UniProt Accession

 DYL1_RAT; P63170; Q15701 

Genbank Protein ID

 U66461; BC063183 

Genbank Nucleotide ID

 AAB38257.1; AAH63183.1 

Protein Name

 Dynein light chain 1, cytoplasmic 

Protein Synonyms/Alias

 8 kDa dynein light chain; DLC8; Dynein light chain LC8-type 1; Protein inhibitor of neuronal nitric oxide synthase; PIN 

Gene Name

 Dynll1 

Gene Synonyms/Alias

 Dncl1; Dnclc1; Pin 

Created Date

 July 27, 2013 

Organism

 Rattus norvegicus (Rat) 

NCBI Taxa ID

 10116 

Lysine Modification

Position	Peptide	Type	References
9	CDRKAVIKNADMSEE	acetylation	[1]
36	LEKYNIEKDIAAHIK	acetylation	[1]
36	LEKYNIEKDIAAHIK	ubiquitination	[2]
43	KDIAAHIKKEFDKKY	acetylation	[1]
49	IKKEFDKKYNPTWHC	acetylation	[1]

Reference

 [1] Proteomic analysis of lysine acetylation sites in rat tissues reveals organ specificity and subcellular patterns.
 Lundby A, Lage K, Weinert BT, Bekker-Jensen DB, Secher A, Skovgaard T, Kelstrup CD, Dmytriyev A, Choudhary C, Lundby C, Olsen JV.
 Cell Rep. 2012 Aug 30;2(2):419-31. [PMID: 22902405]
 [2] Synaptic protein ubiquitination in rat brain revealed by antibody-based ubiquitome analysis.
 Na CH, Jones DR, Yang Y, Wang X, Xu Y, Peng J.
 J Proteome Res. 2012 Sep 7;11(9):4722-32. [PMID: 22871113] 

Functional Description

 Acts as one of several non-catalytic accessory components of the cytoplasmic dynein 1 complex that are thought to be involved in linking dynein to cargos and to adapter proteins that regulate dynein function. Cytoplasmic dynein 1 acts as a motor for the intracellular retrograde motility of vesicles and organelles along microtubules. May play a role in changing or maintaining the spatial distribution of cytoskeletal structures. 

Sequence Annotation

 REGION 67 89 Interaction with ESR1 (By similarity).
 MOD_RES 36 36 N6-acetyllysine (By similarity).
 MOD_RES 88 88 Phosphoserine (By similarity).  

Keyword

 3D-structure; Acetylation; Activator; Apoptosis; Complete proteome; Cytoplasm; Cytoskeleton; Direct protein sequencing; Dynein; Microtubule; Mitochondrion; Motor protein; Nucleus; Phosphoprotein; Reference proteome; Transcription; Transcription regulation; Transport. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 89 AA 

Protein Sequence

Gene Ontology

 GO:0005813; C:centrosome; IEA:Compara.
 GO:0005868; C:cytoplasmic dynein complex; IDA:UniProtKB.
 GO:0005829; C:cytosol; IEA:Compara.
 GO:0000776; C:kinetochore; ISS:UniProtKB.
 GO:0016020; C:membrane; IEA:Compara.
 GO:0005874; C:microtubule; IEA:UniProtKB-KW.
 GO:0005739; C:mitochondrion; IEA:UniProtKB-SubCell.
 GO:0072686; C:mitotic spindle; ISS:UniProtKB.
 GO:0008180; C:signalosome; IEA:Compara.
 GO:0004857; F:enzyme inhibitor activity; TAS:ProtInc.
 GO:0003774; F:motor activity; IEA:UniProtKB-KW.
 GO:0030235; F:nitric-oxide synthase regulator activity; IDA:RGD.
 GO:0042803; F:protein homodimerization activity; IDA:RGD.
 GO:0006915; P:apoptotic process; IEA:UniProtKB-KW.
 GO:0007017; P:microtubule-based process; IEA:InterPro.
 GO:0042326; P:negative regulation of phosphorylation; IEA:Compara.
 GO:0042133; P:neurotransmitter metabolic process; TAS:ProtInc.
 GO:0006809; P:nitric oxide biosynthetic process; TAS:ProtInc.
 GO:0006355; P:regulation of transcription, DNA-dependent; IEA:UniProtKB-KW.
 GO:0006351; P:transcription, DNA-dependent; IEA:UniProtKB-KW.
 GO:0006810; P:transport; IEA:UniProtKB-KW. 

Interpro

 IPR019763; Dynein_light_1/2_CS.
 IPR001372; Dynein_light_chain_typ-1/2. 

Pfam

 PF01221; Dynein_light 

SMART

  

PROSITE

 PS01239; DYNEIN_LIGHT_1 

PRINTS