CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-016676
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 NHL repeat-containing protein 2 
Protein Synonyms/Alias
  
Gene Name
 Nhlrc2 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Mus musculus (Mouse) 
NCBI Taxa ID
 10090 
Lysine Modification
Position
Peptide
Type
References
572VSVLPVCKSDSAVVDubiquitination[1]
Reference
 [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023] 
Functional Description
  
Sequence Annotation
 DOMAIN 48 196 Thioredoxin.
 REPEAT 212 254 NHL 1.
 REPEAT 265 307 NHL 2.
 REPEAT 335 369 NHL 3.
 REPEAT 409 439 NHL 4.
 REPEAT 461 505 NHL 5.
 REPEAT 517 561 NHL 6.  
Keyword
 Complete proteome; Reference proteome; Repeat. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 725 AA 
Protein Sequence
MAAPGARGAS LSGLLPAQTS LEYALLDAVT QQEKDELVYQ YLQKVDGWEQ DLAVPEFPEG 60
LEWLNTEEPL SIYKDLCGKV VVLDFFTYCC INCIHVLPDL HALERRFSDK DGLLIVGVHS 120
AKFPNEKVLD NIKSAVLRYN ITHPVVNDAD ASLWQELEVS CWPTLVILGP RGNLLFSLIG 180
EGHRDKLFSY TSIALKYYKD RGQIRDGKIG IKLFKESLPP SPLLFPGKVA VDHATGRLVV 240
ADTGHHRILV IQKNGRIQSS IGGPNPGRKD GMFSESSFNS PQGVAIADNV IYVADTENHL 300
IRKIDLEAEK VTTVAGVGIQ GTDTEGGEEG DKQPISSPWD VALGTSGSEV QRNDILWIAM 360
AGTHQIWALL LDSGTLPKKS DLKKGTCIRF AGSGNEENRN NAYPHKAGFA QPSGLALASE 420
EPWSCLFVAD SESSTVRTVS LRDGAVKHLV GGERDPMNLF AFGDVDGAGI NAKLQHPLGV 480
AWDEERQVLY VADSYNHKIK VVDPKTKGCT TLAGTGDASD ASSSFAESAF NEPGGLCIGE 540
SGRLLYVADT NNHQIKVMDL EARTVSVLPV CKSDSAVVDG SFPREKQKTV PKVPKSAAHI 600
GLPPVTVHPG QALQLRLKLQ LPPGAKLTEG APSCWFLEAE GNEWLLQEQT PSGDIENISN 660
QPAISLQIPT HCLSLEAVVS VVVFLYYCSA DSSACMMKGV VFRQPLQITS TQPACAAPVE 720
LAYAF 725 
Gene Ontology
  
Interpro
 IPR011042; 6-blade_b-propeller_TolB-like.
 IPR000033; LDLR_classB_rpt.
 IPR001258; NHL_repeat.
 IPR012336; Thioredoxin-like_fold. 
Pfam
 PF01436; NHL 
SMART
 SM00135; LY 
PROSITE
 PS51125; NHL
 PS51352; THIOREDOXIN_2 
PRINTS