UniProt Accession

 CBR4_HUMAN; Q8N4T8; Q8WTW8; Q96K93 

Genbank Protein ID

 AK027337; AK291756; AL833393; AC021151; CH471056; BC021973; BC033650 

Genbank Nucleotide ID

 BAB55045.1; BAF84445.1; CAH10582.1; EAX04797.1; AAH21973.1; AAH33650.1 

Protein Name

 Carbonyl reductase family member 4 

Protein Synonyms/Alias

 3-oxoacyl-[acyl-carrier-protein] reductase; Quinone reductase CBR4 

Gene Name

 CBR4 

Gene Synonyms/Alias

  

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
96	DGLLVRTKTEDMVSQ	ubiquitination	[1]
140	VGSIVGLKGNSGQSV	ubiquitination	[1]
152	QSVYSASKGGLVGFS	ubiquitination	[1]
187	FVHTDMTKDLKEEHL	ubiquitination	[1]

Reference

 [1] A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles.
 Wagner SA, Beli P, Weinert BT, Nielsen ML, Cox J, Mann M, Choudhary C.
 Mol Cell Proteomics. 2011 Oct;10(10):M111.013284. [PMID: 21890473] 

Functional Description

 The heteroteramer with HSD17B8 has NADH-dependent 3- ketoacyl-acyl carrier protein reductase activity. May play a role in biosynthesis of fatty acids in mitochondria. The homotetramer may act as NADPH-dependent quinone reductase. Has broad substrate specificity and reduces 9,10-phenanthrenequinone, 1,4-benzoquinone and various other o-quinones and p-quinones (in vitro). 

Sequence Annotation

 NP_BIND 7 31 NAD or NADP (By similarity).
 ACT_SITE 148 148 Proton acceptor (By similarity).
 BINDING 135 135 Substrate (By similarity).  

Keyword

 Alternative splicing; Complete proteome; Fatty acid biosynthesis; Fatty acid metabolism; Lipid biosynthesis; Lipid metabolism; Mitochondrion; NAD; NADP; Oxidoreductase; Polymorphism; Reference proteome. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 237 AA 

Protein Sequence

Gene Ontology

 GO:0005759; C:mitochondrial matrix; IDA:UniProtKB.
 GO:0003955; F:NAD(P)H dehydrogenase (quinone) activity; IDA:UniProtKB.
 GO:0070402; F:NADPH binding; IDA:UniProtKB.
 GO:0008753; F:NADPH dehydrogenase (quinone) activity; IDA:UniProtKB.
 GO:0048038; F:quinone binding; IDA:UniProtKB.
 GO:0044597; P:daunorubicin metabolic process; IMP:UniProtKB.
 GO:0044598; P:doxorubicin metabolic process; IMP:UniProtKB.
 GO:0006633; P:fatty acid biosynthetic process; IEA:UniProtKB-UniPathway.
 GO:0051289; P:protein homotetramerization; IPI:UniProtKB. 

Interpro

 IPR002198; DH_sc/Rdtase_SDR.
 IPR002347; Glc/ribitol_DH.
 IPR016040; NAD(P)-bd_dom.
 IPR020904; Sc_DH/Rdtase_CS. 

Pfam

 PF00106; adh_short 

SMART

  

PROSITE

 PS00061; ADH_SHORT 

PRINTS

 PR00081; GDHRDH.
 PR00080; SDRFAMILY.