| Tag | Content |
|---|
| CPLM ID | CPLM-005623 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | UDP-N-acetyl-D-mannosamine dehydrogenase |
Protein Synonyms/Alias | UDP-ManNAc 6-dehydrogenase |
Gene Name | wecC |
Gene Synonyms/Alias | rffD; b3787; JW5599 |
Created Date | July 27, 2013 |
Organism | Escherichia coli (strain K12) |
NCBI Taxa ID | 83333 |
Lysine Modification | Position | Peptide | Type | References |
|---|
| 172 | QVMVELIKNDRVIGG | acetylation | [1] | | 212 | SRTAEMCKLTENSFR | acetylation | [1] | | 295 | AREVNDHKPFWVIDQ | acetylation | [1] | | 331 | ACFGLAFKPNIDDLR | acetylation | [1] |
|
Reference | [1] Acetyl-Phosphate Is a Critical Determinant of Lysine Acetylation in E. coli. Weinert BT, Iesmantavicius V, Wagner SA, Schölz C, Gummesson B, Beli P, Nyström T, Choudhary C. Mol Cell. 2013 Jul 25;51(2):265-72. [ PMID: 23830618] |
Functional Description | Catalyzes the four-electron oxidation of UDP-N-acetyl-D- mannosamine (UDP-ManNAc), reducing NAD(+) and releasing UDP-N- acetylmannosaminuronic acid (UDP-ManNAcA). |
Sequence Annotation | NP_BIND 5 22 NAD (Potential).
ACT_SITE 266 266 By similarity. |
Keyword | Complete proteome; NAD; Oxidoreductase; Reference proteome. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 420 AA |
Protein Sequence | MSFATISVIG LGYIGLPTAA AFASRQKQVI GVDINQHAVD TINRGEIHIV EPDLASVVKT 60
AVEGGFLRAS TTPVEADAWL IAVPTPFKGD HEPDMTYVES AARSIAPVLK KGALVILEST 120
SPVGSTEKMA EWLAEMRPDL TFPQQVGEQA DVNIAYCPER VLPGQVMVEL IKNDRVIGGM 180
TPVCSARASE LYKIFLEGEC VVTNSRTAEM CKLTENSFRD VNIAFANELS LICADQGINV 240
WELIRLANRH PRVNILQPGP GVGGHCIAVD PWFIVAQNPQ QARLIRTARE VNDHKPFWVI 300
DQVKAAVADC LAATDKRASE LKIACFGLAF KPNIDDLRES PAMEIAELIA QWHSGETLVV 360
EPNIHQLPKK LTGLCTLAQL DEALATADVL VMLVDHSQFK VINGDNVHQQ YVVDAKGVWR 420 |
Gene Ontology | GO:0051287; F:NAD binding; IEA:InterPro. GO:0016616; F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor; IEA:InterPro. GO:0009246; P:enterobacterial common antigen biosynthetic process; IEA:UniProtKB-UniPathway. |
Interpro | |
Pfam | |
SMART | |
PROSITE | |
PRINTS | |