CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-012407
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Inactive dual specificity phosphatase 27 
Protein Synonyms/Alias
  
Gene Name
 Dusp27 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Mus musculus (Mouse) 
NCBI Taxa ID
 10090 
Lysine Modification
Position
Peptide
Type
References
71QIINEELKPRGLRTDubiquitination[1]
446SHDIRILKQQLERSTubiquitination[1]
483ERLVEIEKEAARKYRubiquitination[1]
494RKYRSKSKREELDGDubiquitination[1]
534FCSRNKDKLTPLERWubiquitination[1]
Reference
 [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023
Functional Description
  
Sequence Annotation
 DOMAIN 201 259 Tyrosine-protein phosphatase.  
Keyword
 Complete proteome; Reference proteome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 1138 AA 
Protein Sequence
MATGGDAEEE QVVPNEEDEA DVRAVQARYL RSPSPSQYSV VSEAETESIF MEPIHLSSAV 60
AAKQIINEEL KPRGLRTDTE CPGMLESAEQ LLVEDLYNRV REKMDDRSLF NTPCVLDLQR 120
ALTQDRQEAP RNEVDEVWPN VFIAEKSVAV NKGRLKRLGI THILNAAHGT GVYTGSEFYT 180
GLEIQYLGVE VDDFPEVDIS QHFRKAAEFL DEALLTYRGK VLVSSEMGIS RSAVLVVAYL 240
MIFHSMAILE ALMTVRRKRA IYPNDGFLKQ LRELNEKLME EREEEDGEEE SEEDAGSMLG 300
ARVNSLMVEE EDDATSHLSG SSLGKASQVS KPVTLIDDEE EEKKLYEEWR KGQGFPKGEA 360
AQGRKGRSCS MSSAQDGDDC EDEDVERIIQ EWQSRNERYQ AKGREQWNRE EEEEEENSYS 420
SRRRRHTLSE SSASESVSSH DIRILKQQLE RSTQSRRGRY RSDSESSEST WDMWNERLVE 480
IEKEAARKYR SKSKREELDG DCSEAGGRVR EDDEESVLSE ASSFYNFCSR NKDKLTPLER 540
WKIKRIQFGF HKKDSEAGDG GSEHGTEEAA AGEKNLSDVN LTAYQAWKLK HQKKVGSENK 600
EEVVEMSKGE DTVLAKKRQR RLELLERSRQ TLEESQSMGS WEADSSTASR SIPLSAFSSA 660
APSVSADGDT ASVLSTQSHR SHASNMPATP LPNLPVGPGD TISIASIQNW IANVVNETLA 720
QKQNEMLLLS RPPSVASMKA APAACGLGGD DQLSVLSTSL SGCLPPPSQG RPSSDVQSVL 780
SSTSSLTSRA EGSGNKVRGT SKPIYSLFAD NVDLKELGRK EKEMQMELQE KMSEYKMEKL 840
ASDNKRSSLF KKKKAKDDED MSVGDRDEDT DSAIGSFRYS SRSNSQKPET DASSSLAISD 900
HYRNGRSMGN EMDSNINTWL SGLRMEEKSP PQSDWSGSSR GRYTRSSLLR ETESKSCSYK 960
FSKSRSQEQD TSFHEANGDT VRNTSRFSSS TTKEAREMHK FSRSTFSETS SSREESPEPY 1020
FFRRTPEPSD GEESPEPRRP NWTRPRDWED VEESSKSDFA EFGAKRKFTQ SFMRSEEEGE 1080
KERTENREEG RFASGRQSQY RRSTNQQEEE EMDDEAIIAA WRKRQEETRT KLQRRRED 1138 
Gene Ontology
 GO:0008138; F:protein tyrosine/serine/threonine phosphatase activity; IBA:RefGenome.
 GO:0006470; P:protein dephosphorylation; IBA:RefGenome. 
Interpro
 IPR020417; Atypical_DUSP.
 IPR020405; Atypical_DUSP_famA.
 IPR000340; Dual-sp_phosphatase_cat-dom.
 IPR020422; Dual-sp_phosphatase_subgr_cat.
 IPR024950; DUSP.
 IPR000387; Tyr/Dual-sp_Pase. 
Pfam
 PF00782; DSPc 
SMART
 SM00195; DSPc 
PROSITE
 PS00383; TYR_PHOSPHATASE_1
 PS50056; TYR_PHOSPHATASE_2
 PS50054; TYR_PHOSPHATASE_DUAL 
PRINTS
 PR01908; ADSPHPHTASE.
 PR01909; ADSPHPHTASEA.