UniProt Accession

 MOT2_HUMAN; O60669; Q8NEM3; Q9UPB3 

Genbank Protein ID

 AF049608; AF058056; AK313345; AC079905; CH471054; BC030693 

Genbank Nucleotide ID

 AAC70919.1; AAC13721.1; BAG36148.1; EAW97096.1; AAH30693.1 

Protein Name

 Monocarboxylate transporter 2 

Protein Synonyms/Alias

 MCT 2; Solute carrier family 16 member 7 

Gene Name

 SLC16A7 

Gene Synonyms/Alias

 MCT2 

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
213	KSKNKTGKTEDDSSP	ubiquitination	[1]
221	TEDDSSPKKIKTKKS	ubiquitination	[1]
453	RESEPLSKSKHSEDV	ubiquitination	[1]
455	SEPLSKSKHSEDVNV	ubiquitination	[1]
463	HSEDVNVKVSNAQSV	ubiquitination	[1, 2, 3]

Reference

 [1] Landscape of the PARKIN-dependent ubiquitylome in response to mitochondrial depolarization.
 Sarraf SA, Raman M, Guarani-Pereira V, Sowa ME, Huttlin EL, Gygi SP, Harper JW.
 Nature. 2013 Apr 18;496(7445):372-6. [PMID: 23503661]
 [2] Systematic and quantitative assessment of the ubiquitin-modified proteome.
 Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
 Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983]
 [3] Ubiquitin ligase substrate identification through quantitative proteomics at both the protein and peptide levels.
 Lee KA, Hammerle LP, Andrews PS, Stokes MP, Mustelin T, Silva JC, Black RA, Doedens JR.
 J Biol Chem. 2011 Dec 2;286(48):41530-8. [PMID: 21987572] 

Functional Description

 Proton-linked monocarboxylate transporter. Catalyzes the rapid transport across the plasma membrane of many monocarboxylates such as lactate, pyruvate, branched-chain oxo acids derived from leucine, valine and isoleucine, and the ketone bodies acetoacetate, beta-hydroxybutyrate and acetate. MCT2 is a high affinity pyruvate transporter. 

Sequence Annotation

  

Keyword

 Cell membrane; Complete proteome; Membrane; Polymorphism; Reference proteome; Symport; Transmembrane; Transmembrane helix; Transport. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 478 AA 

Protein Sequence

Gene Ontology

 GO:0005887; C:integral to plasma membrane; TAS:ProtInc.
 GO:0005477; F:pyruvate secondary active transmembrane transporter activity; TAS:ProtInc.
 GO:0015355; F:secondary active monocarboxylate transmembrane transporter activity; IEA:InterPro.
 GO:0015293; F:symporter activity; IEA:UniProtKB-KW. 

Interpro

 IPR027178; MCT2.
 IPR011701; MFS.
 IPR020846; MFS_dom.
 IPR016196; MFS_dom_general_subst_transpt.
 IPR004743; Monocarb_transpt. 

Pfam

 PF07690; MFS_1 

SMART

  

PROSITE

 PS50850; MFS 

PRINTS