CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-017695
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 AT-rich interactive domain-containing protein 1B 
Protein Synonyms/Alias
 ARID domain-containing protein 1B; BRG1-associated factor 250b; BAF250B; BRG1-binding protein hELD/OSA1; Osa homolog 2; hOsa2; p250R 
Gene Name
 ARID1B 
Gene Synonyms/Alias
 BAF250B; DAN15; KIAA1235; OSA2 
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
1566SPFLPSMKMQKVMPTacetylation[1]
1777KFDKLPIKIVKKNNLacetylation[1]
2097PPFSRQEKFYATLVRubiquitination[2]
2187DMMCRAAKALLAMARubiquitination[2]
Reference
 [1] Lysine acetylation targets protein complexes and co-regulates major cellular functions.
 Choudhary C, Kumar C, Gnad F, Nielsen ML, Rehman M, Walther TC, Olsen JV, Mann M.
 Science. 2009 Aug 14;325(5942):834-40. [PMID: 19608861]
 [2] A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles.
 Wagner SA, Beli P, Weinert BT, Nielsen ML, Cox J, Mann M, Choudhary C.
 Mol Cell Proteomics. 2011 Oct;10(10):M111.013284. [PMID: 21890473] 
Functional Description
 Involved in transcriptional activation and repression of select genes by chromatin remodeling (alteration of DNA-nucleosome topology). Belongs to the neural progenitors-specific chromatin remodeling complex (npBAF complex) and the neuron-specific chromatin remodeling complex (nBAF complex). During neural development a switch from a stem/progenitor to a post-mitotic chromatin remodeling mechanism occurs as neurons exit the cell cycle and become committed to their adult state. The transition from proliferating neural stem/progenitor cells to post-mitotic neurons requires a switch in subunit composition of the npBAF and nBAF complexes. As neural progenitors exit mitosis and differentiate into neurons, npBAF complexes which contain ACTL6A/BAF53A and PHF10/BAF45A, are exchanged for homologous alternative ACTL6B/BAF53B and DPF1/BAF45B or DPF3/BAF45C subunits in neuron-specific complexes (nBAF). The npBAF complex is essential for the self-renewal/proliferative capacity of the multipotent neural stem cells. The nBAF complex along with CREST plays a role regulating the activity of genes essential for dendrite growth (By similarity). Binds DNA non-specifically. 
Sequence Annotation
 DOMAIN 1053 1144 ARID.
 MOTIF 419 423 LXXLL.
 MOTIF 2036 2040 LXXLL.
 MOD_RES 2 2 N-acetylalanine.
 MOD_RES 516 516 Phosphoserine.
 MOD_RES 1555 1555 Phosphoserine.
 MOD_RES 1559 1559 Phosphoserine.
 MOD_RES 1715 1715 Phosphoserine.
 MOD_RES 1777 1777 N6-acetyllysine.  
Keyword
 3D-structure; Acetylation; Alternative splicing; Chromatin regulator; Complete proteome; DNA-binding; Mental retardation; Neurogenesis; Nucleus; Phosphoprotein; Polymorphism; Reference proteome; Transcription; Transcription regulation; Triplet repeat expansion. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 2236 AA 
Protein Sequence
MAHNAGAAAA AGTHSAKSGG SEAALKEGGS AAALSSSSSS SAAAAAASSS SSSGPGSAME 60
TGLLPNHKLK TVGEAPAAPP HQQHHHHHHA HHHHHHAHHL HHHHALQQQL NQFQQQQQQQ 120
QQQQQQQQQQ QHPISNNNSL GGAGGGAPQP GPDMEQPQHG GAKDSAAGGQ ADPPGPPLLS 180
KPGDEDDAPP KMGEPAGGRY EHPGLGALGT QQPPVAVPGG GGGPAAVPEF NNYYGSAAPA 240
SGGPGGRAGP CFDQHGGQQS PGMGMMHSAS AAAAGAPGSM DPLQNSHEGY PNSQCNHYPG 300
YSRPGAGGGG GGGGGGGGGS GGGGGGGGAG AGGAGAGAVA AAAAAAAAAA GGGGGGGYGG 360
SSAGYGVLSS PRQQGGGMMM GPGGGGAASL SKAAAGSAAG GFQRFAGQNQ HPSGATPTLN 420
QLLTSPSPMM RSYGGSYPEY SSPSAPPPPP SQPQSQAAAA GAAAGGQQAA AGMGLGKDMG 480
AQYAAASPAW AAAQQRSHPA MSPGTPGPTM GRSQGSPMDP MVMKRPQLYG MGSNPHSQPQ 540
QSSPYPGGSY GPPGPQRYPI GIQGRTPGAM AGMQYPQQQM PPQYGQQGVS GYCQQGQQPY 600
YSQQPQPPHL PPQAQYLPSQ SQQRYQPQQD MSQEGYGTRS QPPLAPGKPN HEDLNLIQQE 660
RPSSLPDLSG SIDDLPTGTE ATLSSAVSAS GSTSSQGDQS NPAQSPFSPH ASPHLSSIPG 720
GPSPSPVGSP VGSNQSRSGP ISPASIPGSQ MPPQPPGSQS ESSSHPALSQ SPMPQERGFM 780
AGTQRNPQMA QYGPQQTGPS MSPHPSPGGQ MHAGISSFQQ SNSSGTYGPQ MSQYGPQGNY 840
SRPPAYSGVP SASYSGPGPG MGISANNQMH GQGPSQPCGA VPLGRMPSAG MQNRPFPGNM 900
SSMTPSSPGM SQQGGPGMGP PMPTVNRKAQ EAAAAVMQAA ANSAQSRQGS FPGMNQSGLM 960
ASSSPYSQPM NNSSSLMNTQ APPYSMAPAM VNSSAASVGL ADMMSPGESK LPLPLKADGK 1020
EEGTPQPESK SKKSSSSTTT GEKITKVYEL GNEPERKLWV DRYLTFMEER GSPVSSLPAV 1080
GKKPLDLFRL YVCVKEIGGL AQVNKNKKWR ELATNLNVGT SSSAASSLKK QYIQYLFAFE 1140
CKIERGEEPP PEVFSTGDTK KQPKLQPPSP ANSGSLQGPQ TPQSTGSNSM AEVPGDLKPP 1200
TPASTPHGQM TPMQGGRSST ISVHDPFSDV SDSSFPKRNS MTPNAPYQQG MSMPDVMGRM 1260
PYEPNKDPFG GMRKVPGSSE PFMTQGQMPN SSMQDMYNQS PSGAMSNLGM GQRQQFPYGA 1320
SYDRRHEPYG QQYPGQGPPS GQPPYGGHQP GLYPQQPNYK RHMDGMYGPP AKRHEGDMYN 1380
MQYSSQQQEM YNQYGGSYSG PDRRPIQGQY PYPYSRERMQ GPGQIQTHGI PPQMMGGPLQ 1440
SSSSEGPQQN MWAARNDMPY PYQNRQGPGG PTQAPPYPGM NRTDDMMVPD QRINHESQWP 1500
SHVSQRQPYM SSSASMQPIT RPPQPSYQTP PSLPNHISRA PSPASFQRSL ENRMSPSKSP 1560
FLPSMKMQKV MPTVPTSQVT GPPPQPPPIR REITFPPGSV EASQPVLKQR RKITSKDIVT 1620
PEAWRVMMSL KSGLLAESTW ALDTINILLY DDSTVATFNL SQLSGFLELL VEYFRKCLID 1680
IFGILMEYEV GDPSQKALDH NAARKDDSQS LADDSGKEEE DAECIDDDEE DEEDEEEDSE 1740
KTESDEKSSI ALTAPDAAAD PKEKPKQASK FDKLPIKIVK KNNLFVVDRS DKLGRVQEFN 1800
SGLLHWQLGG GDTTEHIQTH FESKMEIPPR RRPPPPLSSA GRKKEQEGKG DSEEQQEKSI 1860
IATIDDVLSA RPGALPEDAN PGPQTESSKF PFGIQQAKSH RNIKLLEDEP RSRDETPLCT 1920
IAHWQDSLAK RCICVSNIVR SLSFVPGNDA EMSKHPGLVL ILGKLILLHH EHPERKRAPQ 1980
TYEKEEDEDK GVACSKDEWW WDCLEVLRDN TLVTLANISG QLDLSAYTES ICLPILDGLL 2040
HWMVCPSAEA QDPFPTVGPN SVLSPQRLVL ETLCKLSIQD NNVDLILATP PFSRQEKFYA 2100
TLVRYVGDRK NPVCREMSMA LLSNLAQGDA LAARAIAVQK GSIGNLISFL EDGVTMAQYQ 2160
QSQHNLMHMQ PPPLEPPSVD MMCRAAKALL AMARVDENRS EFLLHEGRLL DISISAVLNS 2220
LVASVICDVL FQIGQL 2236 
Gene Ontology
 GO:0016514; C:SWI/SNF complex; IDA:UniProtKB.
 GO:0003677; F:DNA binding; IDA:GDB.
 GO:0003713; F:transcription coactivator activity; NAS:UniProtKB.
 GO:0048096; P:chromatin-mediated maintenance of transcription; NAS:UniProtKB.
 GO:0007399; P:nervous system development; IEA:UniProtKB-KW.
 GO:0006351; P:transcription, DNA-dependent; IEA:UniProtKB-KW. 
Interpro
 IPR001606; ARID/BRIGHT_DNA-bd.
 IPR011989; ARM-like.
 IPR021906; DUF3518. 
Pfam
 PF01388; ARID
 PF12031; DUF3518 
SMART
 SM00501; BRIGHT 
PROSITE
 PS51011; ARID 
PRINTS