| Tag | Content |
|---|
| CPLM ID | CPLM-021118 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | Muscarinic acetylcholine receptor M2 |
Protein Synonyms/Alias | |
Gene Name | Chrm2 |
Gene Synonyms/Alias | Chrm-2 |
Created Date | July 27, 2013 |
Organism | Mus musculus (Mouse) |
NCBI Taxa ID | 10090 |
Lysine Modification | Position | Peptide | Type | References |
|---|
| 222 | SRIKKEKKEPVANQD | ubiquitination | [1] |
|
Reference | [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues. Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C. Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [ PMID: 22790023] |
Functional Description | The muscarinic acetylcholine receptor mediates various cellular responses, including inhibition of adenylate cyclase, breakdown of phosphoinositides and modulation of potassium channels through the action of G proteins. Primary transducing effect is adenylate cyclase inhibition. |
Sequence Annotation | MOD_RES 232 232 Phosphoserine.
MOD_RES 234 234 Phosphoserine.
MOD_RES 446 446 Phosphothreonine (Potential).
MOD_RES 450 450 Phosphothreonine (Potential).
MOD_RES 465 465 Phosphothreonine (Potential).
CARBOHYD 2 2 N-linked (GlcNAc...) (Potential).
CARBOHYD 3 3 N-linked (GlcNAc...) (Potential).
CARBOHYD 6 6 N-linked (GlcNAc...) (Potential).
DISULFID 96 176 By similarity. |
Keyword | Cell junction; Cell membrane; Complete proteome; Disulfide bond; G-protein coupled receptor; Glycoprotein; Membrane; Phosphoprotein; Postsynaptic cell membrane; Receptor; Reference proteome; Synapse; Transducer; Transmembrane; Transmembrane helix. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 466 AA |
Protein Sequence | MNNSTNSSNN GLAITSPYKT FEVVFIVLVA GSLSLVTIIG NILVMVSIKV NRHLQTVNNY 60
FLFSLACADL IIGVFSMNLY TLYTVIGYWP LGPVVCDLWL ALDYVVSNAS VMNLLIISFD 120
RYFCVTKPLT YPVKRTTKMA GMMIAAAWVL SFILWAPAIL FWQFIVGVRT VEDGECYIQF 180
FSNAAVTFGT AIAAFYLPVI IMTVLYWHIS RASKSRIKKE KKEPVANQDP VSPSLVQGRI 240
VKPNNNNMPG GDGGLEHNKI QNGKAPRDGG TENCVQGEEK ESSNDSTSVS AVASNMRDDE 300
ITQDENTVST SLGHSKDDNS RQTCIKIVTK TQKGDACTPT STTVELVGSS GQNGDEKQNI 360
VARKIVKMTK QPAKKKPPPS REKKVTRTIL AILLAFIITW APYNVMVLIN TFCAPCIPNT 420
VWTIGYWLCY INSTINPACY ALCNATFKKT FKHLLMCHYK NIGATR 466 |
Gene Ontology | GO:0030054; C:cell junction; IEA:UniProtKB-KW. GO:0005887; C:integral to plasma membrane; IEA:InterPro. GO:0045211; C:postsynaptic membrane; IEA:UniProtKB-SubCell. GO:0016907; F:G-protein coupled acetylcholine receptor activity; IMP:MGI. GO:0030815; P:negative regulation of cAMP metabolic process; IEA:InterPro. GO:0008016; P:regulation of heart contraction; IEA:InterPro. GO:0043269; P:regulation of ion transport; IEA:InterPro. GO:0009615; P:response to virus; IEA:Compara. |
Interpro | |
Pfam | |
SMART | |
PROSITE | |
PRINTS | |