CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-041329
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
  
Protein Name
 Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN 
Protein Synonyms/Alias
  
Gene Name
 TEP1 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
411ARRISELKSYLSRQKubiquitination[1]
577TYLRGQLKEPGALPSubiquitination[1]
689EELALYGKRLEESPFubiquitination[1]
1851TGNMWQKKANTPETQubiquitination[1]
Reference
 [1] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961] 
Functional Description
  
Sequence Annotation
  
Keyword
 Complete proteome; Reference proteome; Repeat; WD repeat. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 1904 AA 
Protein Sequence
MLNRYRQALE TAVNLSVKHS LPLLPGRTVL VYLTDANADR LCPKSNPQGP PLNYALLLIG 60
MMITRAEQVD VVLCGGDTLK TAVLKAEEGI LKTAIKLQAQ VQEFDENDGW SLNTFGKYLL 120
SLAGQRVPVD RVILLGQSMD DGMINVAKQL YWQRVNSKCL FVGILLRRVQ YLSTDLNPND 180
VTLSGCTDAI LKFIAEHGAS HLLEHVGQMD KIFKIPPPPG KTGVQSLRPL EEDTPSPLAP 240
VSQQGWRSIR LFISSTFRDM HGERDLLLRS VLPALQARAA PHRISLHGID LRWGVTEEET 300
RRNRQLEVCL GEVENAQLFV GILGSRYGYI PPSYNLPDHP HFHWAQQYPS GRSVTEMEVM 360
QFLNRNQRLQ PSAQALIYFR DSSFLSSVPD AWKSDFVSES EEAARRISEL KSYLSRQKGI 420
TCRRYPCEWG GVAAGRPYVG GLEEFGQLVL QDVWNMIQKL YLQPGALLEQ PVSIPDDDLV 480
QATFQQLQKP PSPARPRLLQ DTVQRLMLPH GRLSLVTGQS GQGKTAFLAS LVSALQAPDG 540
AKVASLVFFH FSGARPDQGL ALTLLRRLCT YLRGQLKEPG ALPSTYRSLV WELQQRLLPK 600
SAESLHPGQT QVLIIDGADR LVDQNGQLIS DWIPKKLPRC VHLVLSVSSD AGLGETLEQS 660
QGAHVLALGP LEASARARLV REELALYGKR LEESPFNNQR ESGRPLYLRL VTDHLRLFTL 720
YEQVSERLRT LPATVPLLLQ HILSTLEKEH GPDVLPQALT ALEVTRSGLT VDQLHGVLSV 780
WRTLPKGTKS WEEAVAAGNS GDPYPMGPFA CLVQSLRSLL GEGPLERPGA RLCLPDGPLR 840
TAAKRCYGKR PGLEDTAHIL IAAQLWKTCD ADASGTFRSC PPEALGDLPY HLLQSGNRGL 900
LSKFLTNLHV VAAHLELGLV SRLLEAHALY ASSVPKEEQK LPEADVAVFR TFLRQQASIL 960
SQYPRLLPQQ AANQPLDSPL CHQASLLSRR WHLQHTLRWL NKPRTMKNQQ SSSLSLAVSS 1020
SPTAVAFSTN GQRAAVGTAN GTVYLLDLRT WQEEKSVVSG CDGISACLFL SDDTLFLTAF 1080
DGLLELWDLQ HGCRVLQTKA HQYQITGCCL SPDCRLLATV CLGGCLKLWD TVRGQLAFQH 1140
TYPKSLNCVA FHPEGQVIAT GSWAGSISFF QVDGLKVTKD LGAPGASIRT LAFNVPGGVV 1200
AVGRLDSMVE LWAWREGARL AAFPAHHGFV AAALFLHAGC QLLTAGEDGK VQVWSGSLGR 1260
PRGHLGSLSL SPALSVALSP DGDRVAVGYR ADGIRIYKIS SGSQGAQGQA LDVAVSALAW 1320
LSPKVLVSGA EDGSLQGWAL KECSLQSLWL LSRFQKPVLG LATSQELLAS ASEDFTVQLW 1380
PRQLLTRPHK AEDFPCGTEL RGHEGPVSCC SFSTDGGSLA TGGRDRSLLC WDVRTPKTPV 1440
LIHSFPACHR DWVTGCAWTK DNLLISCSSD GSVGLWDPES GQRLGQFLGH QSAVSAVAAV 1500
EEHVVSVSRD GTLKVWDHQG VELTSIPAHS GPISHCAAAM EPRAAGQPGS ELLVVTVGLD 1560
GATRLWHPLL VCQTHTLLGH SGPVRAAAVS ETSGLMLTAS EDGSVRLWQV PKEADDTCIP 1620
RSSAAVTAVA WAPDGSMAVS GNQAGELILW QEAKAVATAQ APGHIGALIW SSAHTFFVLS 1680
ADEKISEWQV KLRKGSAPGN LSLHLNRILQ EDLGVLTSLD WAPDGHFLIL AKADLKLLCM 1740
KPGDAPSEIW SSYTENPMIL STHKEYGIFV LQPKDPGVLS FLRQKESGEF EERLNFDINL 1800
ENPSRTLISI TQAKPESESS FLCASSDGIL WNLAKCSPEG EWTTGNMWQK KANTPETQTP 1860
GTDPSTCRES DASMDSDASM DSEPTPHLKT RQRRKPSMCY LSCW 1904 
Gene Ontology
  
Interpro
 IPR025139; DUF4062.
 IPR007111; NACHT_NTPase.
 IPR015943; WD40/YVTN_repeat-like_dom.
 IPR001680; WD40_repeat.
 IPR019775; WD40_repeat_CS.
 IPR017986; WD40_repeat_dom. 
Pfam
 PF13271; DUF4062
 PF00400; WD40 
SMART
 SM00320; WD40 
PROSITE
 PS50837; NACHT
 PS00678; WD_REPEATS_1
 PS50082; WD_REPEATS_2
 PS50294; WD_REPEATS_REGION 
PRINTS