CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-021014
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Plasmolipin 
Protein Synonyms/Alias
 Plasma membrane proteolipid 
Gene Name
 Pllp 
Gene Synonyms/Alias
 Plapi; Pmlp; Tm4sf11 
Created Date
 July 27, 2013 
Organism
 Mus musculus (Mouse) 
NCBI Taxa ID
 10090 
Lysine Modification
Position
Peptide
Type
References
7*MAEFPSKVSTRTSSubiquitination[1]
Reference
 [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023
Functional Description
 Appears to be involved in myelination. Could also participate in ion transport events as addition of plasmolipin to lipid bilayers induces the formation of ion channels, which are voltage-dependent and K(+)-selective (By similarity). 
Sequence Annotation
 DOMAIN 32 166 MARVEL.  
Keyword
 Complete proteome; Ion channel; Ion transport; Membrane; Reference proteome; Transmembrane; Transmembrane helix; Transport. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 182 AA 
Protein Sequence
MAEFPSKVST RTSSPAQGVG ASVSALRPDL GFVRSALGVL ALLQLALGLL VWALIADTPY 60
HLYPAYGWVM FVAVFLWLVT IVFFIIYLFQ LHMKLYMVPW PLVLLIFFVA ATVLYITAFI 120
ACAAAVDLTS LRGSRPYNQR SAASFFACLV MIAYGVSAFF SFQAWRGVGS NAATSQMAGG 180
YS 182 
Gene Ontology
 GO:0043218; C:compact myelin; IEA:Compara.
 GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.
 GO:0045121; C:membrane raft; IEA:Compara.
 GO:0006811; P:ion transport; IEA:UniProtKB-KW.
 GO:0042552; P:myelination; IEA:Compara.
 GO:0009611; P:response to wounding; IEA:Compara. 
Interpro
 IPR013295; MAL.
 IPR008253; Marvel.
 IPR021128; MARVEL-like_dom. 
Pfam
 PF01284; MARVEL 
SMART
  
PROSITE
 PS51225; MARVEL 
PRINTS
 PR01884; MALPROTEIN.