| Tag | Content |
|---|
| CPLM ID | CPLM-009110 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | F-box/WD repeat-containing protein 4 |
Protein Synonyms/Alias | Dactylin; F-box and WD-40 domain-containing protein 4 |
Gene Name | FBXW4 |
Gene Synonyms/Alias | FBW4; SHFM3 |
Created Date | July 27, 2013 |
Organism | Homo sapiens (Human) |
NCBI Taxa ID | 9606 |
Lysine Modification | Position | Peptide | Type | References |
|---|
| 94 | LMTSVPVKERVKVSQ | ubiquitination | [1] | | 98 | VPVKERVKVSQNWRL | ubiquitination | [1] |
|
Reference | [1] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments. Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA. Mol Cell Proteomics. 2013 Mar;12(3):825-31. [ PMID: 23266961] |
Functional Description | Probably recognizes and binds to some phosphorylated proteins and promotes their ubiquitination and degradation. Likely to be involved in key signaling pathways crucial for normal limb development. May participate in Wnt signaling. |
Sequence Annotation | DOMAIN 25 71 F-box.
REPEAT 161 198 WD 1.
REPEAT 200 237 WD 2.
REPEAT 291 329 WD 3.
REPEAT 335 374 WD 4. |
Keyword | Complete proteome; Developmental protein; Reference proteome; Repeat; Ubl conjugation pathway; WD repeat; Wnt signaling pathway. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 412 AA |
Protein Sequence | MAAAAGEEEE EEEAARESAA RPAAGPALWR LPEELLLLIC SYLDMRALGR LAQVCRWLRR 60
FTSCDLLWRR IARASLNSGF TRLGTDLMTS VPVKERVKVS QNWRLGRCRE GILLKWRCSQ 120
MPWMQLEDDS LYISQANFIL AYQFRPDGAS LNRRPLGVFA GHDEDVCHFV LANSHIVSAG 180
GDGKIGIHKI HSTFTVKYSA HEQEVNCVDC KGGIIVSGSR DRTAKVWPLA SGRLGQCLHT 240
IQTEDRVWSI AISPLLSSFV TGTACCGHFS PLRIWDLNSG QLMTHLGSDF PPGAGVLDVM 300
YESPFTLLSC GYDTYVRYWD LRTSVRKCVM EWEEPHDSTL YCLQTDGNHL LATGSSYYGV 360
VRLWDRRQRA CLHAFPLTST PLSSPVYCLR LTTKHLYAAL SYNLHVLDFQ NP 412 |
Gene Ontology | GO:0000151; C:ubiquitin ligase complex; NAS:UniProtKB. GO:0051216; P:cartilage development; IEA:Compara. GO:0042733; P:embryonic digit morphogenesis; IEA:Compara. GO:0030326; P:embryonic limb morphogenesis; NAS:UniProtKB. GO:0002053; P:positive regulation of mesenchymal cell proliferation; IEA:Compara. GO:0006511; P:ubiquitin-dependent protein catabolic process; NAS:UniProtKB. GO:0016055; P:Wnt receptor signaling pathway; IEA:UniProtKB-KW. |
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