CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-018737
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Transmembrane protein 131 
Protein Synonyms/Alias
 Protein RW1 
Gene Name
 TMEM131 
Gene Synonyms/Alias
 KIAA0257; RW1 
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
96GLSSYQQKSISLYRGubiquitination[1, 2, 3]
704NSFSQKVKIQQIRSLubiquitination[2]
761VGLPFLSKSEPKVQPubiquitination[2]
889VSRFNLSKVAKIDLRubiquitination[2]
892FNLSKVAKIDLRTLEubiquitination[2]
982ENLRVAGKLPGPGSSubiquitination[1, 2, 3]
993PGSSLRFKITEALLKubiquitination[2]
1000KITEALLKDCTDSLKubiquitination[2]
1016REPNFTLKRTFKVENubiquitination[1, 2, 3]
Reference
 [1] Systematic and quantitative assessment of the ubiquitin-modified proteome.
 Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
 Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983]
 [2] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961]
 [3] Landscape of the PARKIN-dependent ubiquitylome in response to mitochondrial depolarization.
 Sarraf SA, Raman M, Guarani-Pereira V, Sowa ME, Huttlin EL, Gygi SP, Harper JW.
 Nature. 2013 Apr 18;496(7445):372-6. [PMID: 23503661] 
Functional Description
 May play a role in the immune response to viral infection (By similarity). 
Sequence Annotation
 MOD_RES 803 803 Phosphoserine.
 MOD_RES 1375 1375 Phosphoserine.
 MOD_RES 1621 1621 Phosphoserine (By similarity).
 MOD_RES 1863 1863 Phosphoserine.
 CARBOHYD 300 300 N-linked (GlcNAc...).  
Keyword
 Complete proteome; Glycoprotein; Membrane; Phosphoprotein; Reference proteome; Transmembrane; Transmembrane helix. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 1883 AA 
Protein Sequence
MGKRAGGGAT GATTAAVSTS AGAGLEPAAA RSGGPRSAAA GLLGALHLVM TLVVAAARAE 60
KEAFVQSESI IEVLRFDDGG LLQTETTLGL SSYQQKSISL YRGNCRPIRF EPPMLDFHEQ 120
PVGMPKMEKV YLHNPSSEET ITLVSISATT SHFHASFFQN RKILPGGNTS FDVVFLARVV 180
GNVENTLFIN TSNHGVFTYQ VFGVGVPNPY RLRPFLGARV PVNSSFSPII NIHNPHSEPL 240
QVVEMYSSGG DLHLELPTGQ QGGTRKLWEI PPYETKGVMR ASFSSREADN HTAFIRIKTN 300
ASDSTEFIIL PVEVEVTTAP GIYSSTEMLD FGTLRTQDLP KVLNLHLLNS GTKDVPITSV 360
RPTPQNDAIT VHFKPITLKA SESKYTKVAS ISFDASKAKK PSQFSGKITV KAKEKSYSKL 420
EIPYQAEVLD GYLGFDHAAT LFHIRDSPAD PVERPIYLTN TFSFAILIHD VLLPEEAKTM 480
FKVHNFSKPV LILPNESGYI FTLLFMPSTS SMHIDNNILL ITNASKFHLP VRVYTGFLDY 540
FVLPPKIEER FIDFGVLSAT EASNILFAII NSNPIELAIK SWHIIGDGLS IELVAVERGN 600
RTTIISSLPE FEKSSLSDQS SVTLASGYFA VFRVKLTAKK LEGIHDGAIQ ITTDYEILTI 660
PVKAVIAVGS LTCFPKHVVL PPSFPGKIVH QSLNIMNSFS QKVKIQQIRS LSEDVRFYYK 720
RLRGNKEDLE PGKKSKIANI YFDPGLQCGD HCYVGLPFLS KSEPKVQPGV AMQEDMWDAD 780
WDLHQSLFKG WTGIKENSGH RLSAIFEVNT DLQKNIISKI TAELSWPSIL SSPRHLKFPL 840
TNTNCSSEEE ITLENPADVP VYVQFIPLAL YSNPSVFVDK LVSRFNLSKV AKIDLRTLEF 900
QVFRNSAHPL QSSTGFMEGL SRHLILNLIL KPGEKKSVKV KFTPVHNRTV SSLIIVRNNL 960
TVMDAVMVQG QGTTENLRVA GKLPGPGSSL RFKITEALLK DCTDSLKLRE PNFTLKRTFK 1020
VENTGQLQIH IETIEISGYS CEGYGFKVVN CQEFTLSANA SRDIIILFTP DFTASRVIRE 1080
LKFITTSGSE FVFILNASLP YHMLATCAEA LPRPNWELAL YIIISGIMSA LFLLVIGTAY 1140
LEAQGIWEPF RRRLSFEASN PPFDVGRPFD LRRIVGISSE GNLNTLSCDP GHSRGFCGAG 1200
GSSSRPSAGS HKQCGPSVHP HSSHSNRNSA DVENVRAKNS SSTSSRTSAQ AASSQSANKT 1260
SPLVLDSNTV TQGHTAGRKS KGAKQSQHGS QHHAHSPLEQ HPQPPLPPPV PQPQEPQPER 1320
LSPAPLAHPS HPERASSARH SSEDSDITSL IEAMDKDFDH HDSPALEVFT EQPPSPLPKS 1380
KGKGKPLQRK VKPPKKQEEK EKKGKGKPQE DELKDSLADD DSSSTTTETS NPDTEPLLKE 1440
DTEKQKGKQA MPEKHESEMS QVKQKSKKLL NIKKEIPTDV KPSSLELPYT PPLESKQRRN 1500
LPSKIPLPTA MTSGSKSRNA QKTKGTSKLV DNRPPALAKF LPNSQELGNT SSSEGEKDSP 1560
PPEWDSVPVH KPGSSTDSLY KLSLQTLNAD IFLKQRQTSP TPASPSPPAA PCPFVARGSY 1620
SSIVNSSSSS DPKIKQPNGS KHKLTKAASL PGKNGNPTFA AVTAGYDKSP GGNGFAKVSS 1680
NKTGFSSSLG ISHAPVDSDG SDSSGLWSPV SNPSSPDFTP LNSFSAFGNS FNLTGEVFSK 1740
LGLSRSCNQA SQRSWNEFNS GPSYLWESPA TDPSPSWPAS SGSPTHTATS VLGNTSGLWS 1800
TTPFSSSIWS SNLSSALPFT TPANTLASIG LMGTENSPAP HAPSTSSPAD DLGQTYNPWR 1860
IWSPTIGRRS SDPWSNSHFP HEN 1883 
Gene Ontology
 GO:0016021; C:integral to membrane; IEA:UniProtKB-KW. 
Interpro
 IPR022113; DUF3651_TMEM131.
 IPR008962; PapD-like. 
Pfam
 PF12371; DUF3651 
SMART
  
PROSITE
  
PRINTS