UniProt Accession

 1433Z_MOUSE; P63101; P35215; P70197; P97286; Q3TSF1; Q5EBQ1 

Genbank Protein ID

 D78647; D87660; U79231; D83037; AK083368; AK145657; AK146800; AK150381; AK151900; AK162099; AK167128; BC050891; BC089334 

Genbank Nucleotide ID

 BAA11464.1; BAA13421.1; AAC53254.1; BAA11751.1; BAC38887.1; BAE26570.1; BAE27442.1; BAE29512.1; BAE30783.1; BAE36724.1; BAE39275.1; AAH50891.1; AAH89334.1 

Protein Name

 14-3-3 protein zeta/delta 

Protein Synonyms/Alias

 Protein kinase C inhibitor protein 1; KCIP-1; SEZ-2 

Gene Name

 Ywhaz 

Gene Synonyms/Alias

  

Created Date

 July 27, 2013 

Organism

 Mus musculus (Mouse) 

NCBI Taxa ID

 10090 

Lysine Modification

Position	Peptide	Type	References
9	DKNELVQKAKLAEQA	ubiquitination	[1]
11	NELVQKAKLAEQAER	ubiquitination	[1, 2]
49	NLLSVAYKNVVGARR	ubiquitination	[1]
68	VVSSIEQKTEGAEKK	ubiquitination	[1]
74	QKTEGAEKKQQMARE	ubiquitination	[1]
85	MAREYREKIETELRD	ubiquitination	[1]
115	NASQPESKVFYLKMK	acetylation	[3, 4]
115	NASQPESKVFYLKMK	ubiquitination	[1]
120	ESKVFYLKMKGDYYR	ubiquitination	[1]
122	KVFYLKMKGDYYRYL	ubiquitination	[1]
138	EVAAGDDKKGIVDQS	ubiquitination	[1, 2]
139	VAAGDDKKGIVDQSQ	ubiquitination	[1]
157	QEAFEISKKEMQPTH	acetylation	[3, 4]
157	QEAFEISKKEMQPTH	ubiquitination	[1]
158	EAFEISKKEMQPTHP	ubiquitination	[1]

Reference

 [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023]
 [2] BTB-ZF factors recruit the E3 ligase cullin 3 to regulate lymphoid effector programs.
 Mathew R, Seiler MP, Scanlon ST, Mao AP, Constantinides MG, Bertozzi-Villa C, Singer JD, Bendelac A.
 Nature. 2012 Nov 22;491(7425):618-21. [PMID: 23086144]
 [3] Quantitative acetylome analysis reveals the roles of SIRT1 in regulating diverse substrates and cellular pathways.
 Chen Y, Zhao W, Yang JS, Cheng Z, Luo H, Lu Z, Tan M, Gu W, Zhao Y.
 Mol Cell Proteomics. 2012 Oct;11(10):1048-62. [PMID: 22826441]
 [4] Proteomic investigations of lysine acetylation identify diverse substrates of mitochondrial deacetylase sirt3.
 Sol EM, Wagner SA, Weinert BT, Kumar A, Kim HS, Deng CX, Choudhary C.
 PLoS One. 2012;7(12):e50545. [PMID: 23236377] 

Functional Description

 Adapter protein implicated in the regulation of a large spectrum of both general and specialized signaling pathways. Binds to a large number of partners, usually by recognition of a phosphoserine or phosphothreonine motif. Binding generally results in the modulation of the activity of the binding partner. 

Sequence Annotation

 MOD_RES 1 1 N-acetylmethionine (By similarity).
 MOD_RES 3 3 N6-acetyllysine (By similarity).
 MOD_RES 58 58 Phosphoserine; by PKA.
 MOD_RES 68 68 N6-acetyllysine (By similarity).
 MOD_RES 184 184 Phosphoserine (By similarity).
 MOD_RES 207 207 Phosphoserine (By similarity).
 MOD_RES 232 232 Phosphothreonine; by CK1 (By similarity).  

Keyword

 Acetylation; Complete proteome; Cytoplasm; Direct protein sequencing; Phosphoprotein; Reference proteome. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 245 AA 

Protein Sequence

Gene Ontology

 GO:0031252; C:cell leading edge; IEA:Compara.
 GO:0030659; C:cytoplasmic vesicle membrane; TAS:Reactome.
 GO:0005829; C:cytosol; TAS:Reactome.
 GO:0042470; C:melanosome; IEA:UniProtKB-SubCell.
 GO:0005739; C:mitochondrion; IDA:MGI.
 GO:0005634; C:nucleus; IDA:MGI.
 GO:0048471; C:perinuclear region of cytoplasm; IEA:Compara.
 GO:0014069; C:postsynaptic density; IEA:Compara.
 GO:0043234; C:protein complex; IEA:Compara.
 GO:0019904; F:protein domain specific binding; IDA:UniProtKB.
 GO:0002553; P:histamine secretion by mast cell; IEA:Compara.
 GO:0006605; P:protein targeting; IDA:MGI.
 GO:0006626; P:protein targeting to mitochondrion; IEA:Compara.
 GO:0010941; P:regulation of cell death; IGI:MGI. 

Interpro

 IPR000308; 14-3-3.
 IPR023409; 14-3-3_CS.
 IPR023410; 14-3-3_domain. 

Pfam

 PF00244; 14-3-3 

SMART

 SM00101; 14_3_3 

PROSITE

 PS00796; 1433_1
 PS00797; 1433_2 

PRINTS

 PR00305; 1433ZETA.