CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-024792
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 FERM, RhoGEF and pleckstrin domain-containing protein 1 
Protein Synonyms/Alias
  
Gene Name
 Farp1 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Mus musculus (Mouse) 
NCBI Taxa ID
 10090 
Lysine Modification
Position
Peptide
Type
References
141YLFALQVKQDLAQGRubiquitination[1]
548DKAYYIAKEVSTTERubiquitination[1]
602KFHTNFLKEIEQRLAubiquitination[1]
632RIGDVMLKNIQGMKHubiquitination[1]
659EALETSIKGSRRLEHubiquitination[1]
696LHRLMHYKHVLERLCubiquitination[1]
748QKLHELKKDLIGIDNubiquitination[1]
771IRLGSLSKLSGKGLQubiquitination[1]
Reference
 [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023] 
Functional Description
 Functions as guanine nucleotide exchange factor for RAC1. May play a role in semaphorin signaling. Plays a role in the assembly and disassembly of dendritic filopodia, the formation of dendritic spines, regulation of dendrite length and ultimately the formation of synapses (By similarity). 
Sequence Annotation
 DOMAIN 40 320 FERM.
 DOMAIN 542 733 DH.
 DOMAIN 762 859 PH 1.
 DOMAIN 935 1032 PH 2.
 MOD_RES 24 24 Phosphothreonine (By similarity).
 MOD_RES 340 340 Phosphoserine (By similarity).
 MOD_RES 427 427 Phosphoserine (By similarity).
 MOD_RES 512 512 Phosphoserine (By similarity).
 MOD_RES 516 516 Phosphoserine (By similarity).
 MOD_RES 875 875 Phosphoserine (By similarity).
 MOD_RES 892 892 Phosphoserine (By similarity).  
Keyword
 Cell junction; Cell membrane; Cell projection; Complete proteome; Cytoplasm; Developmental protein; Guanine-nucleotide releasing factor; Membrane; Phosphoprotein; Reference proteome; Repeat; Synapse; Synaptosome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 1048 AA 
Protein Sequence
MGEIEQKPTP ASRLGAPENS GISTLERGQK PPPTPSGKLM TVKIQMLDDT QEAFEVPQRA 60
PGKVLFDAVC NHLNLVEGDY FGLEFPDHRK IVVWLDLLKP IVKQIRRPKH VVVKFVVKFF 120
PPDHTQLQEE LTRYLFALQV KQDLAQGRLT CNDTSAALLI SHIVQSEIGD FDEALDREHL 180
AKNKYVPQQD ALEDRIMEFH HSHVGQTPAE SDFQLLEVAR RLEMYGIRLH PAKDREGTKI 240
NLAVANTGIL VFQGFTKINA FNWAKVRKLS FKRKRFLIKL RPDVNSSYQD TLEFLMAGRD 300
FCKSFWKICV EHHAFFRLFE EPKPKPKPVL FSRGSSFRFS GRTQKQVLDY VKEGGHKKVQ 360
FERKHSKIHS TRSLVSQPTA PNSEVPKQSP QSASLTFGEG TESPGGQSCQ QAKETKACTL 420
ELGPHQSPAL PKSPPGSKAA DGTTVVPPEE EEEEEGGKDG IRPSNPQPPQ PSTGSLTGSP 480
HLSELSINSQ GGAAPANVTL SPNLSPDNKQ ASPLISPLLN DQACPRTDDE EEGRRKRFPT 540
DKAYYIAKEV STTERTYLKD LEVIASWFQS TVSKEDSMPE ALKSLIFPNF EPLHKFHTNF 600
LKEIEQRLAL WEGRSNAHVR GDYQRIGDVM LKNIQGMKHL AAHLWKHSEA LEALETSIKG 660
SRRLEHFCRD FELQKVCYLP LNTFLLRPLH RLMHYKHVLE RLCKHHPPNH ADFRDCRAAL 720
AEITEMVAQL HGTMIKMENF QKLHELKKDL IGIDNLVTPG REFIRLGSLS KLSGKGLQQR 780
MFFLFNDVLL YTSRGLTASN QFKVHGQLPL YGMTIEESEE EWGVPHCLTL RGQRQSIIVA 840
ASSRSEMEKW MEDIQMAIDL AEKSNGPTPE LLASSPPDNK SPDEATAADQ ESEDDLSASR 900
TSLERQAPHR GNTMVHVCWH RSTSVSMVDF SIAVENQLSG NLLRKFKNSN GWQKLWVVFT 960
NFCLFFYKSH QDSHPLASLP LLGYSLTIPS ESENIHKDYV FKLHFKSHVY YFRAESEYTF 1020
ERWMEVIRSA TSSASRAHIL SHKESHLY 1048 
Gene Ontology
 GO:0030054; C:cell junction; IEA:UniProtKB-KW.
 GO:0005856; C:cytoskeleton; IEA:InterPro.
 GO:0005829; C:cytosol; ISS:UniProtKB.
 GO:0030425; C:dendrite; ISS:UniProtKB.
 GO:0043197; C:dendritic spine; IEA:UniProtKB-SubCell.
 GO:0031234; C:extrinsic to internal side of plasma membrane; ISS:UniProtKB.
 GO:0030175; C:filopodium; IEA:UniProtKB-SubCell.
 GO:0045202; C:synapse; IEA:UniProtKB-SubCell.
 GO:0005543; F:phospholipid binding; IEA:InterPro.
 GO:0030676; F:Rac guanyl-nucleotide exchange factor activity; ISS:UniProtKB.
 GO:0048813; P:dendrite morphogenesis; ISS:UniProtKB.
 GO:0010923; P:negative regulation of phosphatase activity; IEA:Compara.
 GO:0035023; P:regulation of Rho protein signal transduction; IEA:InterPro.
 GO:0007416; P:synapse assembly; ISS:UniProtKB. 
Interpro
 IPR019749; Band_41_domain.
 IPR019750; Band_41_fam.
 IPR000219; DH-domain.
 IPR000798; Ez/rad/moesin_like.
 IPR014847; FERM-adjacent.
 IPR014352; FERM/acyl-CoA-bd_prot_3-hlx.
 IPR019748; FERM_central.
 IPR019747; FERM_CS.
 IPR000299; FERM_domain.
 IPR018979; FERM_N.
 IPR018980; FERM_PH-like_C.
 IPR011993; PH_like_dom.
 IPR001849; Pleckstrin_homology. 
Pfam
 PF08736; FA
 PF09380; FERM_C
 PF00373; FERM_M
 PF09379; FERM_N
 PF00169; PH
 PF00621; RhoGEF 
SMART
 SM00295; B41
 SM00233; PH
 SM00325; RhoGEF 
PROSITE
 PS00741; DH_1
 PS50010; DH_2
 PS00660; FERM_1
 PS00661; FERM_2
 PS50057; FERM_3
 PS50003; PH_DOMAIN 
PRINTS
 PR00935; BAND41.
 PR00661; ERMFAMILY.