UniProt Accession

 GLRX3_MOUSE; Q9CQM9; Q5I0V8; Q9JLZ2 

Genbank Protein ID

 AF118650; AK010354; AK017371; AK147158; AK152446; AK152634; AK155190; AK167672; BC033506; BC087885 

Genbank Nucleotide ID

 AAF28842.1; BAB26874.1; BAB30712.1; BAE27724.1; BAE31225.1; BAE31376.1; BAE33105.1; BAE39721.1; AAH33506.1; AAH87885.1 

Protein Name

 Glutaredoxin-3 

Protein Synonyms/Alias

 PKC-interacting cousin of thioredoxin; PICOT; PKC-theta-interacting protein; PKCq-interacting protein; Thioredoxin-like protein 2 

Gene Name

 Glrx3 

Gene Synonyms/Alias

 Picot; Txnl2 

Created Date

 July 27, 2013 

Organism

 Mus musculus (Mouse) 

NCBI Taxa ID

 10090 

Lysine Modification

Position	Peptide	Type	References
141	DLSLRLKKLTHAAPC	ubiquitination	[1]
153	APCMLFMKGTPQEPR	acetylation	[2]
153	APCMLFMKGTPQEPR	ubiquitination	[1]
242	PKLEERLKVLTNKAS	ubiquitination	[1]
321	VGGLDIVKELKDNGE	ubiquitination	[1]
324	LDIVKELKDNGELLP	ubiquitination	[1]

Reference

 [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023]
 [2] Quantitative acetylome analysis reveals the roles of SIRT1 in regulating diverse substrates and cellular pathways.
 Chen Y, Zhao W, Yang JS, Cheng Z, Luo H, Lu Z, Tan M, Gu W, Zhao Y.
 Mol Cell Proteomics. 2012 Oct;11(10):1048-62. [PMID: 22826441] 

Functional Description

 Critical negative regulator of cardiac hypertrophy and a positive inotropic regulator. May play a role in regulating the function of the thioredoxin system. Does not possess any thyoredoxin activity since it lacks the conserved motif that is essential for catalytic activity. Has an essential function in embryogenesis. 

Sequence Annotation

 DOMAIN 2 119 Thioredoxin.
 DOMAIN 144 238 Glutaredoxin 1.
 DOMAIN 239 337 Glutaredoxin 2.
 METAL 161 161 Iron-sulfur (2Fe-2S); shared with dimeric
 METAL 263 263 Iron-sulfur (2Fe-2S); shared with dimeric
 MOD_RES 2 2 N-acetylalanine (By similarity).  

Keyword

 3D-structure; Acetylation; Complete proteome; Cytoplasm; Direct protein sequencing; Iron; Iron-sulfur; Metal-binding; Reference proteome; Repeat. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 337 AA 

Protein Sequence

Gene Ontology

 GO:0005938; C:cell cortex; IEA:UniProtKB-SubCell.
 GO:0030018; C:Z disc; IDA:UniProtKB.
 GO:0009055; F:electron carrier activity; IEA:InterPro.
 GO:0051536; F:iron-sulfur cluster binding; IEA:UniProtKB-KW.
 GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
 GO:0015035; F:protein disulfide oxidoreductase activity; IEA:InterPro.
 GO:0045454; P:cell redox homeostasis; IEA:InterPro.
 GO:0010614; P:negative regulation of cardiac muscle hypertrophy; IMP:UniProtKB.
 GO:0002026; P:regulation of the force of heart contraction; IMP:UniProtKB. 

Interpro

 IPR002109; Glutaredoxin.
 IPR004480; Monothiol_GRX-rel.
 IPR012336; Thioredoxin-like_fold.
 IPR013766; Thioredoxin_domain. 

Pfam

 PF00462; Glutaredoxin
 PF00085; Thioredoxin 

SMART

  

PROSITE

 PS51354; GLUTAREDOXIN_2
 PS00194; THIOREDOXIN_1
 PS51352; THIOREDOXIN_2 

PRINTS