UniProt Accession

 SO4A1_HUMAN; Q96BD0; Q9H4T7; Q9H4T8; Q9H8P2; Q9NWX8; Q9UI35; Q9UIG7 

Genbank Protein ID

 AB031051; AF187817; AF104334; AF205072; AK023410; AK000551; AL357033; AL357033; BC015727 

Genbank Nucleotide ID

 BAA89288.1; AAG43447.1; AAF15545.1; AAG42204.1; BAB14566.1; BAA91247.1; CAC14920.1; CAC14921.1; AAH15727.1 

Protein Name

 Solute carrier organic anion transporter family member 4A1 

Protein Synonyms/Alias

 OATP4A1; Colon organic anion transporter; Organic anion transporter polypeptide-related protein 1; OATP-RP1; OATPRP1; POAT; Organic anion-transporting polypeptide E; OATP-E; Sodium-independent organic anion transporter E; Solute carrier family 21 member 12 

Gene Name

 SLCO4A1 

Gene Synonyms/Alias

 OATP1; OATP4A1; OATPE; SLC21A12 

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
56	HSPLDTSKQPLCQLW	ubiquitination	[1, 2, 3]
66	LCQLWAEKHGARGTH	ubiquitination	[3]
353	AAEMHQLKDSSRGEA	ubiquitination	[1, 3, 4]
367	ASNPDFGKTIRDLPL	ubiquitination	[1, 3, 4]
569	FGHATAGKCTSTCQR	ubiquitination	[5]

Reference

 [1] Ubiquitin ligase substrate identification through quantitative proteomics at both the protein and peptide levels.
 Lee KA, Hammerle LP, Andrews PS, Stokes MP, Mustelin T, Silva JC, Black RA, Doedens JR.
 J Biol Chem. 2011 Dec 2;286(48):41530-8. [PMID: 21987572]
 [2] Methods for quantification of in vivo changes in protein ubiquitination following proteasome and deubiquitinase inhibition.
 Udeshi ND, Mani DR, Eisenhaure T, Mertins P, Jaffe JD, Clauser KR, Hacohen N, Carr SA.
 Mol Cell Proteomics. 2012 May;11(5):148-59. [PMID: 22505724]
 [3] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961]
 [4] Systematic and quantitative assessment of the ubiquitin-modified proteome.
 Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
 Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983]
 [5] Global identification of modular cullin-RING ligase substrates.
 Emanuele MJ, Elia AE, Xu Q, Thoma CR, Izhar L, Leng Y, Guo A, Chen YN, Rush J, Hsu PW, Yen HC, Elledge SJ.
 Cell. 2011 Oct 14;147(2):459-74. [PMID: 21963094] 

Functional Description

 Mediates the Na(+)-independent transport of organic anions such as the thyroid hormones T3 (triiodo-L-thyronine), T4 (thyroxine) and rT3, and of estrone-3-sulfate and taurocholate. 

Sequence Annotation

 DOMAIN 498 555 Kazal-like.
 MOD_RES 34 34 Phosphoserine.
 MOD_RES 37 37 Phosphothreonine.
 MOD_RES 40 40 Phosphoserine.
 MOD_RES 43 43 Phosphoserine.
 MOD_RES 46 46 Phosphoserine.
 MOD_RES 50 50 Phosphoserine.
 CARBOHYD 499 499 N-linked (GlcNAc...) (Potential).
 CARBOHYD 557 557 N-linked (GlcNAc...) (Potential).
 DISULFID 504 530 By similarity.
 DISULFID 508 519 By similarity.
 DISULFID 510 534 By similarity.  

Keyword

 Alternative splicing; Cell membrane; Complete proteome; Disulfide bond; Glycoprotein; Ion transport; Membrane; Phosphoprotein; Polymorphism; Reference proteome; Transmembrane; Transmembrane helix; Transport. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 722 AA 

Protein Sequence

Gene Ontology

 GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.
 GO:0005886; C:plasma membrane; TAS:Reactome.
 GO:0005215; F:transporter activity; IEA:InterPro.
 GO:0043252; P:sodium-independent organic anion transport; TAS:Reactome.
 GO:0055085; P:transmembrane transport; TAS:Reactome. 

Interpro

 IPR002350; Kazal_dom.
 IPR020846; MFS_dom.
 IPR016196; MFS_dom_general_subst_transpt.
 IPR004156; OA_transporter. 

Pfam

 PF07648; Kazal_2
 PF03137; OATP 

SMART

 SM00280; KAZAL 

PROSITE

 PS51465; KAZAL_2
 PS50850; MFS 

PRINTS