CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-003953
UniProt Accession
Genbank Protein ID
 X12875 
Genbank Nucleotide ID
Protein Name
 Neural cell adhesion molecule L1 
Protein Synonyms/Alias
 N-CAM-L1; NCAM-L1; CD171 
Gene Name
 L1cam 
Gene Synonyms/Alias
 Caml1 
Created Date
 July 27, 2013 
Organism
 Mus musculus (Mouse) 
NCBI Taxa ID
 10090 
Lysine Modification
Position
Peptide
Type
References
1172DSEARPMKDETFGEYubiquitination[1]
Reference
 [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023] 
Functional Description
 Cell adhesion molecule with an important role in the development of the nervous system. Involved in neuron-neuron adhesion, neurite fasciculation, outgrowth of neurites, etc. Binds to axonin on neurons. 
Sequence Annotation
 DOMAIN 35 130 Ig-like C2-type 1.
 DOMAIN 138 225 Ig-like C2-type 2.
 DOMAIN 239 327 Ig-like C2-type 3.
 DOMAIN 332 419 Ig-like C2-type 4.
 DOMAIN 424 506 Ig-like C2-type 5.
 DOMAIN 517 600 Ig-like C2-type 6.
 DOMAIN 611 708 Fibronectin type-III 1.
 DOMAIN 713 806 Fibronectin type-III 2.
 DOMAIN 811 912 Fibronectin type-III 3.
 DOMAIN 913 1011 Fibronectin type-III 4.
 DOMAIN 1014 1112 Fibronectin type-III 5.
 MOTIF 553 555 Cell attachment site (Potential).
 MOTIF 562 564 Cell attachment site (Potential).
 MOD_RES 1166 1166 Phosphoserine (By similarity).
 MOD_RES 1184 1184 Phosphoserine; by CaMK2.
 MOD_RES 1197 1197 Phosphoserine.
 MOD_RES 1250 1250 Phosphothreonine.
 MOD_RES 1251 1251 Phosphoserine.
 CARBOHYD 100 100 N-linked (GlcNAc...) (Potential).
 CARBOHYD 202 202 N-linked (GlcNAc...) (Potential).
 CARBOHYD 246 246 N-linked (GlcNAc...) (Potential).
 CARBOHYD 293 293 N-linked (GlcNAc...) (Potential).
 CARBOHYD 432 432 N-linked (GlcNAc...) (Potential).
 CARBOHYD 478 478 N-linked (GlcNAc...) (Potential).
 CARBOHYD 489 489 N-linked (GlcNAc...) (Potential).
 CARBOHYD 504 504 N-linked (GlcNAc...) (Potential).
 CARBOHYD 587 587 N-linked (GlcNAc...) (Potential).
 CARBOHYD 670 670 N-linked (GlcNAc...).
 CARBOHYD 725 725 N-linked (GlcNAc...).
 CARBOHYD 776 776 N-linked (GlcNAc...) (Potential).
 CARBOHYD 824 824 N-linked (GlcNAc...) (Potential).
 CARBOHYD 848 848 N-linked (GlcNAc...) (Potential).
 CARBOHYD 875 875 N-linked (GlcNAc...) (Potential).
 CARBOHYD 968 968 N-linked (GlcNAc...).
 CARBOHYD 978 978 N-linked (GlcNAc...).
 CARBOHYD 1022 1022 N-linked (GlcNAc...) (Potential).
 CARBOHYD 1030 1030 N-linked (GlcNAc...) (Potential).
 CARBOHYD 1073 1073 N-linked (GlcNAc...) (Potential).
 CARBOHYD 1107 1107 N-linked (GlcNAc...) (Potential).
 DISULFID 57 113 By similarity.
 DISULFID 157 208 By similarity.
 DISULFID 263 311 By similarity.
 DISULFID 353 403 By similarity.
 DISULFID 447 496 By similarity.
 DISULFID 538 590 By similarity.  
Keyword
 Cell adhesion; Cell membrane; Complete proteome; Developmental protein; Differentiation; Direct protein sequencing; Disulfide bond; Glycoprotein; Immunoglobulin domain; Membrane; Neurogenesis; Phosphoprotein; Reference proteome; Repeat; Signal; Transmembrane; Transmembrane helix. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 1260 AA 
Protein Sequence
MVVMLRYVWP LLLCSPCLLI QIPDEYKGHH VLEPPVITEQ SPRRLVVFPT DDISLKCEAR 60
GRPQVEFRWT KDGIHFKPKE ELGVVVHEAP YSGSFTIEGN NSFAQRFQGI YRCYASNKLG 120
TAMSHEIQLV AEGAPKWPKE TVKPVEVEEG ESVVLPCNPP PSAAPPRIYW MNSKIFDIKQ 180
DERVSMGQNG DLYFANVLTS DNHSDYICNA HFPGTRTIIQ KEPIDLRVKP TNSMIDRKPR 240
LLFPTNSSSR LVALQGQSLI LECIAEGFPT PTIKWLHPSD PMPTDRVIYQ NHNKTLQLLN 300
VGEEDDGEYT CLAENSLGSA RHAYYVTVEA APYWLQKPQS HLYGPGETAR LDCQVQGRPQ 360
PEITWRINGM SMETVNKDQK YRIEQGSLIL SNVQPTDTMV TQCEARNQHG LLLANAYIYV 420
VQLPARILTK DNQTYMAVEG STAYLLCKAF GAPVPSVQWL DEEGTTVLQD ERFFPYANGT 480
LSIRDLQAND TGRYFCQAAN DQNNVTILAN LQVKEATQIT QGPRSAIEKK GARVTFTCQA 540
SFDPSLQASI TWRGDGRDLQ ERGDSDKYFI EDGKLVIQSL DYSDQGNYSC VASTELDEVE 600
SRAQLLVVGS PGPVPHLELS DRHLLKQSQV HLSWSPAEDH NSPIEKYDIE FEDKEMAPEK 660
WFSLGKVPGN QTSTTLKLSP YVHYTFRVTA INKYGPGEPS PVSESVVTPE AAPEKNPVDV 720
RGEGNETNNM VITWKPLRWM DWNAPQIQYR VQWRPQGKQE TWRKQTVSDP FLVVSNTSTF 780
VPYEIKVQAV NNQGKGPEPQ VTIGYSGEDY PQVSPELEDI TIFNSSTVLV RWRPVDLAQV 840
KGHLKGYNVT YWWKGSQRKH SKRHIHKSHI VVPANTTSAI LSGLRPYSSY HVEVQAFNGR 900
GLGPASEWTF STPEGVPGHP EALHLECQSD TSLLLHWQPP LSHNGVLTGY LLSYHPVEGE 960
SKEQLFFNLS DPELRTHNLT NLNPDLQYRF QLQATTQQGG PGEAIVREGG TMALFGKPDF 1020
GNISATAGEN YSVVSWVPRK GQCNFRFHIL FKALPEGKVS PDHQPQPQYV SYNQSSYTQW 1080
NLQPDTKYEI HLIKEKVLLH HLDVKTNGTG PVRVSTTGSF ASEGWFIAFV SAIILLLLIL 1140
LILCFIKRSK GGKYSVKDKE DTQVDSEARP MKDETFGEYR SLESDNEEKA FGSSQPSLNG 1200
DIKPLGSDDS LADYGGSVDV QFNEDGSFIG QYSGKKEKEA AGGNDSSGAT SPINPAVALE 1260 
Gene Ontology
 GO:0009897; C:external side of plasma membrane; IDA:MGI.
 GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.
 GO:0042734; C:presynaptic membrane; IDA:MGI.
 GO:0043195; C:terminal bouton; IDA:MGI.
 GO:0042802; F:identical protein binding; IDA:MGI.
 GO:0005178; F:integrin binding; IDA:MGI.
 GO:0033691; F:sialic acid binding; IDA:MGI.
 GO:0007411; P:axon guidance; IDA:MGI.
 GO:0007166; P:cell surface receptor signaling pathway; IDA:MGI.
 GO:0033631; P:cell-cell adhesion mediated by integrin; IMP:MGI.
 GO:0007157; P:heterophilic cell-cell adhesion; IMP:MGI.
 GO:0007156; P:homophilic cell adhesion; IMP:MGI.
 GO:0034109; P:homotypic cell-cell adhesion; IMP:MGI.
 GO:0007159; P:leukocyte cell-cell adhesion; IMP:MGI.
 GO:0050850; P:positive regulation of calcium-mediated signaling; IDA:MGI.
 GO:0022409; P:positive regulation of cell-cell adhesion; IMP:MGI. 
Interpro
 IPR026966; Fibronectin_III_C.
 IPR003961; Fibronectin_type3.
 IPR007110; Ig-like_dom.
 IPR013783; Ig-like_fold.
 IPR013098; Ig_I-set.
 IPR003599; Ig_sub.
 IPR003598; Ig_sub2. 
Pfam
 PF13882; Bravo_FIGEY
 PF00041; fn3
 PF07679; I-set 
SMART
 SM00060; FN3
 SM00409; IG
 SM00408; IGc2 
PROSITE
 PS50853; FN3
 PS50835; IG_LIKE 
PRINTS