| Tag | Content |
|---|
| CPLM ID | CPLM-011072 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | Down-regulator of invasive growth 2 |
Protein Synonyms/Alias | Regulator of STE12 protein 2; Regulator of sterile twelve 2 |
Gene Name | DIG2 |
Gene Synonyms/Alias | RST2; YDR480W; D8035.23 |
Created Date | July 27, 2013 |
Organism | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) |
NCBI Taxa ID | 559292 |
Lysine Modification | Position | Peptide | Type | References |
|---|
| 88 | ITTSPAEKTVPFKSL | acetylation | [1] |
|
Reference | [1] Proteome-wide analysis of lysine acetylation suggests its broad regulatory scope in Saccharomyces cerevisiae. Henriksen P, Wagner SA, Weinert BT, Sharma S, Bacinskaja G, Rehman M, Juffer AH, Walther TC, Lisby M, Choudhary C. Mol Cell Proteomics. 2012 Nov;11(11):1510-22. [ PMID: 22865919] |
Functional Description | DIG2 and DIG1 are negative regulators of the filamentation and pheromone induced mating program. DIG1 and DIG2 inhibit the transcriptional activity of STE12 by direct protein- protein interaction. DIG2 binds to the DNA binding domain (DBD) of STE12 and thus inhibits transcription when overexpressed. |
Sequence Annotation | MOD_RES 34 34 Phosphoserine.
MOD_RES 225 225 Phosphoserine.
MOD_RES 266 266 Phosphoserine.
MOD_RES 270 270 Phosphoserine. |
Keyword | Complete proteome; Nucleus; Phosphoprotein; Reference proteome. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 323 AA |
Protein Sequence | MNKEEQEDPQ QEQISTVQEN DPRNLQQLGM LLVSPGLDED RLSEKMISKI KKSRDIEKNQ 60
KLLISRLSQK EEDHSGKPPT ITTSPAEKTV PFKSLNHSLK RKRVPPALNF SDIQASSHLH 120
GSKSAPPNIT RFPQHKNSLR VRYMGRMAPT NQDYHPSVAN SYMTATYPYP YTGLPPVPCY 180
PYSSTPTQTH AYEGYYSPMY PGPLYNNGII PADYHAKRKK LAGRSPHLED LTSRKRTFVS 240
KHHNGDPIIS KTDEDIECSV TKNSLSEGAS LNDDADDDND KERIIIGEIS LYDDVFKFEV 300
RDDKNDYMKA CETIWTEWHN LKK 323 |
Gene Ontology | GO:0005634; C:nucleus; IDA:SGD. GO:0008134; F:transcription factor binding; IDA:SGD. GO:2000218; P:negative regulation of invasive growth in response to glucose limitation; IGI:SGD. GO:2000221; P:negative regulation of pseudohyphal growth; IGI:SGD. GO:0046020; P:negative regulation of transcription from RNA polymerase II promoter by pheromones; IGI:SGD. |
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SMART | |
PROSITE | |
PRINTS | |