UniProt Accession

 PPID_YEAST; P53691; D6VYL7; Q6Q5K7 

Genbank Protein ID

 U48867; U14913; AY557959; BK006945 

Genbank Nucleotide ID

 AAC49414.1; AAB67445.1; AAS56285.1; DAA09533.1 

Protein Name

 Peptidyl-prolyl cis-trans isomerase CPR6 

Protein Synonyms/Alias

 PPIase CPR6; Rotamase CPR6 

Gene Name

 CPR6 

Gene Synonyms/Alias

 YLR216C; L8167.24 

Created Date

 July 27, 2013 

Organism

 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) 

NCBI Taxa ID

 559292 

Lysine Modification

Position	Peptide	Type	References
100	EDENFTVKHDKPFLL	acetylation	[1]
162	QCDQENNKPLRDVKI	ubiquitination	[2]
210	QDEKVDLKNFDTVLK	acetylation	[1]
210	QDEKVDLKNFDTVLK	ubiquitination	[2]
223	LKAIETVKNIGTEQF	acetylation	[1]
223	LKAIETVKNIGTEQF	ubiquitination	[2]
231	NIGTEQFKKQNYSVA	acetylation	[1]
231	NIGTEQFKKQNYSVA	ubiquitination	[2]
232	IGTEQFKKQNYSVAL	ubiquitination	[2]
241	NYSVALEKYVKCDKF	acetylation	[1]
259	YFPEDLEKEQIEKIN	ubiquitination	[2]
264	LEKEQIEKINQLKVS	acetylation	[1]

Reference

 [1] Proteome-wide analysis of lysine acetylation suggests its broad regulatory scope in Saccharomyces cerevisiae.
 Henriksen P, Wagner SA, Weinert BT, Sharma S, Bacinskaja G, Rehman M, Juffer AH, Walther TC, Lisby M, Choudhary C.
 Mol Cell Proteomics. 2012 Nov;11(11):1510-22. [PMID: 22865919]
 [2] Global analysis of phosphorylation and ubiquitylation cross-talk in protein degradation.
 Swaney DL, Beltrao P, Starita L, Guo A, Rush J, Fields S, Krogan NJ, Villén J.
 Nat Methods. 2013 Jul;10(7):676-82. [PMID: 23749301] 

Functional Description

 PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides. 

Sequence Annotation

 DOMAIN 7 174 PPIase cyclophilin-type.
 REPEAT 219 252 TPR 1.
 REPEAT 270 303 TPR 2.
 REPEAT 308 341 TPR 3.  

Keyword

 Complete proteome; Cytoplasm; Isomerase; Reference proteome; Repeat; Rotamase; TPR repeat. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 371 AA 

Protein Sequence

Gene Ontology

 GO:0005737; C:cytoplasm; IDA:SGD.
 GO:0003755; F:peptidyl-prolyl cis-trans isomerase activity; IDA:SGD.
 GO:0051082; F:unfolded protein binding; IDA:SGD.
 GO:0042026; P:protein refolding; IDA:SGD. 

Interpro

 IPR002130; Cyclophilin-like_PPIase_dom.
 IPR020892; Cyclophilin-type_PPIase_CS.
 IPR023114; Elongated_TPR_rpt_dom.
 IPR001440; TPR-1.
 IPR013026; TPR-contain_dom.
 IPR011990; TPR-like_helical.
 IPR019734; TPR_repeat. 

Pfam

 PF00160; Pro_isomerase
 PF00515; TPR_1 

SMART

  

PROSITE

 PS00170; CSA_PPIASE_1
 PS50072; CSA_PPIASE_2
 PS50005; TPR
 PS50293; TPR_REGION 

PRINTS

 PR00153; CSAPPISMRASE.