CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-038285
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
  
Protein Name
 Desmoplakin 
Protein Synonyms/Alias
  
Gene Name
 Dsp 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Mus musculus (Mouse) 
NCBI Taxa ID
 10090 
Lysine Modification
Position
Peptide
Type
References
152QPCDAYQKRLLQLQEubiquitination[1]
166EQMRALYKAISVPRVubiquitination[1]
197SGWDEFTKRLTGECLubiquitination[1]
453QVQNLVNKSKKIVQLubiquitination[1]
482LRALCDYKQDQKIVHubiquitination[1]
841KSLLATMKTELQKAQubiquitination[1]
1045DLKLKNTKIEVLEEEubiquitination[1]
1085QAECSQFKAKLVSLEubiquitination[1]
1156NDYDQLQKARQCEKEubiquitination[1]
1287WKTQYSRKEETIRKIacetylation[2]
1293RKEETIRKIESEREKacetylation[2]
2115FIGFEGVKGKKKMSAubiquitination[1]
2127MSAAEAVKEKWLPYEubiquitination[1]
2129AAEAVKEKWLPYEAGubiquitination[1]
2185QDISSYAKILTCPKTubiquitination[1]
2224EAASVSSKGLPSPYNubiquitination[1]
Reference
 [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023]
 [2] Label-free quantitative proteomics of the lysine acetylome in mitochondria identifies substrates of SIRT3 in metabolic pathways.
 Rardin MJ, Newman JC, Held JM, Cusack MP, Sorensen DJ, Li B, Schilling B, Mooney SD, Kahn CR, Verdin E, Gibson BW.
 Proc Natl Acad Sci U S A. 2013 Apr 16;110(16):6601-6. [PMID: 23576753] 
Functional Description
  
Sequence Annotation
  
Keyword
 Complete proteome; Reference proteome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 2284 AA 
Protein Sequence
MSCNGGSHPR INTLGRMTRA ESGPDLRYEM TYSGGGGGGG GGGGGGTSRT FYSHSRRCTV 60
NDQNSDGYCQ TGTMSRHQNQ NTIQEMLQNC SDCLMRAELI AQPELKFGEG MQLAWNRELD 120
EYFTQANDQM EIIDGLIREM RQMGQPCDAY QKRLLQLQEQ MRALYKAISV PRVRRASSKG 180
AGGYTCQSGS GWDEFTKRLT GECLGWMRQQ REEMDLMAWG VDAGSVEQHI NSHRSIHNTI 240
GDYRWQLDKI KADLREKSAI YQLEEEYENL LKASFERMDH LRQLQNIIQA TSREIMWIND 300
CEEEELLYDW SDKNTNIAQK QEAFSIRMSQ LEVKEKELNK LKQESDQLVL NQHPASDKIE 360
AYMDTLQTQW SWILQITKCI DVHLKENAAY FQFFEEAQST EAYLKGLQDS IRKKYPCDKN 420
MPLQHLLEQI KELEKEREKI IEYKRQVQNL VNKSKKIVQL KPRNPDYRSN KPIILRALCD 480
YKQDQKIVHK GDECILKDNN ERSKWYVTGP GGVDMLVPSV GLIIPPPNPL AVDLSCKIEQ 540
YYEAILALWN QLYINMKSLV SWHYCMIDIE KIRAMTIAKL KTMRQEDYMK TIEDLELHYQ 600
DFIKNSQGSE MFGDDDKRRM QSQFTDAQKH YQTLVIQLPG HPQHQTVTKT EITHLGTCQD 660
VNHNKVIETN RENDKQETWL LMELQKIRRQ MEHCEARMTL KNLLLAEQGS THHITVKINE 720
LKSVQNDSQA LAEVLNQLKD MLANFRGSEK YCYLQNEIFG LFQKLENING VSDGYLNSLC 780
SVRALLQAIL QTEDMLKVYE ARLTEEETVC LDLDKVEAYR CGLKKIKNDL NLKKSLLATM 840
KTELQKAQQI HSQSSQQYPL YDLDLGKFTE KVTQLTDRWQ KIDKQIDFRL WDLEKQIKQL 900
RNYRDNYQSF CKWLYDAKRR QDSLESMKFG DSNTVMRFLN EQKNLHSEIS GKRDKSEEVH 960
KIAELCANSI KDYELQLASY TSGLETLLNI PIKRTMVQSP SGVILQEAAD IHARYIELLT 1020
RSGDYYRFLS EMLKSLEDLK LKNTKIEVLE EELRLARDAN SENCNKNKFL DQNLQKYQAE 1080
CSQFKAKLVS LEELKRQAEL DGKSAKQNLD KCYGQIKELN EKITRLTYEI EDEKRRRKTV 1140
EDRFDQQKND YDQLQKARQC EKENLSWQKL ESEKAIKEKE YEIERLRVLL QEEGARKREY 1200
ENELAKASNR IQESKSQCTQ VVQERESLLV KIKVLEQDKA RLQRLEDELN RAKATLEAES 1260
RVKQRLECEK QQIQNDLNQW KTQYSRKEET IRKIESEREK SEREKNSLRS EIERLQAEIK 1320
RIEERCRRKL EDSSRETQSQ LESERCRLQK EIEKLRQRPY GSHRETQTEY EWTVDSSKLV 1380
FDGLRKKVTA MQLYECQLID KTTLDKLLKG KKSVEEVASE IQPFLRGAGA IAGASASPKE 1440
KYSLVEAKRK KFITPESTVM LLEAQAATGG IIDPHRNEKL TVDNAVARDL IDFDDRQQIY 1500
TAEKAITGFD DPFSGKTVSV SEAIKKNLID RETGMRLLEA QLASGGVVDP VNSVFLPKDV 1560
ALARGLIDRD LYRSLNDPRD SQKNFVDPIT KKKVSYMQLR ERCRIEPHTG LLLLSVQKRS 1620
MSFQGIRQPV TVTELVDSGI LRPSTVNELE SGQISYDEVG ERIKDFLQGS SCIAGIYNET 1680
TKQKLGIYEA MKIGLVRPGT ALELLEAQAA TGFIVDPVSN LRLPVEEAYK RGLVGIEFKE 1740
KLLSAERAVT GYNDPETGNI ISLFQAMNKE LIEKGHGIRL LEAQIATGGI IDPKESHRLP 1800
VDMAYKRGYF NEELSEILSD PSDDTKGFFD PNTEENLTYL QLKERCIKDE ETGLCLLPLK 1860
EKKKQVQTSQ KNTLRKRRVV IVDPETNKEM SVQEAYKKGL IDYDTFKELC EQECEWEEIT 1920
ITGSDGSTRV VLVDRKTGSQ YDIQDAIDKG LVDRKFFDQY RSGSLSLTQF ADMISLKNGV 1980
GNSSGLGGSV NDDVFSSSRH DSVSKISTIS SVRNLTIRSS SLSDPLEESS PIAAIFDTEN 2040
LEKISIAEGI ERGIVDSITG QRLLEAQACT GGIIHPTTGQ KLSLQDAVNQ GLIDQDMATR 2100
LKPAQKAFIG FEGVKGKKKM SAAEAVKEKW LPYEAGQRFL EFQFLTGGLV DPEVHGRIST 2160
EEAIRKGFID GRAAQRLQDI SSYAKILTCP KTKLKISYKD AMNRSMVEDI TGLRLLEAAS 2220
VSSKGLPSPY NMSAPGSRSG SRSGSRSGSR SGSRSGSRRG SFDATGNSSY SYSYSFSSSS 2280
IGGY 2284 
Gene Ontology
 GO:0016323; C:basolateral plasma membrane; IDA:MGI.
 GO:0005856; C:cytoskeleton; IEA:InterPro.
 GO:0030057; C:desmosome; IDA:MGI.
 GO:0014704; C:intercalated disc; IDA:MGI.
 GO:0005739; C:mitochondrion; IDA:MGI.
 GO:0034332; P:adherens junction organization; IMP:MGI.
 GO:0016337; P:cell-cell adhesion; IMP:MGI.
 GO:0002934; P:desmosome organization; IMP:MGI.
 GO:0045104; P:intermediate filament cytoskeleton organization; IMP:MGI.
 GO:0043588; P:skin development; IMP:MGI. 
Interpro
 IPR001101; Plectin_repeat.
 IPR018159; Spectrin/alpha-actinin. 
Pfam
 PF00681; Plectin 
SMART
 SM00250; PLEC
 SM00150; SPEC 
PROSITE
  
PRINTS