CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-021531
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 WD repeat-containing protein 76 
Protein Synonyms/Alias
  
Gene Name
 WDR76 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
25QMKVNEYKENQNIAYubiquitination[1]
68LDQLMCPKSLSEKNSubiquitination[2]
73CPKSLSEKNSNNEVAubiquitination[1]
104KMKNTSSKAESTLQNubiquitination[3]
122AVHTESNKLQPKRTAubiquitination[1]
267EDNNERFKGFLHTWAubiquitination[1]
278HTWAGMSKPSSKNTEubiquitination[1]
286PSSKNTEKGLSSIKSubiquitination[1]
292EKGLSSIKSYKANLNubiquitination[1]
295LSSIKSYKANLNGMVubiquitination[1]
335TLVAVGAKFGQVGLCubiquitination[1]
442TPGTSYEKLTSSSMGubiquitination[1, 2, 3, 4]
450LTSSSMGKIRTVHVHubiquitination[1]
496ISLTEHTKSIASAYFubiquitination[1, 2]
531DSSCISSKIPLLTTIubiquitination[1, 2]
558FQAMWDPKQEDCVIVubiquitination[1]
582EIFHETGKRVHSFGGubiquitination[1]
624IHVFMNEKSC*****ubiquitination[1, 2]
Reference
 [1] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961]
 [2] Integrated proteomic analysis of post-translational modifications by serial enrichment.
 Mertins P, Qiao JW, Patel J, Udeshi ND, Clauser KR, Mani DR, Burgess MW, Gillette MA, Jaffe JD, Carr SA.
 Nat Methods. 2013 Jul;10(7):634-7. [PMID: 23749302]
 [3] Systematic and quantitative assessment of the ubiquitin-modified proteome.
 Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
 Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983]
 [4] Methods for quantification of in vivo changes in protein ubiquitination following proteasome and deubiquitinase inhibition.
 Udeshi ND, Mani DR, Eisenhaure T, Mertins P, Jaffe JD, Clauser KR, Hacohen N, Carr SA.
 Mol Cell Proteomics. 2012 May;11(5):148-59. [PMID: 22505724] 
Functional Description
  
Sequence Annotation
 REPEAT 311 352 WD 1.
 REPEAT 358 400 WD 2.
 REPEAT 402 441 WD 3.
 REPEAT 446 485 WD 4.
 REPEAT 493 533 WD 5.
 REPEAT 535 565 WD 6.
 REPEAT 590 626 WD 7.  
Keyword
 Complete proteome; Polymorphism; Reference proteome; Repeat; WD repeat. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 626 AA 
Protein Sequence
MSRSGAAAEK ADSRQRPQMK VNEYKENQNI AYVSLRPAQT TVLIKTAKVY LAPFSLSNYQ 60
LDQLMCPKSL SEKNSNNEVA CKKTKIKKTC RRIIPPKMKN TSSKAESTLQ NSSSAVHTES 120
NKLQPKRTAD AMNLSVDVES SQDGDSDEDT TPSLDFSGLS PYERKRLKNI SENADFFASL 180
QLSESAARLR EMIEKRQPPK SKRKKPKREN GIGCRRSMRL LKVDPSGVSL PAAPTPPTLV 240
ADETPLLPPG PLEMTSENQE DNNERFKGFL HTWAGMSKPS SKNTEKGLSS IKSYKANLNG 300
MVISEDTVYK VTTGPIFSMA LHPSETRTLV AVGAKFGQVG LCDLTQQPKE DGVYVFHPHS 360
QPVSCLYFSP ANPAHILSLS YDGTLRCGDF SRAIFEEVYR NERSSFSSFD FLAEDASTLI 420
VGHWDGNMSL VDRRTPGTSY EKLTSSSMGK IRTVHVHPVH RQYFITAGLR DTHIYDARRL 480
NSRRSQPLIS LTEHTKSIAS AYFSPLTGNR VVTTCADCNL RIFDSSCISS KIPLLTTIRH 540
NTFTGRWLTR FQAMWDPKQE DCVIVGSMAH PRRVEIFHET GKRVHSFGGE YLVSVCSINA 600
MHPTRYILAG GNSSGKIHVF MNEKSC 626 
Gene Ontology
  
Interpro
 IPR015943; WD40/YVTN_repeat-like_dom.
 IPR001680; WD40_repeat.
 IPR017986; WD40_repeat_dom. 
Pfam
 PF00400; WD40 
SMART
 SM00320; WD40 
PROSITE
 PS00678; WD_REPEATS_1
 PS50082; WD_REPEATS_2
 PS50294; WD_REPEATS_REGION 
PRINTS