CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-016276
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Protein NLRC5 
Protein Synonyms/Alias
 Caterpiller protein 16.1; CLR16.1; Nucleotide-binding oligomerization domain protein 27; Nucleotide-binding oligomerization domain protein 4 
Gene Name
 NLRC5 
Gene Synonyms/Alias
 NOD27; NOD4 
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
989THCGLQEKHLEQLCKubiquitination[1, 2]
996KHLEQLCKALGGSCHubiquitination[2]
1099PDFPAAAKFLGFRQRubiquitination[2]
1241SLCWLLSKCKDLSQVubiquitination[2]
1243CWLLSKCKDLSQVDLubiquitination[2]
1349RLATGLSKSLQLTELubiquitination[2]
1549LMRALEGKWMLKRLDubiquitination[2]
1751QIDLVSCKIDNQTAKubiquitination[2]
1845CDMAQHLKSQEPRLDubiquitination[2]
Reference
 [1] Methods for quantification of in vivo changes in protein ubiquitination following proteasome and deubiquitinase inhibition.
 Udeshi ND, Mani DR, Eisenhaure T, Mertins P, Jaffe JD, Clauser KR, Hacohen N, Carr SA.
 Mol Cell Proteomics. 2012 May;11(5):148-59. [PMID: 22505724]
 [2] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961] 
Functional Description
 Probable regulator of the NF-kappa-B and type I interferon signaling pathways. May also regulate the type II interferon signaling pathway. Plays a role in homeostatic control of innate immunity and in antiviral defense mechanisms. 
Sequence Annotation
 DOMAIN 222 539 NACHT.
 REPEAT 599 622 LRR 1.
 REPEAT 713 737 LRR 2.
 REPEAT 741 765 LRR 3.
 REPEAT 769 792 LRR 4.
 REPEAT 869 892 LRR 5.
 REPEAT 897 921 LRR 6.
 REPEAT 930 953 LRR 7.
 REPEAT 976 1000 LRR 8.
 REPEAT 1004 1026 LRR 9.
 REPEAT 1031 1058 LRR 10.
 REPEAT 1138 1161 LRR 11.
 REPEAT 1162 1184 LRR 12.
 REPEAT 1242 1265 LRR 13.
 REPEAT 1272 1294 LRR 14.
 REPEAT 1462 1488 LRR 15.
 REPEAT 1493 1516 LRR 16.
 REPEAT 1521 1544 LRR 17.
 REPEAT 1554 1577 LRR 18.
 REPEAT 1578 1600 LRR 19.
 REPEAT 1605 1628 LRR 20.
 REPEAT 1633 1656 LRR 21.
 REPEAT 1661 1684 LRR 22.
 REPEAT 1687 1714 LRR 23.
 REPEAT 1715 1739 LRR 24.
 REPEAT 1741 1762 LRR 25.
 REPEAT 1795 1818 LRR 26.
 NP_BIND 228 235 ATP (Potential).  
Keyword
 Alternative splicing; ATP-binding; Complete proteome; Cytoplasm; Immunity; Innate immunity; Leucine-rich repeat; Nucleotide-binding; Polymorphism; Reference proteome; Repeat. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 1866 AA 
Protein Sequence
MDPVGLQLGN KNLWSCLVRL LTKDPEWLNA KMKFFLPNTD LDSRNETLDP EQRVILQLNK 60
LHVQGSDTWQ SFIHCVCMQL EVPLDLEVLL LSTFGYDDGF TSQLGAEGKS QPESQLHHGL 120
KRPHQSCGSS PRRKQCKKQQ LELAKKYLQL LRTSAQQRYR SQIPGSGQPH AFHQVYVPPI 180
LRRATASLDT PEGAIMGDVK VEDGADVSIS DLFNTRVNKG PRVTVLLGKA GMGKTTLAHR 240
LCQKWAEGHL NCFQALFLFE FRQLNLITRF LTPSELLFDL YLSPESDHDT VFQYLEKNAD 300
QVLLIFDGLD EALQPMGPDG PGPVLTLFSH LCNGTLLPGC RVMATSRPGK LPACLPAEAA 360
MVHMLGFDGP RVEEYVNHFF SAQPSREGAL VELQTNGRLR SLCAVPALCQ VACLCLHHLL 420
PDHAPGQSVA LLPNMTQLYM QMVLALSPPG HLPTSSLLDL GEVALRGLET GKVIFYAKDI 480
APPLIAFGAT HSLLTSFCVC TGPGHQQTGY AFTHLSLQEF LAALHLMASP KVNKDTLTQY 540
VTLHSRWVQR TKARLGLSDH LPTFLAGLAS CTCRPFLSHL AQGNEDCVGA KQAAVVQVLK 600
KLATRKLTGP KVVELCHCVD ETQEPELASL TAQSLPYQLP FHNFPLTCTD LATLTNILEH 660
REAPIHLDFD GCPLEPHCPE ALVGCGQIEN LSFKSRKCGD AFAEALSRSL PTMGRLQMLG 720
LAGSKITARG ISHLVKALPL CPQLKEVSFR DNQLSDQVVL NIVEVLPHLP RLRKLDLSSN 780
SICVSTLLCL ARVAVTCPTV RMLQAREADL IFLLSPPTET TAELQRAPDL QESDGQRKGA 840
QSRSLTLRLQ KCQLQVHDAE ALIALLQEGP HLEEVDLSGN QLEDEGCRLM AEAASQLHIA 900
RKLDLSNNGL SVAGVHCVLR AVSACWTLAE LHISLQHKTV IFMFAQEPEE QKGPQERAAF 960
LDSLMLQMPS ELPLSSRRMR LTHCGLQEKH LEQLCKALGG SCHLGHLHLD FSGNALGDEG 1020
AARLAQLLPG LGALQSLNLS ENGLSLDAVL GLVRCFSTLQ WLFRLDISFE SQHILLRGDK 1080
TSRDMWATGS LPDFPAAAKF LGFRQRCIPR SLCLSECPLE PPSLTRLCAT LKDCPGPLEL 1140
QLSCEFLSDQ SLETLLDCLP QLPQLSLLQL SQTGLSPKSP FLLANTLSLC PRVKKVDLRS 1200
LHHATLHFRS NEEEEGVCCG RFTGCSLSQE HVESLCWLLS KCKDLSQVDL SANLLGDSGL 1260
RCLLECLPQV PISGLLDLSH NSISQESALY LLETLPSCPR VREASVNLGS EQSFRIHFSR 1320
EDQAGKTLRL SECSFRPEHV SRLATGLSKS LQLTELTLTQ CCLGQKQLAI LLSLVGRPAG 1380
LFSLRVQEPW ADRARVLSLL EVCAQASGSV TEISISETQQ QLCVQLEFPR QEENPEAVAL 1440
RLAHCDLGAH HSLLVGQLME TCARLQQLSL SQVNLCEDDD ASSLLLQSLL LSLSELKTFR 1500
LTSSCVSTEG LAHLASGLGH CHHLEELDLS NNQFDEEGTK ALMRALEGKW MLKRLDLSHL 1560
LLNSSTLALL THRLSQMTCL QSLRLNRNSI GDVGCCHLSE ALRAATSLEE LDLSHNQIGD 1620
AGVQHLATIL PGLPELRKID LSGNSISSAG GVQLAESLVL CRRLEELMLG CNALGDPTAL 1680
GLAQELPQHL RVLHLPFSHL GPGGALSLAQ ALDGSPHLEE ISLAENNLAG GVLRFCMELP 1740
LLRQIDLVSC KIDNQTAKLL TSSFTSCPAL EVILLSWNLL GDEAAAELAQ VLPQMGRLKR 1800
VDLEKNQITA LGAWLLAEGL AQGSSIQVIR LWNNPIPCDM AQHLKSQEPR LDFAFFDNQP 1860
QAPWGT 1866 
Gene Ontology
 GO:0005829; C:cytosol; IDA:BHF-UCL.
 GO:0005634; C:nucleus; IDA:BHF-UCL.
 GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
 GO:0000979; F:RNA polymerase II core promoter sequence-specific DNA binding; IDA:BHF-UCL.
 GO:0051607; P:defense response to virus; IEP:UniProtKB.
 GO:0045087; P:innate immune response; IMP:UniProtKB.
 GO:0032088; P:negative regulation of NF-kappaB transcription factor activity; IDA:UniProtKB.
 GO:0032480; P:negative regulation of type I interferon production; TAS:Reactome.
 GO:0060339; P:negative regulation of type I interferon-mediated signaling pathway; IDA:UniProtKB.
 GO:0060335; P:positive regulation of interferon-gamma-mediated signaling pathway; IDA:UniProtKB.
 GO:0045345; P:positive regulation of MHC class I biosynthetic process; IDA:BHF-UCL.
 GO:0045944; P:positive regulation of transcription from RNA polymerase II promoter; IDA:BHF-UCL.
 GO:0060340; P:positive regulation of type I interferon-mediated signaling pathway; IDA:UniProtKB.
 GO:0043549; P:regulation of kinase activity; IDA:UniProtKB. 
Interpro
 IPR001611; Leu-rich_rpt.
 IPR025875; Leu-rich_rpt_4.
 IPR007111; NACHT_NTPase.
 IPR027417; P-loop_NTPase. 
Pfam
 PF12799; LRR_4 
SMART
  
PROSITE
 PS51450; LRR
 PS50837; NACHT 
PRINTS