UniProt Accession

 SUOX_HUMAN; P51687 

Genbank Protein ID

 L31573; BC065193; AY056018 

Genbank Nucleotide ID

 AAA74886.1; AAH65193.2; AAL08048.1 

Protein Name

 Sulfite oxidase, mitochondrial 

Protein Synonyms/Alias

  

Gene Name

 SUOX 

Gene Synonyms/Alias

  

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
279	MTQVKEVKGLEWRTG	acetylation	[1]

Reference

 [1] Proteomic investigations reveal a role for RNA processing factor THRAP3 in the DNA damage response.
 Beli P, Lukashchuk N, Wagner SA, Weinert BT, Olsen JV, Baskcomb L, Mann M, Jackson SP, Choudhary C.
 Mol Cell. 2012 Apr 27;46(2):212-25. [PMID: 22424773] 

Functional Description

  

Sequence Annotation

 DOMAIN 82 161 Cytochrome b5 heme-binding.
 REGION 165 174 Hinge (By similarity).
 REGION 175 401 Moco domain (By similarity).
 REGION 215 219 Molybdopterin-binding (By similarity).
 REGION 377 379 Molybdopterin-binding (By similarity).
 REGION 402 538 Homodimerization (By similarity).
 METAL 118 118 Iron (heme axial ligand).
 METAL 143 143 Iron (heme axial ligand).
 METAL 264 264 Molybdenum (By similarity).
 BINDING 322 322 Molybdopterin (By similarity).
 BINDING 361 361 Molybdopterin (By similarity).
 BINDING 366 366 Molybdopterin (By similarity).
 MOD_RES 285 285 Phosphothreonine (By similarity).  

Keyword

 3D-structure; Complete proteome; Disease mutation; Heme; Iron; Metal-binding; Mitochondrion; Molybdenum; Oxidoreductase; Phosphoprotein; Reference proteome; Transit peptide. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 545 AA 

Protein Sequence

Gene Ontology

 GO:0005758; C:mitochondrial intermembrane space; IEA:UniProtKB-SubCell.
 GO:0005759; C:mitochondrial matrix; TAS:Reactome.
 GO:0009055; F:electron carrier activity; IEA:InterPro.
 GO:0020037; F:heme binding; IEA:InterPro.
 GO:0030151; F:molybdenum ion binding; IEA:InterPro.
 GO:0043546; F:molybdopterin cofactor binding; IEA:InterPro.
 GO:0008482; F:sulfite oxidase activity; TAS:Reactome.
 GO:0034641; P:cellular nitrogen compound metabolic process; TAS:Reactome.
 GO:0070221; P:sulfide oxidation, using sulfide:quinone oxidoreductase; TAS:Reactome.
 GO:0000098; P:sulfur amino acid catabolic process; TAS:Reactome. 

Interpro

 IPR001199; Cyt_B5-like_heme/steroid-bd.
 IPR018506; Cyt_B5_heme-BS.
 IPR014756; Ig_E-set.
 IPR005066; MoCF_OxRdtse_dimer.
 IPR008335; Mopterin_OxRdtase_euk.
 IPR000572; OxRdtase_Mopterin-bd_dom.
 IPR022407; OxRdtase_Mopterin_BS. 

Pfam

 PF00173; Cyt-b5
 PF03404; Mo-co_dimer
 PF00174; Oxidored_molyb 

SMART

  

PROSITE

 PS00191; CYTOCHROME_B5_1
 PS50255; CYTOCHROME_B5_2
 PS00559; MOLYBDOPTERIN_EUK 

PRINTS

 PR00363; CYTOCHROMEB5.
 PR00407; EUMOPTERIN.