UniProt Accession

 1433B_MOUSE; Q9CQV8; O70455; Q3TY33; Q3UAN6 

Genbank Protein ID

 AF058797; AK002632; AK004872; AK011389; AK083367; AK144061; AK150414; AK151294; AK158932 

Genbank Nucleotide ID

 AAC14343.1; BAB22246.1; BAB23631.1; BAB27587.1; BAC38886.1; BAE25678.1; BAE29538.1; BAE30278.1; BAE34730.1 

Protein Name

 14-3-3 protein beta/alpha 

Protein Synonyms/Alias

 Protein kinase C inhibitor protein 1; KCIP-1; 14-3-3 protein beta/alpha, N-terminally processed 

Gene Name

 Ywhab 

Gene Synonyms/Alias

  

Created Date

 July 27, 2013 

Organism

 Mus musculus (Mouse) 

NCBI Taxa ID

 10090 

Lysine Modification

Position	Peptide	Type	References
159	QEAFEISKKEMQPTH	acetylation	[1]
159	QEAFEISKKEMQPTH	ubiquitination	[2]

Reference

 [1] Proteomic investigations of lysine acetylation identify diverse substrates of mitochondrial deacetylase sirt3.
 Sol EM, Wagner SA, Weinert BT, Kumar A, Kim HS, Deng CX, Choudhary C.
 PLoS One. 2012;7(12):e50545. [PMID: 23236377]
 [2] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023] 

Functional Description

 Adapter protein implicated in the regulation of a large spectrum of both general and specialized signaling pathways. Binds to a large number of partners, usually by recognition of a phosphoserine or phosphothreonine motif. Binding generally results in the modulation of the activity of the binding partner. Negative regulator of osteogenesis. Blocks the nuclear translocation of the phosphorylated form (by AKT1) of SRPK2 and antagonizes its stimulatory effect on cyclin D1 expression resulting in blockage of neuronal apoptosis elicited by SRPK2 (By similarity). 

Sequence Annotation

 MOD_RES 1 1 N-acetylmethionine (By similarity).
 MOD_RES 2 2 N-acetylthreonine; in 14-3-3 protein
 MOD_RES 60 60 Phosphoserine.
 MOD_RES 70 70 N6-acetyllysine (By similarity).
 MOD_RES 84 84 Nitrated tyrosine.
 MOD_RES 106 106 Nitrated tyrosine.
 MOD_RES 117 117 N6-acetyllysine (By similarity).
 MOD_RES 186 186 Phosphoserine (By similarity).  

Keyword

 3D-structure; Acetylation; Alternative initiation; Complete proteome; Cytoplasm; Direct protein sequencing; Nitration; Phosphoprotein; Reference proteome. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 246 AA 

Protein Sequence

Gene Ontology

 GO:0030659; C:cytoplasmic vesicle membrane; TAS:Reactome.
 GO:0005829; C:cytosol; TAS:Reactome.
 GO:0042470; C:melanosome; IEA:UniProtKB-SubCell.
 GO:0048471; C:perinuclear region of cytoplasm; IEA:Compara.
 GO:0017053; C:transcriptional repressor complex; IEA:Compara.
 GO:0019904; F:protein domain specific binding; IDA:MGI.
 GO:0003714; F:transcription corepressor activity; IEA:Compara.
 GO:0051220; P:cytoplasmic sequestering of protein; IEA:Compara.
 GO:0035308; P:negative regulation of protein dephosphorylation; IEA:Compara.
 GO:0045892; P:negative regulation of transcription, DNA-dependent; IEA:Compara.
 GO:0043085; P:positive regulation of catalytic activity; IEA:Compara.
 GO:0051291; P:protein heterooligomerization; IEA:Compara.
 GO:0006605; P:protein targeting; IDA:MGI. 

Interpro

 IPR000308; 14-3-3.
 IPR023409; 14-3-3_CS.
 IPR023410; 14-3-3_domain. 

Pfam

 PF00244; 14-3-3 

SMART

 SM00101; 14_3_3 

PROSITE

 PS00796; 1433_1
 PS00797; 1433_2 

PRINTS

 PR00305; 1433ZETA.