UniProt Accession

 MPH6_HUMAN; Q99547; B2RAF0 

Genbank Protein ID

 X98263; AK314163; AC138304; BC005242; BC011020; BC031017 

Genbank Nucleotide ID

 CAA66916.1; BAG36847.1; AAH05242.1; AAH11020.1; AAH31017.1 

Protein Name

 M-phase phosphoprotein 6 

Protein Synonyms/Alias

  

Gene Name

 MPHOSPH6 

Gene Synonyms/Alias

 MPP6 

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
11	ERKTRLSKNLLRMKF	ubiquitination	[1]
17	SKNLLRMKFMQRGLD	ubiquitination	[1]
54	DLPELKEKESFIIEE	ubiquitination	[1]
86	GFNPEVEKLMLQMNA	ubiquitination	[1, 2]
96	LQMNAKHKAEEVEDE	ubiquitination	[1]
127	TLVGTIGKKFARKRD	ubiquitination	[2]
128	LVGTIGKKFARKRDH	ubiquitination	[1]
132	IGKKFARKRDHANYE	ubiquitination	[1]
150	NGDITPIKAKKMFLK	ubiquitination	[2]
153	ITPIKAKKMFLKPQD	ubiquitination	[1]
157	KAKKMFLKPQD****	ubiquitination	[1]

Reference

 [1] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961]
 [2] Systematic and quantitative assessment of the ubiquitin-modified proteome.
 Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
 Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983] 

Functional Description

 RNA-binding protein that associates with the RNA exosome complex. Involved in the 3'processing of the 7S pre-RNA to the mature 5.8S rRNA and may play a role in recruiting the RNA exosome complex to pre-rRNA; this function may include C1D. 

Sequence Annotation

 MOTIF 116 133 Nuclear localization signal (Potential).
 MOD_RES 110 110 Phosphoserine.
 MOD_RES 147 147 Phosphothreonine.  

Keyword

 Complete proteome; Cytoplasm; Nucleus; Phosphoprotein; Polymorphism; Reference proteome; RNA-binding; rRNA processing. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 160 AA 

Protein Sequence

Gene Ontology

 GO:0005737; C:cytoplasm; IDA:HPA.
 GO:0000178; C:exosome (RNase complex); IDA:UniProtKB.
 GO:0005730; C:nucleolus; IDA:HPA.
 GO:0003723; F:RNA binding; IEA:UniProtKB-KW.
 GO:0000087; P:M phase of mitotic cell cycle; TAS:ProtInc.
 GO:0000460; P:maturation of 5.8S rRNA; IMP:UniProtKB. 

Interpro

 IPR019324; MPP6. 

Pfam

 PF10175; MPP6 

SMART

  

PROSITE

  

PRINTS