CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-007785
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Moesin/ezrin/radixin homolog 1 
Protein Synonyms/Alias
 Ezrin-moesin-radixin 1; Moesin; dMoesin; Protein D17 
Gene Name
 Moe 
Gene Synonyms/Alias
 EMR1; CG10701 
Created Date
 July 27, 2013 
Organism
 Drosophila melanogaster (Fruit fly) 
NCBI Taxa ID
 7227 
Lysine Modification
Position
Peptide
Type
References
61KGDSTWIKLYKKVMNacetylation[1]
140ARHGDHNKTTHTAGFacetylation[1]
254RNISFSEKKFIIKPIacetylation[1]
259SEKKFIIKPIDKKAPacetylation[1]
380LKQLQAAKDELELRQacetylation[1]
524ERLHDQLKALKQDLAacetylation[1]
Reference
 [1] Proteome-wide mapping of the Drosophila acetylome demonstrates a high degree of conservation of lysine acetylation.
 Weinert BT, Wagner SA, Horn H, Henriksen P, Liu WR, Olsen JV, Jensen LJ, Choudhary C.
 Sci Signal. 2011 Jul 26;4(183):ra48. [PMID: 21791702] 
Functional Description
 Involved in connections of major cytoskeletal structures to the plasma membrane. 
Sequence Annotation
 DOMAIN 1 296 FERM.  
Keyword
 Actin-binding; Alternative splicing; Cell junction; Cell membrane; Complete proteome; Cytoplasm; Cytoskeleton; Membrane; Reference proteome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 578 AA 
Protein Sequence
MSPKALNVRV TTMDAELEFA IQSTTTGKQL FDQVVKTIGL REVWFFGLQY TDSKGDSTWI 60
KLYKKVMNQD VKKENPLQFR FRAKFYPEDV AEELIQDITL RLFYLQVKNA ILTDEIYCPP 120
ETSVLLASYA VQARHGDHNK TTHTAGFLAN DRLLPQRVID QHKMSKDEWE QSIMTWWQEH 180
RSMLREDAMM EYLKIAQDLE MYGVNYFEIR NKKGTDLWLG VDALGLNIYE QDDRLTPKIG 240
FPWSEIRNIS FSEKKFIIKP IDKKAPDFMF FAPRVRINKR ILALCMGNHE LYMRRRKPDT 300
IDVQQMKAQA REEKNAKQQE REKLQLALAA RERAEKKQQE YEDRLKQMQE DMERSQRDLL 360
EAQDMIRRLE EQLKQLQAAK DELELRQKEL QAMLQRLEEA KNMEAVEKLK LEEEIMAKQM 420
EVQRIQDEVN AKDEETKRLQ DEVEDARRKQ VIAAEAAAAL LAASTTPQHH HVAEDENENE 480
EELTNGDAGG DVSRDLDTDE HIKDPIEDRR TLAERNERLH DQLKALKQDL AQSRDETKET 540
ANDKIHRENV RQGRDKYKTL REIRKGNTKR RVDQFENM 578 
Gene Ontology
 GO:0005912; C:adherens junction; IDA:UniProtKB.
 GO:0005938; C:cell cortex; IDA:FlyBase.
 GO:0005856; C:cytoskeleton; IEA:UniProtKB-SubCell.
 GO:0019898; C:extrinsic to membrane; IEA:InterPro.
 GO:0005634; C:nucleus; IDA:FlyBase.
 GO:0035003; C:subapical complex; TAS:FlyBase.
 GO:0003779; F:actin binding; IDA:UniProtKB.
 GO:0005546; F:phosphatidylinositol-4,5-bisphosphate binding; IDA:FlyBase.
 GO:0030036; P:actin cytoskeleton organization; IMP:FlyBase.
 GO:0007368; P:determination of left/right symmetry; IMP:FlyBase.
 GO:0045197; P:establishment or maintenance of epithelial cell apical/basal polarity; IDA:UniProtKB.
 GO:0016336; P:establishment or maintenance of polarity of larval imaginal disc epithelium; IMP:FlyBase.
 GO:0045433; P:male courtship behavior, veined wing generated song production; IMP:FlyBase.
 GO:0042048; P:olfactory behavior; IMP:FlyBase.
 GO:0007318; P:pole plasm protein localization; TAS:FlyBase.
 GO:0032956; P:regulation of actin cytoskeleton organization; IMP:FlyBase.
 GO:0016057; P:regulation of membrane potential in photoreceptor cell; IDA:FlyBase.
 GO:0045313; P:rhabdomere membrane biogenesis; IMP:FlyBase. 
Interpro
 IPR019749; Band_41_domain.
 IPR019750; Band_41_fam.
 IPR011174; ERM.
 IPR011259; ERM_C_dom.
 IPR000798; Ez/rad/moesin_like.
 IPR014352; FERM/acyl-CoA-bd_prot_3-hlx.
 IPR019748; FERM_central.
 IPR019747; FERM_CS.
 IPR000299; FERM_domain.
 IPR018979; FERM_N.
 IPR018980; FERM_PH-like_C.
 IPR008954; Moesin.
 IPR011993; PH_like_dom. 
Pfam
 PF00769; ERM
 PF09380; FERM_C
 PF00373; FERM_M
 PF09379; FERM_N 
SMART
 SM00295; B41 
PROSITE
 PS00660; FERM_1
 PS00661; FERM_2
 PS50057; FERM_3 
PRINTS
 PR00935; BAND41.
 PR00661; ERMFAMILY.