CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-037335
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
  
Protein Name
 NAD(P) transhydrogenase, mitochondrial 
Protein Synonyms/Alias
  
Gene Name
 NNT 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
136AAALEQFKSLGAEPLubiquitination[1]
148EPLEVDLKESGEGQGubiquitination[1]
263LYSNNITKLLKAISPacetylation[2]
266NNITKLLKAISPDKDacetylation[3]
302TVVMKDGKVIFPAPTacetylation[2]
311IFPAPTPKNIPQGAPubiquitination[1]
940MLLGDAKKTCDALQAacetylation[4]
Reference
 [1] Landscape of the PARKIN-dependent ubiquitylome in response to mitochondrial depolarization.
 Sarraf SA, Raman M, Guarani-Pereira V, Sowa ME, Huttlin EL, Gygi SP, Harper JW.
 Nature. 2013 Apr 18;496(7445):372-6. [PMID: 23503661]
 [2] Proteomic investigations of lysine acetylation identify diverse substrates of mitochondrial deacetylase sirt3.
 Sol EM, Wagner SA, Weinert BT, Kumar A, Kim HS, Deng CX, Choudhary C.
 PLoS One. 2012;7(12):e50545. [PMID: 23236377]
 [3] Proteomic investigations reveal a role for RNA processing factor THRAP3 in the DNA damage response.
 Beli P, Lukashchuk N, Wagner SA, Weinert BT, Olsen JV, Baskcomb L, Mann M, Jackson SP, Choudhary C.
 Mol Cell. 2012 Apr 27;46(2):212-25. [PMID: 22424773]
 [4] Integrated proteomic analysis of post-translational modifications by serial enrichment.
 Mertins P, Qiao JW, Patel J, Udeshi ND, Clauser KR, Mani DR, Burgess MW, Gillette MA, Jaffe JD, Carr SA.
 Nat Methods. 2013 Jul;10(7):634-7. [PMID: 23749302] 
Functional Description
  
Sequence Annotation
  
Keyword
 Complete proteome; Reference proteome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 955 AA 
Protein Sequence
MVNPTLGVHE ADLLKTSGTL ISFIYPAQNP ELLNKLSQRK TTVLAMDQVP RVTIAQGYDA 60
LSSMANIAGY KAVVLAANHF GRFFTGQITA AGKVPPAKIL IVGGGVAGLA SAGAAKSMGA 120
IVRGFDTRAA ALEQFKSLGA EPLEVDLKES GEGQGGYAKE MSKEFIEAEM KLFAQQCKEV 180
DILISTALIP GKKAPVLFNK EMIESMKEGS VVVDLAAEAG GNFETTKPGE LYIHKGITHI 240
GYTDLPSRMA TQASTLYSNN ITKLLKAISP DKDNFYFDVK DDFDFGTMGH VIRGTVVMKD 300
GKVIFPAPTP KNIPQGAPVK QKTVAELEAE KAATITPFRK TMSTASAYTA GLTGILGLGI 360
AAPNLAFSQM VTTFGLAGIV GYHTVWGVTP ALHSPLMSVT NAISGLTAVG GLALMGGHLY 420
PSTTSQGLAA LAAFISSVNI AGGFLVTQRM LDMFKRPTDP PEYNYLYLLP AGTFVGGYLA 480
ALYSGYNIEQ IMYLGSGLCC VGALAGLSTQ GTARLGNALG MIGVAGGLAA TLGVLKPGPE 540
LLAQMSGAMA LGGTIGLTIA KRIQISDLPQ LVAAFHSLVG LAAVLTCIAE YIIEYPHFAT 600
DAAANLTKIV AYLGTYIGGV TFSGSLIAYG KLQGLLKSAP LLLPGRHLLN AGLLAASVGG 660
IIPFMVDPSF TTGITCLGSV SALSAVMGVT LTAAIGGADM PVVITVLNSY SGWALCAEGF 720
LLNNNLLTIV GALIGSSGAI LSYIMCVAMN RSLANVILGG YGTTSTAGGK PMEISGTHTE 780
INLDNAIDMI REANSIIITP GYGLCAAKAQ YPIADLVKML TEQGKKVRFG IHPVAGRMPG 840
QLNVLLAEAG VPYDIVLEMD EINHDFPDTD LVLVIGANDT VNSAAQEDPN SIIAGMPVLE 900
VWKSKQVIVM KRSLGVGYAA VDNPIFYKPN TAMLLGDAKK TCDALQAKVR ESYQK 955 
Gene Ontology
 GO:0016021; C:integral to membrane; IEA:InterPro.
 GO:0005743; C:mitochondrial inner membrane; IEA:Compara.
 GO:0008750; F:NAD(P)+ transhydrogenase (AB-specific) activity; IEA:InterPro.
 GO:0050661; F:NADP binding; IEA:InterPro.
 GO:0015992; P:proton transport; IEA:InterPro. 
Interpro
 IPR008143; Ala_DH/PNT_CS2.
 IPR007886; AlaDH/PNT_N.
 IPR007698; AlaDH/PNT_NAD(H)-bd.
 IPR016040; NAD(P)-bd_dom.
 IPR012136; NADH_DH_b.
 IPR026255; NADP_transhyd_a.
 IPR024605; NADP_transhyd_a_C. 
Pfam
 PF01262; AlaDh_PNT_C
 PF05222; AlaDh_PNT_N
 PF12769; DUF3814
 PF02233; PNTB 
SMART
 SM01002; AlaDh_PNT_C 
PROSITE
 PS00837; ALADH_PNT_2 
PRINTS