CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-020774
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 B-cell CLL/lymphoma 9 protein 
Protein Synonyms/Alias
 B-cell lymphoma 9 protein; Bcl-9 
Gene Name
 Bcl9 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Mus musculus (Mouse) 
NCBI Taxa ID
 10090 
Lysine Modification
Position
Peptide
Type
References
843VQRGLGRKPLDISVAacetylation[1, 2]
Reference
 [1] Quantitative acetylome analysis reveals the roles of SIRT1 in regulating diverse substrates and cellular pathways.
 Chen Y, Zhao W, Yang JS, Cheng Z, Luo H, Lu Z, Tan M, Gu W, Zhao Y.
 Mol Cell Proteomics. 2012 Oct;11(10):1048-62. [PMID: 22826441]
 [2] SIRT5-Mediated Lysine Desuccinylation Impacts Diverse Metabolic Pathways.
 Park J, Chen Y, Tishkoff DX, Peng C, Tan M, Dai L, Xie Z, Zhang Y, Zwaans BM, Skinner ME, Lombard DB, Zhao Y.
 Mol Cell. 2013 Jun 27;50(6):919-30. [PMID: 23806337] 
Functional Description
 Promotes beta-catenin's transcriptional activity. Involved in signal transduction through the Wnt pathway (By similarity). 
Sequence Annotation
 REGION 347 377 CTNNB1-binding (By similarity).
 MOD_RES 172 172 Phosphothreonine (By similarity).
 MOD_RES 315 315 Phosphothreonine (By similarity).
 MOD_RES 318 318 Phosphoserine (By similarity).
 MOD_RES 352 352 Phosphoserine.
 MOD_RES 906 906 Phosphoserine (By similarity).
 MOD_RES 916 916 Phosphoserine (By similarity).  
Keyword
 Complete proteome; Nucleus; Phosphoprotein; Reference proteome; Wnt signaling pathway. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 1425 AA 
Protein Sequence
MHPSNPKVRS SPSGNTQSSP KSKQEVMVRP PTVMSPSGNP QLDSKFSNQG KPGGSASQSQ 60
PSPCDSKSGG HTPKALPGPG GSMGLKNGAG NGAKGKGKRE RSISADSFDQ RDPGTPNDDS 120
DIKECNSADH IKSQESQHTP HSMTPSTATA PRSSTPSHGQ TPAPEPISAQ KTPAKVVYVF 180
STEMANKAAE AVLKGQVETI VSFHIQNISN SKSERSTAPL NTQIPTLRND PKPLPQQPPA 240
PANQDQNSSQ NARLQPTPPI QAPAPKPTAA PRPLDRESPG VENKLIPPVG SPGSSTPLPP 300
DGTGPNSTPN NRAVTPVSQG SNSSSADPKA PPPPPVSGGE PPTLGENPDG LSQEQLEHRE 360
RSLQTLRDIQ RMLFPDEKEF TAGQTGGPQQ NTGVLDGPQK KPDGPIQAMM SQSQSLGKGP 420
GPRTDVGAPF GPQGHRDVPF SPDEMVPPNM SSQSGPIGPD HLDHMTPEQI AWLKLQQEFY 480
EEKRRKQEQV VVQQCSLQDM MVHQHGPRGV VRGPPPPYQM APGEGWAPGA EPFPDGINIS 540
HSLPPRGMAP HPNMPGSQMR LPGFAGMINS EMEGPNVPNP ASRPGLSGVS WPDDVPKIPD 600
GRNFPPGQGV FSGPGRGERF PNPQGLSEEM FQQQLAEKQL ALPPGMSMEG IRPGMEMNRM 660
IPGSQRHMEP GSNPIFPRIP VEGPLSPSRG DFPKGMPPQI GPGRELEFGM VPGGMKGEVN 720
LNVNMGSSSQ MIPQKMREAG AGPEEMMKLR PGSSEMLPAQ QKMVPLPFGE HPQQEYGVGP 780
RPFLPMSQGP GSNSGLRNLR EPIGPDQRTN SRLSHMPPLP LNPSSNPTSL STAPPVQRGL 840
GRKPLDISVA GSQVHSPGIN PLKSPTMHQV QSPMLGSPSG NLKSPQTPSQ LAGMLAGPAA 900
AASIKSPPVL GSAAASPVHL KSPSLPAPSP GWTSSPKPPL QSPGIPPNHK APLTMASPAM 960
LGSVESGGPP PPTASQPASV NIPGSLPSST PYPMPPEPTL SQNPLSIMMS RMSKFAMPSS 1020
TPLYHDAIKT VASSDDDSPP ARSPNLPSMN SMPGMGINTQ NPRISGPNPV VPMPTLSPMG 1080
MTQPLSHSNQ MPSPNAMGPS IPPHGVPMGP GLMSHNPIMG HGSQEPPMVP QGRMGFPQGF 1140
PPVQSPPQQV PFPHNGPTGG QGNFPGGIGF PGEGPLGRPS NLPQSSADPA LCKPGGPGAP 1200
DSFTVLGNSM PSVFTDPDLQ EVIRPGATGI PEFDLSRIIP SEKPSQTLQY FPRGEVPGRK 1260
QPQGPGPGFS HMQGMMSDQA PRMGLALPGM GGPGPVGTPD IPLGTSPSMP GHNPMRPPAF 1320
LQQGMMGPHH RMMSPAQSTV PGPATLMTNP AAAVGMIPGK DRGPAGLYTH PGPVGSPGMM 1380
MSMQGMMGPQ QNIMIPPQMR PRGMAADVGM GGFSQGPGNP GNMMF 1425 
Gene Ontology
 GO:0005794; C:Golgi apparatus; IDA:MGI.
 GO:0005634; C:nucleus; IDA:MGI.
 GO:0060070; P:canonical Wnt receptor signaling pathway; IGI:MGI.
 GO:0014908; P:myotube differentiation involved in skeletal muscle regeneration; IGI:MGI.
 GO:0045944; P:positive regulation of transcription from RNA polymerase II promoter; IGI:MGI.
 GO:0035019; P:somatic stem cell maintenance; IGI:MGI. 
Interpro
 IPR015668; Bcl-9.
 IPR024670; BCL9_beta-catenin-bd_dom. 
Pfam
 PF11502; BCL9 
SMART
  
PROSITE
  
PRINTS