| Tag | Content |
|---|
| CPLM ID | CPLM-010487 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | Zinc finger protein Helios |
Protein Synonyms/Alias | Ikaros family zinc finger protein 2 |
Gene Name | Ikzf2 |
Gene Synonyms/Alias | Helios; Zfpn1a2; Znfn1a2 |
Created Date | July 27, 2013 |
Organism | Mus musculus (Mouse) |
NCBI Taxa ID | 10090 |
Lysine Modification | Position | Peptide | Type | References |
|---|
| 288 | PQKFVGEKLMRFSYP | acetylation | [1] |
|
Reference | [1] Proteomic analysis of lysine acetylation sites in rat tissues reveals organ specificity and subcellular patterns. Lundby A, Lage K, Weinert BT, Bekker-Jensen DB, Secher A, Skovgaard T, Kelstrup CD, Dmytriyev A, Choudhary C, Lundby C, Olsen JV. Cell Rep. 2012 Aug 30;2(2):419-31. [ PMID: 22902405] |
Functional Description | Associates with Ikaros at centromeric heterochromatin. |
Sequence Annotation | ZN_FING 112 134 C2H2-type 1.
ZN_FING 140 162 C2H2-type 2.
ZN_FING 168 190 C2H2-type 3.
ZN_FING 196 219 C2H2-type 4.
ZN_FING 471 493 C2H2-type 5.
ZN_FING 499 523 C2H2-type 6.
MOD_RES 56 56 Phosphoserine (By similarity).
MOD_RES 78 78 Phosphoserine (By similarity).
MOD_RES 79 79 Phosphoserine (By similarity).
MOD_RES 288 288 N6-acetyllysine (By similarity). |
Keyword | Acetylation; Activator; Alternative splicing; Complete proteome; Direct protein sequencing; DNA-binding; Metal-binding; Nucleus; Phosphoprotein; Reference proteome; Repeat; Transcription; Transcription regulation; Zinc; Zinc-finger. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 526 AA |
Protein Sequence | METDAIDGYI TCDNELSPEG EHANMAIDLT SSTPNGQHAS PSHMTSTNSV KLEMQSDEEC 60
DRQPLSREDE IRGHDEGSSL EEPLIESSEV ADNRKVQDLQ GEGGIRLPNG KLKCDVCGMV 120
CIGPNVLMVH KRSHTGERPF HCNQCGASFT QKGNLLRHIK LHSGEKPFKC PFCSYACRRR 180
DALTGHLRTH SVGKPHKCNY CGRSYKQRSS LEEHKERCHN YLQNVSMEAA GQVMSHHVPP 240
MEDCKEQEPI MDNNISLVPF ERPAVIEKLT ANMGKRKSST PQKFVGEKLM RFSYPDIHFD 300
MNLTYEKEAE LMQSHMMDQA INNAITYLGA EALHPLMQHA PSTIAEVAPV ISSAYSQVYH 360
PNRIERPISR ETSDSHENNM DGPISLIRPK SRPQEREASP SNSCLDSTDS ESSHDDRQSY 420
QGNPALNPKR KQSPAYMKED VKALDATKAP KGSLKDIYKV FNGEGEQIRA FKCEHCRVLF 480
LDHVMYTIHM GCHGYRDPLE CNICGYRSQD RYEFSSHIVR GEHTFH 526 |
Gene Ontology | GO:0005634; C:nucleus; IDA:MGI. GO:0003677; F:DNA binding; IEA:UniProtKB-KW. GO:0008270; F:zinc ion binding; IEA:InterPro. GO:0045944; P:positive regulation of transcription from RNA polymerase II promoter; IDA:MGI. GO:0006351; P:transcription, DNA-dependent; IEA:UniProtKB-KW. |
Interpro | |
Pfam | |
SMART | |
PROSITE | |
PRINTS | |