UniProt Accession

 TXD12_MOUSE; Q9CQU0; Q53YN1 

Genbank Protein ID

 AY548113; AK003481; AK002862; BC006857 

Genbank Nucleotide ID

 AAS55653.1; BAB22811.1; BAB22413.1; AAH06857.1 

Protein Name

 Thioredoxin domain-containing protein 12 

Protein Synonyms/Alias

 Endoplasmic reticulum resident protein 19; ER protein 19; ERp19; Thioredoxin-like protein p19 

Gene Name

 Txndc12 

Gene Synonyms/Alias

 Tlp19 

Created Date

 July 27, 2013 

Organism

 Mus musculus (Mouse) 

NCBI Taxa ID

 10090 

Lysine Modification

Position	Peptide	Type	References
68	KSWCGACKALKPKFA	acetylation	[1]

Reference

 [1] Quantitative acetylome analysis reveals the roles of SIRT1 in regulating diverse substrates and cellular pathways.
 Chen Y, Zhao W, Yang JS, Cheng Z, Luo H, Lu Z, Tan M, Gu W, Zhao Y.
 Mol Cell Proteomics. 2012 Oct;11(10):1048-62. [PMID: 22826441] 

Functional Description

 Possesses significant protein thiol-disulfide oxidase activity (By similarity). 

Sequence Annotation

 MOTIF 167 170 Prevents secretion from ER (Potential).
 CARBOHYD 128 128 N-linked (GlcNAc...) (Potential).
 DISULFID 64 67 Redox-active (Potential).  

Keyword

 Complete proteome; Disulfide bond; Endoplasmic reticulum; Glycoprotein; Oxidoreductase; Redox-active center; Reference proteome; Signal. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 170 AA 

Protein Sequence

Gene Ontology

 GO:0005788; C:endoplasmic reticulum lumen; IEA:UniProtKB-SubCell.
 GO:0019153; F:protein-disulfide reductase (glutathione) activity; IEA:EC.
 GO:0045454; P:cell redox homeostasis; IEA:InterPro. 

Interpro

 IPR012336; Thioredoxin-like_fold.
 IPR017937; Thioredoxin_CS. 

Pfam

  

SMART

  

PROSITE

 PS00014; ER_TARGET
 PS00194; THIOREDOXIN_1
 PS51352; THIOREDOXIN_2 

PRINTS