CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-034869
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
  
Protein Name
 Protein Brd4 
Protein Synonyms/Alias
  
Gene Name
 Brd4 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Rattus norvegicus (Rat) 
NCBI Taxa ID
 10116 
Lysine Modification
Position
Peptide
Type
References
595EPAPTKTKPPPTYESacetylation[1]
695DVIAGSSKMKGFSSSacetylation[1]
1193LPQRPEMKPVDVGRPacetylation[1]
1232KTPVAPKKDLKIKNMacetylation[1]
1235VAPKKDLKIKNMGSWacetylation[1]
1237PKKDLKIKNMGSWASacetylation[1]
Reference
 [1] Proteomic analysis of lysine acetylation sites in rat tissues reveals organ specificity and subcellular patterns.
 Lundby A, Lage K, Weinert BT, Bekker-Jensen DB, Secher A, Skovgaard T, Kelstrup CD, Dmytriyev A, Choudhary C, Lundby C, Olsen JV.
 Cell Rep. 2012 Aug 30;2(2):419-31. [PMID: 22902405] 
Functional Description
  
Sequence Annotation
  
Keyword
 Bromodomain; Complete proteome; Reference proteome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 1403 AA 
Protein Sequence
MSTESGPGTR LRNLPVMGDG LETSQMSTTQ AQAQPQSANA ASTNPPPPET SNPNKPKRQT 60
NQLQYLLRVV LKTLWKHQFA WPFQQPVDAV KLNLPDYYKI IKTPMDMGTI KKRLENNYYW 120
NAQECIQDFN TMFTNCYIYN KPGDDIVLMA EALEKLFLQK INELPTEETE IMIVQAKGRG 180
RGRKETGTAK PGVSTVPNTT QASTSPQTQM PQQNPPPPVQ ATTHPFPAVT PDLIAQPPVM 240
TMVPPQPLQT PSPVPPQPPP PPAPVPQPVQ SHPPIIATTP QPVKTKKGVK RKADTTTPTT 300
IDPIHEPPSL APEPKTAKLG PRRESSRPVK PPKKDVPDSQ QHPGPEKSSK ISEQLKCCSG 360
ILKEMFAKKH AAYAWPFYKP VDVEALGLHD YCDIIKHPMD MSTIKSKLES REYRDAQEFG 420
ADVRLMFSNC YKYNPPDHEV VAMARKLQDV FEMRFAKMPD EPEEPVVTVS SPAVPPPTKV 480
VAPPSSSDSS SDSSSDSDSS TDDSEEERAQ RLAELQEQLK AVHEQLAALS QPQQNKPKKK 540
EKDKKEKKKE KHKKKEEMEE NKKSKAKELP PKKTKKNNSS NSNVSKKEPA PTKTKPPPTY 600
ESEEEDKCKP MSYEEKRQLS LDINKLPGEK LGRVVHIIQS REPSLKNSNP DEIEIDFETL 660
KPSTLRELER YVTSCLRKKR KPQAEKVDVI AGSSKMKGFS SSESESTSES SSSDSEDSET 720
EMAPKSKKKG HTGRDQKKHH HHHHPQMQPA PAPVPQQPPP PPQQPPPPPP PQQQQQQQQQ 780
QPPPPPPPPS MPQQTAPAMK SSPPPFITAQ VPVLEPQLPG SVFDPIGHFT QPILHLPQPE 840
LPPHLPQPPE HSTPPHLNQH AVVSPPALHN ALPQQPSRPS NRAAALPPKP ARPPAVSPAL 900
AQPPLLPQPP MAQPPQVLLE DEEPPAPPLT SMQMQLYLQQ LQKVQPPTPL LPSVKVQSQP 960
PPPLPPPPHP SVQQQQLQQQ PPPPPPPQPQ PPPQQQHQPP PRPVHLPSMP FSAHIQQPPP 1020
PTGQQPTHPP PGQQPPPPQP AKPQQVIQHH PSPRHHKSDP YSAGHLREAP SPLMIHSPQM 1080
PQFQSLTHQS PPQQNVQPKK QVKGRAEPQP PGPVMGRGQG CPPASPAAVP MLSQELRPPS 1140
VVQPQPLVVV KEEKIHSPII RSEPFSTSLR PEPPKHPENM KAPVHLPQRP EMKPVDVGRP 1200
VIRPPEQSAP PPGAPDKDKQ KQEPKTPVAP KKDLKIKNMG SWASLVQKHP TTPSSTAKSS 1260
SDSFEHFRRA AREKEEREKA LKAQAEHAEK EKERLRQERM RSREDEDALE QARRAHEEAR 1320
RRQEQQQQQQ RQEQQQQQQQ QAAAVAAASA PQAQSSQPQS MLDQQRELAR KREQERRRRE 1380
AMAATIDMNF QSDLLSIFEE NLF 1403 
Gene Ontology
 GO:0000794; C:condensed nuclear chromosome; IEA:Compara.
 GO:0005737; C:cytoplasm; IEA:Compara.
 GO:0000790; C:nuclear chromatin; IEA:Compara.
 GO:0003677; F:DNA binding; IEA:Compara.
 GO:0007059; P:chromosome segregation; IEA:Compara.
 GO:0044154; P:histone H3-K14 acetylation; IEA:Compara.
 GO:0043983; P:histone H4-K12 acetylation; IEA:Compara.
 GO:0001833; P:inner cell mass cell proliferation; IEA:Compara.
 GO:0043388; P:positive regulation of DNA binding; IEA:Compara.
 GO:0010971; P:positive regulation of G2/M transition of mitotic cell cycle; IEA:Compara.
 GO:0032968; P:positive regulation of transcription elongation from RNA polymerase II promoter; IEA:Compara.
 GO:0006468; P:protein phosphorylation; IEA:Compara.
 GO:0000114; P:regulation of transcription involved in G1 phase of mitotic cell cycle; IEA:Compara. 
Interpro
 IPR001487; Bromodomain.
 IPR018359; Bromodomain_CS.
 IPR027353; NET_dom. 
Pfam
 PF00439; Bromodomain 
SMART
 SM00297; BROMO 
PROSITE
 PS00633; BROMODOMAIN_1
 PS50014; BROMODOMAIN_2
 PS51525; NET 
PRINTS
 PR00503; BROMODOMAIN.