CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-038154
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
  
Protein Name
 Transformation/transcription domain-associated protein 
Protein Synonyms/Alias
  
Gene Name
 Trrap 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Mus musculus (Mouse) 
NCBI Taxa ID
 10090 
Lysine Modification
Position
Peptide
Type
References
897VAYRVLGKFGGSNRKubiquitination[1]
2361IEKSPDAKILRAVVKacetylation[2]
2542FAMVTHVKQEPREREacetylation[3]
3077PIVDCFQKIRQQVKCacetylation[4]
Reference
 [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023]
 [2] Label-free quantitative proteomics of the lysine acetylome in mitochondria identifies substrates of SIRT3 in metabolic pathways.
 Rardin MJ, Newman JC, Held JM, Cusack MP, Sorensen DJ, Li B, Schilling B, Mooney SD, Kahn CR, Verdin E, Gibson BW.
 Proc Natl Acad Sci U S A. 2013 Apr 16;110(16):6601-6. [PMID: 23576753]
 [3] Proteomic investigations of lysine acetylation identify diverse substrates of mitochondrial deacetylase sirt3.
 Sol EM, Wagner SA, Weinert BT, Kumar A, Kim HS, Deng CX, Choudhary C.
 PLoS One. 2012;7(12):e50545. [PMID: 23236377]
 [4] Quantitative acetylome analysis reveals the roles of SIRT1 in regulating diverse substrates and cellular pathways.
 Chen Y, Zhao W, Yang JS, Cheng Z, Luo H, Lu Z, Tan M, Gu W, Zhao Y.
 Mol Cell Proteomics. 2012 Oct;11(10):1048-62. [PMID: 22826441
Functional Description
  
Sequence Annotation
  
Keyword
 Complete proteome; Reference proteome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 3858 AA 
Protein Sequence
MAFVATQGAT VVDQTTLMKK YLQFVAALTD VNTPDETKLK MMQEVSENFE NVTSSPQYST 60
FLEHIIPRFL TFLQDGEVQF LQEKPAQQLR KLVLEILHRI PTNEHLRPHT KNVLSVMFRF 120
LETENEENVL ICLRIIIELH KQFRPPITQE IHHFLDFVKQ IYKELPKVVN RYFENPQGIP 180
ENTVPPPEMV GMITTVAVKV NPEREDSETR THSIIPRGSL SLKVLAELPI IVVLMYQLYK 240
LNIHNVVAEF VPLIMNTIAI QVSTQARQHK LYNKELYADF IAAQIKTLSF LAYIIRIYQE 300
LVTKYSQQMV KGMLQLLSNC PAETAHLRKE LLIAAKHILT TELRNQFIPC MDKLFDESIL 360
IGSGYTARET LRPLAYSTLA DLVHHVRQHL PLSDLSLAVQ LFAKNIDDES LPSSIQTMSC 420
KLLLNLVDCI RSKSEQESGN GRDVLMRMLE VFVLKFHTIA RYQLSAIFKK CKPQSELGAA 480
EAALPGVPTA PAAPGPAPSP APVPAPAPPP PPPPAPATPV TPAPVPPFEK QGEKDKEDKQ 540
TFQVTDCRSL VKTLVCGVKT ITWGITSCKA PGAQFIPNKQ LQPKETQIYI KLVKYAMQAL 600
DIYQVQIAGN GQTYIRVANC QTVRMKEEKE VLEHFAGVFT MMNPLTFKEI FQTTVPYMVE 660
RISKNYALQI VANSFLANPT TSALFATILV EYLLERLPEM GSNVELSNLY LKLFKLVFGS 720
VSLFAAENEQ MLKPHLHKIV NSSMELAQTA KEPYNYFLLL RALFRSIGGG SHDLLYQEFL 780
PLLPNLLQGL NMLQSGLHKQ HMKDLFVELC LTVPVRLSSL LPYLPMLMDP LVSALNGSQT 840
LVSQGLRTLE LCVDNLQPDF LYDHIQPVRA ELMQALWRTL RNPADSISHV AYRVLGKFGG 900
SNRKMLKESQ KLHYVVTEVQ GPSITVEFSD CKASLQLPME KAIETALDCL KSANTEPYYR 960
RQAWEVIRCF LVAMMSLEDN KHALYQLLAH PNFTEKTIPN VIISHRYKAQ DTPARKTFEQ 1020
ALTGAFMSAV IKDLRPSALP FVASLIRHYT MVAVAQQCGP FLLPCYQVGS QPSTAMFHSE 1080
ENGSKGMDPL VLIDAIAICM AYEEKELCKI GEVALAVIFD VASIILGSKE RACQLPLFSY 1140
IVERLCACCY EQAWYAKLGG VVSIKFLMER LPLTWVLQNQ QTFLKALLFV MMDLTGEVSN 1200
GAVAMAKTTL EQLLMRCATP LKDEERAEEI VLAQEKSFHH VTHDLVREVT SPNSTVRKQA 1260
MHSLQVLAQV TGKSVTVIME PHKEVLQDMV PPKKHLLRHQ PANAQIGLME GNTFCTTLQP 1320
RLFTMDLNVV EHKVFYTELL NLCEAEDSAL TKLPCYKSLP SLVPLRIAAL NALAACNYLP 1380
QSREKIIAAL FKALNSTNSE LQEAGEACMR KFLEGATIEV DQIHTHMRPL LMMLGDYRSL 1440
TLNVVNRLTS VTRLFPNSFN DKFCDQMMQH LRKWMEVVVI THKGGQRSDG NESLSECGRC 1500
SLSPFCQFEE MKICSAIINL FHLIPAAPQT LVKPLLEVVM KTERAMLIEA GSPFREPLIK 1560
FLTRHPSQTV ELFMMEATLN DPQWSRMFMS FLKHKDARPL RDVLAANPNR FITLLLPGGA 1620
QTAVRPGSPS TSNMRLDLQF QAIKIISIIV KNDDAWLASQ HSLVSQLRRV WVSETFQERH 1680
RKENMAATNW KEPKLLAFCL LNYCKRNYGD IELLFQLLRA FTGRFLCNMT FLKEYMEEEI 1740
PKNYSIAQKR ALFFRFVEFN DPNFGDELKA KVLQHILNPA FLYSFEKGEG EQLLGPPNPE 1800
GDNPESITSV FITKVLDPEK QADMLDSLRI YLLQYATLLV EHAPHHIHDN NKNRNSKLRR 1860
LMTFAWPCLL SKACVDPACK YSGHLLLAHI IAKFAIHKKI VLQVFHSLLK AHAMEARAIV 1920
RQAMAILTPA VPARMEDGHQ MLTHWTRKII VEEGHTVPQL VHILHLIVQH FKVYYPVRHH 1980
LVQHMVSAMQ RLGFTPSVTI EQRRLAVDLS EVVIKWELQR IKDQQPDSDM DPNSSGEGVN 2040
SVSIKRGLSV DSAQEVKRFR AATGAISAVF GRSQSLPGAD SLLAKPIDKQ HTDTVVNFLI 2100
RVACQVNDNT NTAGSPGEVL SRRCVNLLKT ALRPDMWCKS ELKLQWFDKL LMTVEQPNQV 2160
NYGNICTGLE VLNFLLTVLQ SPAILSSFKP LQRGIAACMT CGNTKVLRAV HSLLSRLMSI 2220
FPTEPSTSSV ASKYEELECL YAAVGKVIYE GLTNYEKATS ANPSQLFGTL MILKSACCNN 2280
PSYIDRLISV FMRSLQKMVR EHLNPQTASG STEATAAGTS ELVMLSLDLV KTRLAVMSME 2340
MRKNFIQTIL TSLIEKSPDA KILRAVVKIV EEWVKNNSPM AANQTPTLRE KSILLVKMMT 2400
YIEKRFPEDL ELNAQFLDLV NYVYRDEALS GSELTAKLEP AFLSGLRCAQ PLIRAKFFEV 2460
FDNSMKRRVY ERLLYVTCSQ NWEAMGSHFW IKQCIELLLA VCEKSTAIGT SCQGAMLPSI 2520
TNVINLADSH DRAAFAMVTH VKQEPREREN SESKEEDVEI DIELAPGDQT STPKTKELSE 2580
KDIGNQLHML TNRHDKFLDT LREVKTGALL SAFVQLCHIS TTLAEKTWVQ LFPRLWKILS 2640
DRQQHALAGE ISPFLCSGSH QVQRDCQPSA LNCFVEAMSQ CVPPIPMRPC VLKYLGKTHN 2700
LWFRSTLMLE HQAFEKGLSL PIKPKQTTEF YEQESITPPQ QEILDSLAEL YSLLQEEDMW 2760
AGLWQKRCKF SETATAIAYE QHGFFEQAQE SYEKAMDKAK KEHERSNASP AIFPEYQLWE 2820
DHWIRCSKEL NQWEALTEFG QSKGHINPYL VLECAWRVSN WTAMKEALVQ VEVSCPKEMA 2880
WKVNMYRGYL AICHPEEQQL SFIERLVEMA SSLAIREWRR LPHVVSHVHT PLLQAAQQII 2940
ELQEAAQINA GLQPTNLGRN NSLHDMKTVV KTWRNRLPIV SDDLSHWSSV FMWRQHHYQG 3000
KPTWSGMHSS SIVTAYENSS HHDPSSNNAM LGVHASASAI IQYGKIARKQ GLVNVALDIL 3060
SRIHTIPTVP IVDCFQKIRQ QVKCYLQLAG VMGKNECMQG LEVIESTNLK YFTKEMTAEF 3120
YALKGMFLAQ INKSEEANKA FSAAVQMHDV LVKAWAMWGD YLESIFVKER QLHLGVSAIT 3180
CYLHACRHQN ESKSRKYLAK VLWLLSFDDD KNTLADAVDK YCIGVPPIQW LAWIPQLLTC 3240
LVGSEGKLLL NLISQVGRVY PQAVYFPIRT LYLTLKIEQR ERYKSDPGPI RATAPMWRCS 3300
RIMHMQRELH PTLLSSLEGI VDQMVWFREN WHEEVLRQLQ QGLAKCYSVA FEKSGAVSDA 3360
KITPHTLNFV KKLVSTFGVG LENVSNVSTM FSSAASESLA RRAQATAQDP VFQKLKGQFT 3420
TDFDFSVPGS MKLHNLISKL KKWIKILEAK TKQLPKFFLI EEKCRFLSNF SAQTAEVEIP 3480
GEFLMPKPTH YYIKIARFMP RVEIVQKHNT AARRLHIRGH NGKIYPYLVM NDACLTESRR 3540
EERVLQLLRL LNPCLEKRKE TTKRHLFFTV PRVVAVSPQM RLVEDNPSSL SLVEIYKQRC 3600
AKKGIEHDNP ISRYYDRLAT VQARGTQASH QVLRDILKEV QSNMVPRSML KEWALHTFPN 3660
ATDYWTFRKM FTIQLALIGF AEFVLHLNRL NPEMLQIAQD TGKLNVAYFR FDINDATGDL 3720
DANRPVPFRL TPNISEFLTT IGVSGPLTAS MIAVARCFAQ PNFKVDGVLK TVLRDEIIAW 3780
HKKTQEDTSS PLSAAGQPEN MDSQQLVSLV QKAVTAIMTR LHNLAQFDGG ESKVNTLVAA 3840
ANSLDNLCRM DPAWHPWL 3858 
Gene Ontology
 GO:0000123; C:histone acetyltransferase complex; TAS:MGI.
 GO:0005667; C:transcription factor complex; IDA:MGI.
 GO:0016773; F:phosphotransferase activity, alcohol group as acceptor; IEA:InterPro.
 GO:0003713; F:transcription coactivator activity; IDA:MGI.
 GO:0007093; P:mitotic cell cycle checkpoint; IMP:MGI.
 GO:0006355; P:regulation of transcription, DNA-dependent; IDA:MGI. 
Interpro
 IPR011989; ARM-like.
 IPR016024; ARM-type_fold.
 IPR003152; FATC.
 IPR011009; Kinase-like_dom.
 IPR000403; PI3/4_kinase_cat_dom.
 IPR003151; PIK-rel_kinase_FAT.
 IPR014009; PIK_FAT.
 IPR011990; TPR-like_helical. 
Pfam
 PF02259; FAT
 PF00454; PI3_PI4_kinase 
SMART
 SM00146; PI3Kc 
PROSITE
 PS51189; FAT
 PS51190; FATC
 PS50290; PI3_4_KINASE_3 
PRINTS