CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-024615
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Putative zinc finger protein 487 
Protein Synonyms/Alias
 KRAB domain only protein 1 
Gene Name
 ZNF487 
Gene Synonyms/Alias
 KRBO1; ZNF487P 
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
200AECNVRGKFLLCMKRubiquitination[1]
Reference
 [1] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961
Functional Description
 May be involved in transcriptional regulation (By similarity). 
Sequence Annotation
 DOMAIN 37 108 KRAB 1.
 DOMAIN 433 447 KRAB 2.
 ZN_FING 286 308 C2H2-type 1.
 ZN_FING 314 336 C2H2-type 2.
 ZN_FING 355 378 C2H2-type 3; degenerate.  
Keyword
 Complete proteome; DNA-binding; Metal-binding; Nucleus; Polymorphism; Reference proteome; Repeat; Transcription; Transcription regulation; Zinc; Zinc-finger. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 448 AA 
Protein Sequence
MASRPRPRTP SRGPSDLRFR GEAGLRRVFL KKAGGSVSFS DVAVGFTQEE WQHLDSAQRT 60
PYRDMMLENY SLLLSVGYCI TKPEVVCKLE HGQVLWILEE ESPSQSHLDC CIDDDLMEKR 120
QENQDQHLQK VDFVNNKTLT MDRNGVLGKT FSLDTNPILS RKIRGNCDSS GMNLNNISEL 180
IISNRSSFVR NPAECNVRGK FLLCMKRENP YARGKPLEYD GNGKAVSQNE DLFRHQYIQT 240
LKQCFEYNHR GYTEERNPMN ALNVGKLLDI GHALQYIKEH TRDKTYECNE CGKNFCEKSN 300
LHVHQRTHTG EKPYGCNECQ KAFGDRSALK VHQRIHTGEK PYELHQRTHT GEKPYACSEC 360
GKTFYQKSSL TTHQRTHTRE QPYEYNESFY QNPNFTKCQR DNIEETLVNI LKAQKPSPSW 420
TRSIAETTQV GGSVSLKDVT VDFTQEEW 448 
Gene Ontology
 GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
 GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
 GO:0008270; F:zinc ion binding; IEA:InterPro.
 GO:0006355; P:regulation of transcription, DNA-dependent; IEA:UniProtKB-KW.
 GO:0006351; P:transcription, DNA-dependent; IEA:UniProtKB-KW. 
Interpro
 IPR001909; Krueppel-associated_box.
 IPR007087; Znf_C2H2.
 IPR015880; Znf_C2H2-like.
 IPR013087; Znf_C2H2/integrase_DNA-bd. 
Pfam
 PF01352; KRAB
 PF00096; zf-C2H2 
SMART
 SM00349; KRAB
 SM00355; ZnF_C2H2 
PROSITE
 PS50805; KRAB
 PS00028; ZINC_FINGER_C2H2_1
 PS50157; ZINC_FINGER_C2H2_2 
PRINTS