNP QIRAKHGGKE 1080
HINICEVLNA TEMTCQAPAL ALGPDHQSDL TERPEEFGFI LDNVQSLLIL NKTNFTYYPN 1140
PVFEAFSPSG ILELKPGTPI ILKGKNLIPP VAGGNVKLNY TVLVGEKPCT VTVSDVQLLC 1200
ESPNLIGRHK VMARVGGMEY SPGMVYIAPD SPLSLPAIVS IAVAGGLLII FIVAVLIAYK 1260
RKSRESDLTL KRLQMQMDNL ESRVALECKE AFAELQTDIH ELTSDLDGAG IPFLDYRTYT 1320
MRVLFPGIED HPVLRDLEVP GYRQERVEKG LKLFAQLINN KVFLLSFIRT LESQRSFSMR 1380
DRGNVASLIM TVLQSKLEYA TDVLKQLLAD LIDKNLESKN HPKLLLRRTE SVAEKMLTNW 1440
FTFLLYKFLK ECAGEPLFSL FCAIKQQMEK GPIDAITGEA RYSLSEDKLI RQQIEYKTLV 1500
LSCVSPDNVN SPEVPVKILN CDTITQVKEK ILDAIFKNVP CSHRPKAADM DLEWRQGSGA 1560
RMILQDEDIT TKIENDWKRL NTVAHYQVPD GSVVALVSKQ VTAYNAVNNS TVSRTSASKY 1620
ENMIRYTGSP DSLRSRTPMI TPDLESGVKL WHLVKNHEHG DQKEGDRGSK MVSEIYLTRL 1680
LATKGTLQKF VDDLFETIFS TAHRGSALPL AIKYMFDFLD EQADKHGIHD PHVRHTWKSN 1740
CLPLRFWVNM IKNPQFVFDI HKNSITDACL SVVAQTFMDS CSTSEHRLGK DSPSNKLLYA 1800
KDIPSYKNWV ERYYSDIGKM PAISDQDMNA YLAEQSRMHM NEFNTMSALS EIFSYVGKYS 1860
EEILGPLDHD DQCGKQKLAY KLEQVITLMS LDS 1893 
Gene Ontology
 GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.
 GO:0005622; C:intracellular; IEA:InterPro.
 GO:0005886; C:plasma membrane; ISS:MGI.
 GO:0017154; F:semaphorin receptor activity; IGI:MGI.
 GO:0021960; P:anterior commissure morphogenesis; IMP:MGI.
 GO:0021793; P:chemorepulsion of branchiomotor axon; IMP:MGI.
 GO:0021610; P:facial nerve morphogenesis; IMP:MGI.
 GO:0021615; P:glossopharyngeal nerve morphogenesis; IMP:MGI.
 GO:0021784; P:postganglionic parasympathetic nervous system development; IMP:MGI.
 GO:0048841; P:regulation of axon extension involved in axon guidance; IMP:MGI.
 GO:0050923; P:regulation of negative chemotaxis; IMP:MGI.
 GO:0048485; P:sympathetic nervous system development; IMP:MGI.
 GO:0021636; P:trigeminal nerve morphogenesis; IMP:MGI.
 GO:0021644; P:vagus nerve morphogenesis; IMP:MGI. 
Interpro
 IPR013783; Ig-like_fold.
 IPR014756; Ig_E-set.
 IPR002909; IPT_TIG_rcpt.
 IPR003659; Plexin-like.
 IPR016201; Plexin-like_fold.
 IPR013548; Plexin_cytoplasmic_RasGAP_dom.
 IPR002165; Plexin_repeat.
 IPR008936; Rho_GTPase_activation_prot.
 IPR001627; Semaphorin/CD100_Ag.
 IPR015943; WD40/YVTN_repeat-like_dom. 
Pfam
 PF08337; Plexin_cytopl
 PF01437; PSI
 PF01403; Sema
 PF01833; TIG 
SMART
 SM00429; IPT
 SM00423; PSI
 SM00630; Sema 
PROSITE
 PS51004; SEMA 
PRINTS