CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-020482
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Ribonuclease T2 
Protein Synonyms/Alias
 Ribonuclease 6 
Gene Name
 Rnaset2 
Gene Synonyms/Alias
 Rnase6pl 
Created Date
 July 27, 2013 
Organism
 Mus musculus (Mouse) 
NCBI Taxa ID
 10090 
Lysine Modification
Position
Peptide
Type
References
147GKSLDLYKQIDLNSVubiquitination[1]
Reference
 [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023] 
Functional Description
 Has ribonuclease activity, with higher activity at acidic pH. May play a role in cellular RNA catabolism. Probably is involved in lysosomal degradation of ribosomal RNA (By similarity). 
Sequence Annotation
 ACT_SITE 69 69 By similarity.
 ACT_SITE 118 118 By similarity.
 ACT_SITE 122 122 By similarity.
 CARBOHYD 80 80 N-linked (GlcNAc...) (Potential).
 CARBOHYD 110 110 N-linked (GlcNAc...) (Potential).
 CARBOHYD 216 216 N-linked (GlcNAc...) (Potential).
 DISULFID 53 59 By similarity.
 DISULFID 79 125 By similarity.
 DISULFID 188 244 By similarity.
 DISULFID 206 217 By similarity.  
Keyword
 Complete proteome; Disulfide bond; Endonuclease; Endoplasmic reticulum; Glycoprotein; Hydrolase; Lysosome; Nuclease; Reference proteome; Secreted; Signal. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 259 AA 
Protein Sequence
MAPAEARGAL PGWISVLGWG LALCSLCGAG PLWSGSHEWK KLILTQHWPP TVCKEVNSCQ 60
DSLDYWTIHG LWPDRAEDCN QSWHFNLDEI KDLLRDMKIY WPDVIHRSSN RSQFWKHEWV 120
KHGTCAAQVD ALNSEKKYFG KSLDLYKQID LNSVLQKFGI KPSINYYQLA DFKDALTRIY 180
GVVPKIQCLM PEQGESVQTV GQIELCFTKE DLHLRNCTEP GEQLSSRQEA WLAMEASTHG 240
MMVCEDGPIF YPPPTKTQH 259 
Gene Ontology
 GO:0005788; C:endoplasmic reticulum lumen; ISS:UniProtKB.
 GO:0005615; C:extracellular space; ISS:UniProtKB.
 GO:0043202; C:lysosomal lumen; IEA:UniProtKB-SubCell.
 GO:0005764; C:lysosome; ISS:UniProtKB.
 GO:0004540; F:ribonuclease activity; ISS:UniProtKB.
 GO:0033897; F:ribonuclease T2 activity; IEA:InterPro.
 GO:0003723; F:RNA binding; IEA:InterPro.
 GO:0006401; P:RNA catabolic process; ISS:UniProtKB. 
Interpro
 IPR001568; RNase_T2-like.
 IPR018188; RNase_T2_AS. 
Pfam
 PF00445; Ribonuclease_T2 
SMART
  
PROSITE
 PS00530; RNASE_T2_1
 PS00531; RNASE_T2_2 
PRINTS