CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-024416
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 GTP-binding protein 10 
Protein Synonyms/Alias
 Protein obg homolog 2; ObgH2 
Gene Name
 GTPBP10 
Gene Synonyms/Alias
 OBGH2; UG0751c10 
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
184DYAFTTLKPELGKIMacetylation[1]
308DFLHLFEKNMIPERTubiquitination[2]
Reference
 [1] Proteomic investigations of lysine acetylation identify diverse substrates of mitochondrial deacetylase sirt3.
 Sol EM, Wagner SA, Weinert BT, Kumar A, Kim HS, Deng CX, Choudhary C.
 PLoS One. 2012;7(12):e50545. [PMID: 23236377]
 [2] Systematic and quantitative assessment of the ubiquitin-modified proteome.
 Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
 Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983] 
Functional Description
 May be involved in the ribosome maturation process. Complements an ObgE(CgtA) function in E.coli ribosome maturation. Plays a role of GTPase in vitro. When missing, disorganization of the nuceleolar architecture is observed. 
Sequence Annotation
 NP_BIND 155 162 GTP (Potential).
 NP_BIND 202 206 GTP (Potential).
 NP_BIND 278 281 GTP (Potential).  
Keyword
 Alternative splicing; Chromosome; Complete proteome; GTP-binding; Nucleotide-binding; Nucleus; Polymorphism; Reference proteome; Ribosome biogenesis. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 387 AA 
Protein Sequence
MVHCSCVLFR KYGNFIDKLR LFTRGGSGGM GYPRLGGEGG KGGDVWVVAQ NRMTLKQLKD 60
RYPRKRFVAG VGANSKISAL KGSKGKDCEI PVPVGISVTD ENGKIIGELN KENDRILVAQ 120
GGLGGKLLTN FLPLKGQKRI IHLDLKLIAD VGLVGFPNAG KSSLLSCVSH AKPAIADYAF 180
TTLKPELGKI MYSDFKQISV ADLPGLIEGA HMNKGMGHKF LKHIERTRQL LFVVDISGFQ 240
LSSHTQYRTA FETIILLTKE LELYKEELQT KPALLAVNKM DLPDAQDKFH ELMSQLQNPK 300
DFLHLFEKNM IPERTVEFQH IIPISAVTGE GIEELKNCIR KSLDEQANQE NDALHKKQLL 360
NLWISDTMSS TEPPSKHAVT TSKMDII 387 
Gene Ontology
 GO:0005694; C:chromosome; IEA:UniProtKB-SubCell.
 GO:0005739; C:mitochondrion; IEA:Compara.
 GO:0005730; C:nucleolus; IEA:UniProtKB-SubCell.
 GO:0005525; F:GTP binding; IEA:UniProtKB-KW.
 GO:0003924; F:GTPase activity; IEA:InterPro.
 GO:0000287; F:magnesium ion binding; IEA:InterPro.
 GO:0006184; P:GTP catabolic process; IEA:GOC.
 GO:0042254; P:ribosome biogenesis; IEA:UniProtKB-KW. 
Interpro
 IPR014100; GTP-bd_Obg/CgtA.
 IPR006169; GTP1_OBG_dom.
 IPR006073; GTP_binding_domain.
 IPR027417; P-loop_NTPase. 
Pfam
 PF01018; GTP1_OBG
 PF01926; MMR_HSR1 
SMART
  
PROSITE
  
PRINTS
 PR00326; GTP1OBG.